WO2000050563A3 - G protein-coupled receptor resembling galanin receptors - Google Patents

G protein-coupled receptor resembling galanin receptors Download PDF

Info

Publication number
WO2000050563A3
WO2000050563A3 PCT/US2000/004416 US0004416W WO0050563A3 WO 2000050563 A3 WO2000050563 A3 WO 2000050563A3 US 0004416 W US0004416 W US 0004416W WO 0050563 A3 WO0050563 A3 WO 0050563A3
Authority
WO
WIPO (PCT)
Prior art keywords
coupled receptor
protein
resembling
galanin receptors
gpr54
Prior art date
Application number
PCT/US2000/004416
Other languages
French (fr)
Other versions
WO2000050563A9 (en
WO2000050563A2 (en
Inventor
Andrew D Howard
Gary P O'neill
Brian O'dowd
Susan George
Original Assignee
Merck & Co Inc
Merck Frosst Canada Inc
Univ Toronto
Andrew D Howard
Neill Gary P O
Dowd Brian O
Susan George
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Frosst Canada Inc, Univ Toronto, Andrew D Howard, Neill Gary P O, Dowd Brian O, Susan George filed Critical Merck & Co Inc
Priority to JP2000601127A priority Critical patent/JP2002536989A/en
Priority to CA002364988A priority patent/CA2364988A1/en
Priority to EP00921344A priority patent/EP1157097A4/en
Publication of WO2000050563A2 publication Critical patent/WO2000050563A2/en
Publication of WO2000050563A3 publication Critical patent/WO2000050563A3/en
Publication of WO2000050563A9 publication Critical patent/WO2000050563A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Abstract

Human and rat DNAs encoding a novel G-protein coupled receptor, GPR54, as well as proteins encoded by the DNAs, are provided. Methods of identifying agonists and antagonists of GPR54 are also provided.
PCT/US2000/004416 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors WO2000050563A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000601127A JP2002536989A (en) 1999-02-24 2000-02-22 G protein-coupled receptor similar to galanin receptor
CA002364988A CA2364988A1 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors
EP00921344A EP1157097A4 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12165199P 1999-02-24 1999-02-24
US60/121,651 1999-02-24

Publications (3)

Publication Number Publication Date
WO2000050563A2 WO2000050563A2 (en) 2000-08-31
WO2000050563A3 true WO2000050563A3 (en) 2000-12-21
WO2000050563A9 WO2000050563A9 (en) 2001-08-30

Family

ID=22397998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004416 WO2000050563A2 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors

Country Status (4)

Country Link
EP (1) EP1157097A4 (en)
JP (1) JP2002536989A (en)
CA (1) CA2364988A1 (en)
WO (1) WO2000050563A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4486187B2 (en) 1998-10-27 2010-06-23 武田薬品工業株式会社 Novel G protein-coupled receptor protein, its DNA and its ligand
US20020077469A1 (en) * 1999-03-10 2002-06-20 Borowsky Beth E. DNA encoding orphan SNORF11 receptor
CA2404257A1 (en) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Novel protein, dna thereof and process for producing the same
US20050075494A1 (en) * 2000-12-18 2005-04-07 Liu Qingyun Isolated nucleic acid molecules encoding a human and mouse g protein-coupled receptor-gpr54: encoded proteins, cells transformed therewith and uses thereof
WO2002072816A1 (en) * 2001-02-26 2002-09-19 Takeda Chemical Industries, Ltd. Novel mouse type kiss-1 receptor protein and dna thereof
JPWO2003030936A1 (en) * 2001-10-02 2005-01-20 住友製薬株式会社 Life-style related diseases or anorexia remedies and screening methods thereof
WO2004024072A2 (en) * 2002-09-11 2004-03-25 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
GB0304021D0 (en) * 2003-02-21 2003-03-26 Pfizer Ltd Treatment of hypertension
AU2004234399A1 (en) * 2003-04-28 2004-11-11 Wyeth Methods utilising G-protein coupled receptor 54
WO2005040833A1 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Regulation of human metastin recognising receptors
WO2006047302A1 (en) 2004-10-21 2006-05-04 Transtech Pharma, Inc. Bissulfonamide compounds as agonists of galr1, compositions, and methods of use
GB0719592D0 (en) * 2007-10-08 2007-11-14 Medical Res Council Compound, use and method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003548A1 (en) * 1996-07-19 1998-01-29 Astra Pharma Inc. A novel galanin receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4486187B2 (en) * 1998-10-27 2010-06-23 武田薬品工業株式会社 Novel G protein-coupled receptor protein, its DNA and its ligand

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003548A1 (en) * 1996-07-19 1998-01-29 Astra Pharma Inc. A novel galanin receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEE ET AL.: "Discovery of a receptor related to the galanin receptors", FEBS LETTERS, vol. 446, no. 1, 5 March 1999 (1999-03-05), pages 103 - 107, XP002931209 *
See also references of EP1157097A4 *

Also Published As

Publication number Publication date
JP2002536989A (en) 2002-11-05
EP1157097A4 (en) 2005-02-16
EP1157097A2 (en) 2001-11-28
WO2000050563A9 (en) 2001-08-30
WO2000050563A2 (en) 2000-08-31
CA2364988A1 (en) 2000-08-31

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