JP2005508632A5 - - Google Patents

Info

Publication number

JP2005508632A5

JP2005508632A5 JP2003530811A JP2003530811A JP2005508632A5 JP 2005508632 A5 JP2005508632 A5 JP 2005508632A5 JP 2003530811 A JP2003530811 A JP 2003530811A JP 2003530811 A JP2003530811 A JP 2003530811A JP 2005508632 A5 JP2005508632 A5 JP 2005508632A5

Authority

JP

Japan

Prior art keywords

mch

binding protein

antagonist binding

seq

antagonist

Prior art date

2002-09-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000005557 antagonist Substances 0.000 claims 21
• 102000014914 Carrier Proteins Human genes 0.000 claims 20
• 108091008324 binding proteins Proteins 0.000 claims 20
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 8
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 3
• 239000013604 expression vector Substances 0.000 claims 3
• XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 2
• 239000000556 agonist Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108091008039 hormone receptors Proteins 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1