JP2005508885A - Ｄｎａメチル化の阻害剤 - Google Patents

Ｄｎａメチル化の阻害剤 Download PDF

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Publication number
JP2005508885A
JP2005508885A JP2003517229A JP2003517229A JP2005508885A JP 2005508885 A JP2005508885 A JP 2005508885A JP 2003517229 A JP2003517229 A JP 2003517229A JP 2003517229 A JP2003517229 A JP 2003517229A JP 2005508885 A JP2005508885 A JP 2005508885A
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JP
Japan
Prior art keywords
cell
zebralin
derivative
methylation
dna
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Application number
JP2003517229A
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English (en)
Japanese (ja)
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JP2005508885A5 (https=
Inventor
エリック ユー． セルカー
シンディ ビー． マットセン
シェルダン ビー． グリアー
ピーター エイ． ジョンズ
ジョナサン チェン
ビクター イー． マルケツ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Government of the United States of America
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University of Miami
Government of the United States of America
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Application filed by University of Miami, Government of the United States of America filed Critical University of Miami
Publication of JP2005508885A publication Critical patent/JP2005508885A/ja
Publication of JP2005508885A5 publication Critical patent/JP2005508885A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003517229A 2001-07-31 2002-07-30 Ｄｎａメチル化の阻害剤 Withdrawn JP2005508885A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30924201P 2001-07-31 2001-07-31
US31143501P 2001-08-10 2001-08-10
PCT/US2002/024223 WO2003012051A2 (en) 2001-07-31 2002-07-30 Inhibitor of dna methylation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010144618A Division JP5416660B2 (ja) 2001-07-31 2010-06-25 Ｄｎａメチル化の阻害剤

Publications (2)

Publication Number Publication Date
JP2005508885A true JP2005508885A (ja) 2005-04-07
JP2005508885A5 JP2005508885A5 (https=) 2006-01-05

Family

ID=26976683

Family Applications (2)

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JP2003517229A Withdrawn JP2005508885A (ja) 2001-07-31 2002-07-30 Ｄｎａメチル化の阻害剤
JP2010144618A Expired - Fee Related JP5416660B2 (ja) 2001-07-31 2010-06-25 Ｄｎａメチル化の阻害剤

Family Applications After (1)

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JP2010144618A Expired - Fee Related JP5416660B2 (ja) 2001-07-31 2010-06-25 Ｄｎａメチル化の阻害剤

Country Status (6)

Country Link
US (1) US8207142B2 (https=)
EP (1) EP1418949B1 (https=)
JP (2) JP2005508885A (https=)
AU (1) AU2002322805B2 (https=)
CA (1) CA2454147C (https=)
WO (1) WO2003012051A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010248223A (ja) * 2001-07-31 2010-11-04 State Of Oregon Acting By & Through The Oregon State Board Of Higher Education On Behalf Of The Univ Of Oregon Ｄｎａメチル化の阻害剤
JP2016540829A (ja) * 2013-11-14 2016-12-28 カイノス・メディスン・インコーポレイテッドＫａｉｎｏｓ Ｍｅｄｉｃｉｎｅ， Ｉｎｃ． がん治療のための短鎖脂肪酸およびゼブラリンまたは１’−シアノ−シタラビンを含む相互プロドラッグ

