WO2001036471A3 - Endogenous and non-endogenous versions of human g protein-coupled receptors - Google Patents

Endogenous and non-endogenous versions of human g protein-coupled receptors Download PDF

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Publication number
WO2001036471A3
WO2001036471A3 PCT/US2000/031509 US0031509W WO0136471A3 WO 2001036471 A3 WO2001036471 A3 WO 2001036471A3 US 0031509 W US0031509 W US 0031509W WO 0136471 A3 WO0136471 A3 WO 0136471A3
Authority
WO
WIPO (PCT)
Prior art keywords
endogenous
human
protein
versions
coupled receptors
Prior art date
Application number
PCT/US2000/031509
Other languages
French (fr)
Other versions
WO2001036471A2 (en
Inventor
Ruoping Chen
Huong T Dang
Kevin P Lowitz
Original Assignee
Arena Pharm Inc
Ruoping Chen
Huong T Dang
Kevin P Lowitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU17696/01A priority Critical patent/AU782959B2/en
Application filed by Arena Pharm Inc, Ruoping Chen, Huong T Dang, Kevin P Lowitz filed Critical Arena Pharm Inc
Priority to EP00980434A priority patent/EP1242448A2/en
Priority to NZ518662A priority patent/NZ518662A/en
Priority to PCT/US2000/031509 priority patent/WO2001036471A2/en
Priority to CA002390547A priority patent/CA2390547A1/en
Priority to JP2001538960A priority patent/JP4768946B2/en
Priority to IL14956900A priority patent/IL149569A0/en
Priority to NZ531722A priority patent/NZ531722A/en
Priority to CNB00815869XA priority patent/CN1310945C/en
Publication of WO2001036471A2 publication Critical patent/WO2001036471A2/en
Publication of WO2001036471A3 publication Critical patent/WO2001036471A3/en
Priority to AU2005244540A priority patent/AU2005244540B2/en
Priority to AU2010201829A priority patent/AU2010201829B2/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown ('orphan GPCR receptors'), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
PCT/US2000/031509 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors WO2001036471A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2001538960A JP4768946B2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous forms of the human G protein coupled receptor
EP00980434A EP1242448A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
NZ518662A NZ518662A (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
CA002390547A CA2390547A1 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
AU17696/01A AU782959B2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
IL14956900A IL149569A0 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors
NZ531722A NZ531722A (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
CNB00815869XA CN1310945C (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human G protein-coupled receptors
AU2005244540A AU2005244540B2 (en) 1999-11-17 2005-12-15 Endogenous and non-endogenous versions of human G protein-coupled receptors
AU2010201829A AU2010201829B2 (en) 1999-11-17 2010-05-07 Endogenous and non-endogenous versions of human G protein-coupled receptors

Applications Claiming Priority (45)

Application Number Priority Date Filing Date Title
US16609999P 1999-11-17 1999-11-17
US16636999P 1999-11-17 1999-11-17
US16608899P 1999-11-17 1999-11-17
US60/166,099 1999-11-17
US60/166,369 1999-11-17
US60/166,088 1999-11-17
US17190299P 1999-12-23 1999-12-23
US17190199P 1999-12-23 1999-12-23
US17190099P 1999-12-23 1999-12-23
US60/171,902 1999-12-23
US60/171,900 1999-12-23
US60/171,901 1999-12-23
US18174900P 2000-02-11 2000-02-11
US60/181,749 2000-02-11
US18925800P 2000-03-14 2000-03-14
US18925900P 2000-03-14 2000-03-14
US60/189,259 2000-03-14
US60/189,258 2000-03-14
US19589800P 2000-04-10 2000-04-10
US19607800P 2000-04-10 2000-04-10
US19589900P 2000-04-10 2000-04-10
US60/195,898 2000-04-10
