JP2005508633A5 - - Google Patents

Info

Publication number

JP2005508633A5

JP2005508633A5 JP2003539599A JP2003539599A JP2005508633A5 JP 2005508633 A5 JP2005508633 A5 JP 2005508633A5 JP 2003539599 A JP2003539599 A JP 2003539599A JP 2003539599 A JP2003539599 A JP 2003539599A JP 2005508633 A5 JP2005508633 A5 JP 2005508633A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

nucleic acid

amino acid

nucleotide sequence

Prior art date

2002-10-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 102000004196 processed proteins & peptides Human genes 0.000 claims 51
• 108090000765 processed proteins & peptides Proteins 0.000 claims 51
• 229920001184 polypeptide Polymers 0.000 claims 50
• 150000001875 compounds Chemical class 0.000 claims 31
• 102000039446 nucleic acids Human genes 0.000 claims 23
• 108020004707 nucleic acids Proteins 0.000 claims 23
• 150000007523 nucleic acids Chemical class 0.000 claims 23
• 125000003275 alpha amino acid group Chemical group 0.000 claims 22
• 239000002773 nucleotide Substances 0.000 claims 22
• 125000003729 nucleotide group Chemical group 0.000 claims 22
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
• 230000000694 effects Effects 0.000 claims 16
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
• 238000000034 method Methods 0.000 claims 14
• 102000012086 alpha-L-Fucosidase Human genes 0.000 claims 12
• 108010061314 alpha-L-Fucosidase Proteins 0.000 claims 12
• 230000033115 angiogenesis Effects 0.000 claims 12
• 210000004027 cell Anatomy 0.000 claims 11
• 230000002491 angiogenic effect Effects 0.000 claims 8
• 230000002062 proliferating effect Effects 0.000 claims 7
• 208000035269 cancer or benign tumor Diseases 0.000 claims 6
• 230000004663 cell proliferation Effects 0.000 claims 6
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 3
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
• 206010033128 Ovarian cancer Diseases 0.000 claims 3
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
• 208000029742 colonic neoplasm Diseases 0.000 claims 3
• 201000011066 hemangioma Diseases 0.000 claims 3
• 201000005202 lung cancer Diseases 0.000 claims 3
• 208000020816 lung neoplasm Diseases 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000003321 amplification Effects 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 210000002889 endothelial cell Anatomy 0.000 claims 1
• 210000002919 epithelial cell Anatomy 0.000 claims 1
• 230000001605 fetal effect Effects 0.000 claims 1
• 238000003199 nucleic acid amplification method Methods 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 210000002536 stromal cell Anatomy 0.000 claims 1