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309302B2 (en) * 2005-07-15 2012-11-13 Abbott Laboratories Reagents and methods for processing biological samples
GB0607063D0 (en) 2006-04-07 2006-05-17 Cellcentric Ltd Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
JP2009278867A (ja) * 2006-09-05 2009-12-03 Olympus Corp Ｄｎａメチル化阻害作用の判定方法
US20110300142A1 (en) * 2007-05-25 2011-12-08 Salford Leif G Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
US20140031250A1 (en) 2010-10-07 2014-01-30 David Tsai Ting Biomarkers of Cancer
US20150038548A1 (en) * 2012-07-09 2015-02-05 Metheor Therapeutics Corporation Oligonucleotide inhibitors of dna methyltransferases and their use in treating diseases
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
CN108779437A (zh) 2016-01-08 2018-11-09 麻省理工学院 分化的肠内分泌细胞和胰岛素产生细胞的制备
PL241125B1 (pl) * 2017-11-30 2022-08-08 Gdanski Univ Medyczny Kompozycja farmaceutyczna do zastosowania jako środek do pobudzania regeneracji lub gojenia ran
JP2021512956A (ja) 2018-02-06 2021-05-20 ザ ジェネラル ホスピタル コーポレイション 腫瘍免疫応答のバイオマーカーとしてのリピートｒｎａ

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US4894364A (en) * 1983-10-26 1990-01-16 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US5470974A (en) * 1985-03-15 1995-11-28 Neu-Gene Development Group Uncharged polynucleotide-binding polymers
US5607925A (en) * 1988-11-15 1997-03-04 Merrell Pharmaceuticals Inc. Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
US5503975A (en) * 1989-03-01 1996-04-02 City Of Hope Mechanism based inhibitors of DNA methyltransferase
EP0586523A4 (en) * 1991-05-15 1995-11-29 Univ Yale Determination of prodrugs metabolizable by the liver and therapeutic use thereof
GB9311252D0 (en) 1993-06-01 1993-07-21 Hafslund Nycomed As Cell growth regualtors
AU1061395A (en) * 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
CA2153125A1 (en) * 1994-08-31 1996-03-01 Frank Paul Abuto Liquid-absorbing article
US5872104A (en) * 1994-12-27 1999-02-16 Oridigm Corporation Combinations and methods for reducing antimicrobial resistance
US6020139A (en) * 1995-04-25 2000-02-01 Oridigm Corporation S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US5871917A (en) * 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6011200A (en) * 1997-07-30 2000-01-04 Yale University Methods for altering the rate of plant development and plants obtained therefrom
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
AU5128999A (en) * 1998-07-24 2000-02-14 Yeda Research And Development Co. Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
ATE339960T1 (de) 1999-03-01 2006-10-15 Halogenetics Inc Verwendung von zusammensetzungen enthaltend cldc als strahlungssensibilisatoren in der behandlung von neoplastischen erkrankungen
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
CA2454147C (en) * 2001-07-31 2013-05-21 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Inhibitor of dna methylation
EP1718150A1 (en) 2004-02-25 2006-11-08 The Government of the United States of America, represented by the Secretary, Department of Health and Human Services Methylation inhibitor compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010248223A (ja) * 2001-07-31 2010-11-04 State Of Oregon Acting By & Through The Oregon State Board Of Higher Education On Behalf Of The Univ Of Oregon Ｄｎａメチル化の阻害剤
JP2016540829A (ja) * 2013-11-14 2016-12-28 カイノス・メディスン・インコーポレイテッドＫａｉｎｏｓ Ｍｅｄｉｃｉｎｅ， Ｉｎｃ． がん治療のための短鎖脂肪酸およびゼブラリンまたは１’−シアノ−シタラビンを含む相互プロドラッグ
US10500224B2 (en) 2013-11-14 2019-12-10 Kainos Medicine, Inc. Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment

Also Published As

Publication number Publication date
JP2010248223A (ja) 2010-11-04
JP5416660B2 (ja) 2014-02-12
WO2003012051A2 (en) 2003-02-13
WO2003012051A3 (en) 2003-10-30
EP1418949A2 (en) 2004-05-19
AU2002322805A2 (en) 2003-02-17
EP1418949A4 (en) 2009-03-04
CA2454147A1 (en) 2003-02-13
US8207142B2 (en) 2012-06-26
WO2003012051A8 (en) 2003-08-14
US20050119201A1 (en) 2005-06-02
AU2002322805B2 (en) 2007-11-08
CA2454147C (en) 2013-05-21
EP1418949B1 (en) 2013-06-19

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