US60/195,899 2000-04-10
US60/196,078 2000-04-10
US20041900P 2000-04-28 2000-04-28
US60/200,419 2000-04-28
US20363000P 2000-05-12 2000-05-12
US60/203,630 2000-05-12
US21074100P 2000-06-12 2000-06-12
US21098200P 2000-06-12 2000-06-12
US60/210,982 2000-06-12
US60/210,741 2000-06-12
US22676000P 2000-08-21 2000-08-21
US60/226,760 2000-08-21
US23577900P 2000-09-26 2000-09-26
US23541800P 2000-09-26 2000-09-26
US60/235,779 2000-09-26
US60/235,418 2000-09-26
US24234300P 2000-10-20 2000-10-20
US24233200P 2000-10-20 2000-10-20
US60/242,343 2000-10-20
US60/242,332 2000-10-20
US24301900P 2000-10-24 2000-10-24
US60/243,019 2000-10-24
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors

Publications (2)

Publication Number Publication Date
WO2001036471A2 WO2001036471A2 (en) 2001-05-25
WO2001036471A3 true WO2001036471A3 (en) 2002-01-03

Family

ID=35884102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031509 WO2001036471A2 (en) 1999-11-17 2000-11-16 Endogenous and non-endogenous versions of human g protein-coupled receptors

Country Status (7)

Country Link
EP (1) EP1242448A2 (en)
CN (1) CN1310945C (en)
AU (3) AU782959B2 (en)
CA (1) CA2390547A1 (en)
IL (1) IL149569A0 (en)
NZ (2) NZ518662A (en)
WO (1) WO2001036471A2 (en)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
JP3307922B2 (en) 1999-09-14 2002-07-29 山之内製薬株式会社 Peptide leukotriene receptor
EP1233981A4 (en) * 1999-11-16 2003-02-12 Merck & Co Inc G-protein coupled receptor
EP1237909A2 (en) * 1999-11-16 2002-09-11 PHARMACIA & UPJOHN COMPANY Human g protein-coupled receptors
EP1242448A2 (en) * 1999-11-17 2002-09-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
WO2001049847A2 (en) * 1999-12-30 2001-07-12 Millennium Pharmaceuticals, Inc. 26904, 38911, and 39404, seven-transmembrane proteins/g-protein coupled receptors
WO2001059113A2 (en) * 2000-02-08 2001-08-16 Curagen Corporation G-protein coupled receptor proteins and nucleic acids encoding same
WO2001059109A1 (en) * 2000-02-08 2001-08-16 Millennium Pharmaceuticals, Inc. 39406 protein, a seven transmembrane protein
US6586205B1 (en) 2000-02-11 2003-07-01 Millennium Pharmaceuticals, Inc. 43239 a novel GPCR-like molecule and uses thereof
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
US20020064822A1 (en) * 2000-03-13 2002-05-30 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
AU2001244205A1 (en) * 2000-03-14 2001-09-24 Bayer Aktiengesellschaft Regulation of human p2y-like gpcr protein
AU2001242459A1 (en) * 2000-03-17 2001-09-24 Bayer Aktiengesellschaft Regulation of human substance p-like g protein-coupled receptor
US20040136981A1 (en) * 2000-03-20 2004-07-15 Shyam Ramakrishnan Regulation of human histamine h2-like g protein-coupled receptor
AU2001242485A1 (en) * 2000-03-20 2001-10-03 Bayer Aktiengesellschaft Regulation of human serotonin-like g protein-coupled receptor
GB2364308A (en) * 2000-03-23 2002-01-23 Smithkline Beecham Corp AXOR64, a G-protein coupled receptor polypeptide and its encoding polynucleotide sequence
EP1268548A2 (en) * 2000-03-24 2003-01-02 Bayer Aktiengesellschaft Regulation of human rta-like g protein-coupled receptor
WO2001074904A2 (en) * 2000-03-31 2001-10-11 Curagen Corporation G-protein coupled receptors and nucleic acids encoding same
WO2001077320A2 (en) * 2000-04-05 2001-10-18 Bayer Aktiengesellschaft Regulation of human hm74-like g protein coupled receptor
GB0008504D0 (en) * 2000-04-05 2000-05-24 Pfizer Ltd Novel polypeptide
EP1268546A2 (en) * 2000-04-06 2003-01-02 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
EP1274841A2 (en) * 2000-04-07 2003-01-15 Bayer Aktiengesellschaft Regulation of human cyslt2-like gpcr protein
EP1303603A2 (en) * 2000-04-19 2003-04-23 PHARMACIA & UPJOHN COMPANY G protein-coupled receptor con-218
