JP2005509416A5 - - Google Patents

Info

Publication number

JP2005509416A5

JP2005509416A5 JP2003541440A JP2003541440A JP2005509416A5 JP 2005509416 A5 JP2005509416 A5 JP 2005509416A5 JP 2003541440 A JP2003541440 A JP 2003541440A JP 2003541440 A JP2003541440 A JP 2003541440A JP 2005509416 A5 JP2005509416 A5 JP 2005509416A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

pain

nucleic acid

amino acid

Prior art date

2002-11-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 102000004196 processed proteins & peptides Human genes 0.000 claims 41
• 108090000765 processed proteins & peptides Proteins 0.000 claims 41
• 229920001184 polypeptide Polymers 0.000 claims 40
• 150000001875 compounds Chemical class 0.000 claims 35
• 102000039446 nucleic acids Human genes 0.000 claims 23
• 108020004707 nucleic acids Proteins 0.000 claims 23
• 150000007523 nucleic acids Chemical class 0.000 claims 23
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 239000002773 nucleotide Substances 0.000 claims 22
• 125000003729 nucleotide group Chemical group 0.000 claims 22
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
• 208000027520 Somatoform disease Diseases 0.000 claims 13
• 238000000034 method Methods 0.000 claims 13
• 208000027753 pain disease Diseases 0.000 claims 13
• 208000002193 Pain Diseases 0.000 claims 9
• 230000007246 mechanism Effects 0.000 claims 6
• 230000008050 pain signaling Effects 0.000 claims 5
• 230000000694 effects Effects 0.000 claims 4
• 206010058019 Cancer Pain Diseases 0.000 claims 3
• 208000001387 Causalgia Diseases 0.000 claims 3
• 208000000094 Chronic Pain Diseases 0.000 claims 3
• 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 3
• 208000001640 Fibromyalgia Diseases 0.000 claims 3
• 206010019233 Headaches Diseases 0.000 claims 3
• 206010065390 Inflammatory pain Diseases 0.000 claims 3
• 208000019695 Migraine disease Diseases 0.000 claims 3
• 208000001294 Nociceptive Pain Diseases 0.000 claims 3
• 208000014439 complex regional pain syndrome type 2 Diseases 0.000 claims 3
• 231100000869 headache Toxicity 0.000 claims 3
• 206010027599 migraine Diseases 0.000 claims 3
• 208000004296 neuralgia Diseases 0.000 claims 3
• 208000021722 neuropathic pain Diseases 0.000 claims 3
• 230000003321 amplification Effects 0.000 claims 2
• 238000010171 animal model Methods 0.000 claims 2
• 238000003199 nucleic acid amplification method Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000019491 signal transduction Effects 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1