US20030092035A1 (en) 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7691604B1 (en) 2000-05-04 2010-04-06 California Institute Of Technology MRG polypeptides and nucleic acids encoding the same
US7510845B2 (en) 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
GB2365012A (en) * 2000-05-11 2002-02-13 Smithkline Beecham Corp G protein coupled receptor AXOR89
AU2001269014A1 (en) * 2000-05-18 2001-11-26 Bayer Aktiengesellschaft Regulation of human follicle stimulating hormone-like g protein-coupled receptor
JP2005506031A (en) * 2000-05-18 2005-03-03 アプレラ コーポレーション Isolated human G-protein coupled receptor, nucleic acid molecule encoding human GPCR protein, and uses thereof
EP1158002A1 (en) * 2000-05-19 2001-11-28 Pfizer Limited Human G-protein coupled receptor
EP1309623A2 (en) * 2000-05-22 2003-05-14 Millenium Pharmaceuticals, Inc. G protein-coupled receptors from human clone "26908" and uses thereof
US20030152973A1 (en) * 2000-05-24 2003-08-14 Grassie Morag A G-protein coupled receptor org3
EP1292677A2 (en) * 2000-06-05 2003-03-19 Bayer Aktiengesellschaft Human hm74-like g protein coupled receptor
US20040071695A1 (en) * 2000-06-06 2004-04-15 Franz-Werner Kluxen Novel g-protein coupled receptor
AU2001265717A1 (en) * 2000-06-20 2002-01-02 Euroscreen S.A. A recombinant cell line expressing gpcrx11 as a functional receptor validated byangiopeptin and useful for screening of agonists and antagonists
CA2413454A1 (en) * 2000-06-21 2001-12-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung A g-protein coupled receptor
AU2001287574A1 (en) * 2000-06-30 2002-01-08 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr20, and uses thereof
AU2001283914A1 (en) * 2000-06-30 2002-01-14 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr27, and uses therof
GB2367297A (en) * 2000-07-07 2002-04-03 Smithkline Beecham Corp AXOR95 polypeptides and polynucleotides
US20040248321A1 (en) * 2000-07-07 2004-12-09 Takeo Moriya Novel g protein-coupled receptor protein and dna thereof
IL144655A0 (en) * 2000-08-04 2002-05-23 Switch Biotech Ag Polypeptides or nucleic acids encoding of a family of g-protein coupled receptors and their use
AU2001283254A1 (en) * 2000-08-10 2002-02-25 Amgen Inc. Leucine-rich repeat-containing G-protein coupled receptor-8 molecules and uses thereof
EP1688496A3 (en) * 2000-08-14 2006-08-16 Actimis Pharmaceuticals, Inc., Regulation of human P2Y1-like G protein-coupled receptor
DK1311677T3 (en) * 2000-08-14 2006-05-22 Actimis Pharmaceuticals Inc Regulation of human P2Y-1-like G protein-coupled receptor
US20030032019A1 (en) * 2000-08-15 2003-02-13 Peter Lind Novel G protein-coupled receptors
WO2002016607A1 (en) * 2000-08-24 2002-02-28 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
AU2001286877A1 (en) * 2000-08-29 2002-03-13 Millennium Pharmaceuticals, Inc. 57242, a novel human g protein-coupled receptor family member and uses therefor
WO2002026824A2 (en) * 2000-09-27 2002-04-04 Bristol-Myers Squibb Company A novel human g-protein coupled receptor, hgprbmy5, expressed highly in brain and ovarian tissues
US20040076951A1 (en) * 2000-10-25 2004-04-22 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
EP1332157A2 (en) 2000-11-03 2003-08-06 The Regents of the University of California Prokineticin polypeptides, related compositions and methods
US7531310B2 (en) 2000-11-17 2009-05-12 Bristol-Myers Squibb Company Methods of diagnosing Crohn's disease by measuring expression level of RNA encoding human G-protein coupled receptor, HGPRBMY11
US7312086B2 (en) * 2000-12-07 2007-12-25 Bristol-Myers Squibb Company Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
EP1219638A3 (en) * 2000-12-18 2002-07-24 Pfizer Limited G-protein coupled receptors having homology to the P2Y purinoreceptor 1 (P2Y1)
WO2002057441A1 (en) * 2001-01-18 2002-07-25 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2002059304A1 (en) * 2001-01-23 2002-08-01 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
EP1358328A2 (en) * 2001-01-26 2003-11-05 Bayer Aktiengesellschaft Regulation of human serotonin-like g protein-coupled recepter
WO2002059151A2 (en) * 2001-01-26 2002-08-01 Pe Corporation (Ny) Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
WO2002072829A1 (en) * 2001-01-31 2002-09-19 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
JP2005503111A (en) * 2001-02-07 2005-02-03 インサイト・ゲノミックス・インコーポレイテッド G protein coupled receptor
WO2002064789A1 (en) * 2001-02-14 2002-08-22 Pharmacia & Upjohn Company Protein-coupled receptor
US20030171541A1 (en) * 2001-02-14 2003-09-11 Amgen Inc., A Corporation Of The State Of Delaware G-protein coupled receptor molecules and uses thereof
FR2823762A1 (en) * 2001-04-24 2002-10-25 Servier Lab New nucleic acid encoding G protein-coupled receptor, useful for identifying specific modulators, potentially useful for treating e.g. diabetes
AU2002307903A1 (en) * 2001-05-01 2002-11-11 Paradigm Therapeutics Limited G-protein coupled receptor
EP1588139A4 (en) * 2001-05-31 2006-10-04 Merck & Co Inc Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
WO2002101005A2 (en) * 2001-06-07 2002-12-19 Wyeth A g-protein coupled receptor and uses therefor
EP1458847A4 (en) * 2001-06-19 2005-10-26 Regeneron Pharma Novel nucleic acids, polypeptides, methods of making, and uses thereof
US20040175789A1 (en) * 2001-06-26 2004-09-09 Umesh Bhatia G protein coupled receptors and dna sequences thereof
DK1399744T3 (en) * 2001-06-27 2008-09-22 Janssen Pharmaceutica Nv EPF receptor assays, compounds, and therapeutic preparations
WO2003004530A1 (en) * 2001-07-06 2003-01-16 Bayer Aktiengesellschaft Regulation of human somatostatin receptor-like protein
US20030096751A1 (en) * 2001-08-20 2003-05-22 Ramanathan Chandra S. G-protein coupled receptor polynucleotides and methods of use thereof
CA2467206A1 (en) * 2001-11-16 2003-05-30 Wyeth Genes encoding g-protein coupled receptors and methods of use therefor
EP1474176A4 (en) * 2001-11-26 2005-06-15 Bristol Myers Squibb Co Novel human g-protein coupled receptor, hgprbmy31, and variants and methods of use thereof
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
RU2004125608A (en) * 2002-01-23 2005-04-20 Авентис Фармасьютикалз Инк. (Us) NUCLEIC ACID ENCODING A RECEPTOR RELATED TO A G-PROTEIN AND ITS APPLICATION
WO2003078466A1 (en) * 2002-03-19 2003-09-25 Tanabe Seiyaku Co., Ltd. Novel g protein-coupled recepotrs and genes thereof
US7527935B2 (en) 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
US20060073516A1 (en) * 2002-03-28 2006-04-06 Yasuaki Ito Novel screening method
DE10225443A1 (en) * 2002-06-08 2003-12-18 Aventis Pharma Gmbh Binding assay for identifying compounds that react with the mas-like-1 receptor, useful for treating cardiovascular disease, including activators and inhibitors
CA2500587A1 (en) 2002-10-04 2004-04-22 The Regents Of The University Of California Screening and therapeutic methods relating to neurogenesis
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
US7189524B1 (en) 2002-11-25 2007-03-13 Amgen, Inc. Receptor ligands and methods of modulating receptors
EP1603585A2 (en) 2003-03-14 2005-12-14 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
CA2543127A1 (en) * 2003-10-31 2005-05-12 The Regents Of The University Of California Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
US7189539B2 (en) 2003-11-25 2007-03-13 Bristol-Myers Squibb Company Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
WO2005059545A2 (en) * 2003-12-12 2005-06-30 Bayer Healthcare Ag Diagnostics ans therapeutics for diseases associated with g protein-coupled receptor gpr82 (gpr82)
US7893197B2 (en) 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
PE20070097A1 (en) 2005-06-28 2007-03-08 Merck Sharp & Dohme NIACIN RECEPTOR AGONISTS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS
TW200817681A (en) 2006-05-31 2008-04-16 Arena Pharm Inc Use of GPR101 receptor in methods to identify modulators of hypothalamic proopiomelanocortin (POMC)-derived biologically active peptide secretion useful in the treatment of POMC-derived biologically active peptide-related disorders
WO2008063321A2 (en) 2006-10-13 2008-05-29 Janssen Pharmaceutica N.V. Gpr81-ligand complexes and their preparation and use
WO2008085888A1 (en) * 2007-01-05 2008-07-17 Arena Pharmaceuticals, Inc. G protein-coupled receptor and modulators thereof for the treatment of gaba-related neurological disorders including sleep-related disorders
GB2447786C (en) 2007-03-22 2011-11-09 Heptares Therapeutics Ltd Mutant G-protein coupled receptor proteins and methods for selecting them
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
WO2014078306A1 (en) 2012-11-13 2014-05-22 Regeneron Pharmaceuticals, Inc. Anti-prokineticin receptor (prokr) antibodies and uses thereof

Citations (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0612845A2 (en) * 1993-02-26 1994-08-31 American Cyanamid Company Purified opioid receptor
WO1996005302A1 (en) * 1994-08-11 1996-02-22 Takeda Chemical Industries, Ltd. G protein coupled receptor protein, production, and use thereof
JPH08245697A (en) * 1995-03-16 1996-09-24 Takeda Chem Ind Ltd Novel g protein-conjugated receptor protein, its production and use
WO1997021731A1 (en) * 1995-12-11 1997-06-19 New England Medical Center Hospitals, Inc. Assay for and uses of peptide hormone receptor ligands
WO1998029439A1 (en) * 1996-12-27 1998-07-09 Merck & Co., Inc. Galanin receptor galr2 and nucleotides encoding same
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
EP0878542A2 (en) * 1997-04-22 1998-11-18 Smithkline Beecham Corporation cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
WO1998056820A1 (en) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Hm74a receptor
US5861309A (en) * 1992-09-25 1999-01-19 Synaptic Pharmaceutical Corporation DNA endoding human alpha 1 adrenergic receptors
EP0892051A2 (en) * 1997-06-18 1999-01-20 Smithkline Beecham Corporation CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
JPH1132770A (en) * 1997-07-24 1999-02-09 Asahi Chem Ind Co Ltd Seven-transmembrane type receptor protein jeg62
WO1999006552A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN
WO1999032519A1 (en) * 1997-12-22 1999-07-01 Astrazeneca Canada Inc. Novel g protein-coupled receptor
WO1999048921A1 (en) * 1998-03-26 1999-09-30 The Board Of Trustees Of The Leland Stanford Junior University Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions
WO2000014229A1 (en) * 1998-09-03 2000-03-16 Asahi Kasei Kabushiki Kaisha Novel receptor protein and method for diagnosing inflammatory diseases by using the same
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000049046A1 (en) * 1999-02-19 2000-08-24 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001007606A1 (en) * 1999-07-27 2001-02-01 Smithkline Beecham Plc Axor21, a g-protein coupled receptor
WO2001009184A1 (en) * 1999-07-15 2001-02-08 Solvay Pharmaceuticals B.V. Human g-protein coupled receptor
WO2001012673A1 (en) * 1999-08-17 2001-02-22 Merck Patent Gmbh Pgpcr-3 polypeptides and dna sequences thereof
WO2001014577A1 (en) * 1999-08-24 2001-03-01 Smithkline Beecham Corporation Molecular cloning of a galanin like 7tm receptor (axor40)
WO2001016159A1 (en) * 1999-08-27 2001-03-08 Smithkline Beecham Corporation Gpcr, theant
EP1090989A1 (en) * 1999-10-08 2001-04-11 Pfizer Limited Human g-protein-coupled receptor
EP1094076A1 (en) * 1999-10-21 2001-04-25 Pfizer Limited Human G-protein coupled receptor
WO2001031014A2 (en) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company G protein-coupled receptors expressed in human brain
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Patent Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861309A (en) * 1992-09-25 1999-01-19 Synaptic Pharmaceutical Corporation DNA endoding human alpha 1 adrenergic receptors
EP0612845A2 (en) * 1993-02-26 1994-08-31 American Cyanamid Company Purified opioid receptor
WO1996005302A1 (en) * 1994-08-11 1996-02-22 Takeda Chemical Industries, Ltd. G protein coupled receptor protein, production, and use thereof
JPH08245697A (en) * 1995-03-16 1996-09-24 Takeda Chem Ind Ltd Novel g protein-conjugated receptor protein, its production and use
WO1997021731A1 (en) * 1995-12-11 1997-06-19 New England Medical Center Hospitals, Inc. Assay for and uses of peptide hormone receptor ligands
WO1998029439A1 (en) * 1996-12-27 1998-07-09 Merck & Co., Inc. Galanin receptor galr2 and nucleotides encoding same
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
US5891720A (en) * 1997-04-17 1999-04-06 Millennium Pharmaceuticals, Inc. Isolated DNA encoding a novel human G-protein coupled receptor
EP0878542A2 (en) * 1997-04-22 1998-11-18 Smithkline Beecham Corporation cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor
WO1998056820A1 (en) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Hm74a receptor
EP0892051A2 (en) * 1997-06-18 1999-01-20 Smithkline Beecham Corporation CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
JPH1198988A (en) * 1997-06-18 1999-04-13 Smithkline Beecham Corp Complementary dna clone heoda54 encoding human 7 membrane passing receptor
US5955308A (en) * 1997-06-18 1999-09-21 Smithkline Beecham Corporation cDNA clone HEAOD54 that encodes a human 7-transmembrane receptor
JPH1132770A (en) * 1997-07-24 1999-02-09 Asahi Chem Ind Co Ltd Seven-transmembrane type receptor protein jeg62
WO1999006552A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN
WO1999032519A1 (en) * 1997-12-22 1999-07-01 Astrazeneca Canada Inc. Novel g protein-coupled receptor
WO1999048921A1 (en) * 1998-03-26 1999-09-30 The Board Of Trustees Of The Leland Stanford Junior University Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions
WO2000014229A1 (en) * 1998-09-03 2000-03-16 Asahi Kasei Kabushiki Kaisha Novel receptor protein and method for diagnosing inflammatory diseases by using the same
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000049046A1 (en) * 1999-02-19 2000-08-24 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001009184A1 (en) * 1999-07-15 2001-02-08 Solvay Pharmaceuticals B.V. Human g-protein coupled receptor
WO2001007606A1 (en) * 1999-07-27 2001-02-01 Smithkline Beecham Plc Axor21, a g-protein coupled receptor
WO2001012673A1 (en) * 1999-08-17 2001-02-22 Merck Patent Gmbh Pgpcr-3 polypeptides and dna sequences thereof
WO2001014577A1 (en) * 1999-08-24 2001-03-01 Smithkline Beecham Corporation Molecular cloning of a galanin like 7tm receptor (axor40)
WO2001016159A1 (en) * 1999-08-27 2001-03-08 Smithkline Beecham Corporation Gpcr, theant
EP1090989A1 (en) * 1999-10-08 2001-04-11 Pfizer Limited Human g-protein-coupled receptor
EP1094076A1 (en) * 1999-10-21 2001-04-25 Pfizer Limited Human G-protein coupled receptor
WO2001031014A2 (en) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company G protein-coupled receptors expressed in human brain
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
BOYER JOSE L ET AL: "Molecular cloning and expression of an avian G protein-coupled P2Y receptor.", MOLECULAR PHARMACOLOGY, vol. 52, no. 6, December 1997 (1997-12-01), pages 928 - 934, XP002175907, ISSN: 0026-895X *
DATABASE EMBL 1 December 1999 (1999-12-01), BIRREN B. ET AL.: "Homo sapiens clone RP11-14N15", XP002175784 *
DATABASE EMBL 1 October 2000 (2000-10-01), COLLIER R.: "DJ680N.3 (G-Protein Coupled Receptors) (Fragment)", XP002168498 *
DATABASE EMBL 15 July 1998 (1998-07-15), WEINSHANK R. H.: "5-Hydroxytryptamine 1B Receptor(-HT-1B) (Serotonin Receptor)", XP002175948 *
DATABASE EMBL 16 April 2000 (2000-04-16), BURTON J. ET AL.: "Human DNA sequence from clone RP11-163L4", XP002175911 *
DATABASE EMBL 18 May 1999 (1999-05-18), ZHAO S ET AL.: "Use of BAC End Sequences from Library RPCI-11 for Sequence-Ready Map Building", XP002175779 *
DATABASE EMBL 18 October 1999 (1999-10-18), BIRREN B., LINTON L., NUSBAUM C., LANDER E.: "Homo sapiens clone RP11-15H8, 31 unordered pieces.", XP002175781 *
DATABASE EMBL 22 February 2001 (2001-02-22), JEFFREY L.M.D.D. AND BERGSUMA W.S.H.H.: "cDNA clone HeoAd54 encoding human seven-pass transmembrane receptor" *
DATABASE EMBL 23 April 1999 (1999-04-23), STONE ET AL.: "Homo sapiens chomosome 4, 16 unordered pieces", XP002175914 *
DATABASE EMBL 24 April 2000 (2000-04-24), ABOLA A.P. ET AL.: "omo sapiens chromosome 13 clone RP11-286P8, complete sequence", XP002175912 *
DATABASE EMBL 27 April 2000 (2000-04-27), BIRREN B. ET AL.: "Homo sapiens chromosome 11, clone RP11-589F4", XP002175913 *
DATABASE EMBL 29 May 1999 (1999-05-29), GEMPSCPÜE: "Drosophila melanogaster genome survey sequence TET3 end of BAC # BACR08K10 of RPCI-98 library from Drosophila melanogaster (fruit fly)", XP002175910 *
DATABASE EMBL 29 September 1999 (1999-09-29), WATERSON R.H.: "Homo sapiens chromosome 2 clone RP11-510C1", XP002175915 *
DATABASE EMBL 3 December 1999 (1999-12-03), HATTORI M. ET AL.: "Homo sapiens 171,539 genomic of 11q13", XP002175780 *
DATABASE EMBL 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE: "Homo sapiens chomosome 19 clone CTD-3023J11, complete sequence", XP002175778 *
DATABASE EMBL 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE: "Sequencing of Human Chromosome 5", XP002175776 *
DATABASE EMBL 4 May 2000 (2000-05-04), OHONO ET AL.: "Homo spiens mRNA for G proteine-coupled receptor C5L2, complete cds", XP002175947 *
DATABASE EMBL 5 May 2000 (2000-05-05), WALLIS, J: "Human DNA sequence from clone RP5-1160K1", XP002175782 *
DATABASE EMBL 7 January 2000 (2000-01-07), BURTON J: "Human DNA sequence from clone RP11-159O9", XP002175785 *
DATABASE EMBL ADAMS M.D. ET AL.: "CIT-HSP-2286K19.TF CIT-HSP Homo sapiens genomic clone 2286K19, genomic survey sequence", XP002175783 *
DATABASE EMBL HEISE C.E. ET AL.: "Homo sapiens cysteinyl leukotriene receptor CYSLT2 gene, complete cds." *
DATABASE EMBL OE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER.: "Homo sapiens chromosome 5 clone CTC-502M5, complete sequence.", XP002175786 *
HEISE CHRISTOPHER E ET AL: "Characterization of the human cysteinyl leukotriene 2 receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 39, 29 September 2000 (2000-09-29), pages 30531 - 30536, XP002175775, ISSN: 0021-9258 *
KJELSBERG M A ET AL: "Constitutive activation of the alpha1B-adrenergic receptor by all amino acid substitutions at a single site", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 267, no. 3, 25 January 1992 (1992-01-25), pages 1430 - 1433, XP002135768, ISSN: 0021-9258 *
MAHAIRAS GREGORY G ET AL: "Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 17, 17 August 1999 (1999-08-17), Aug. 17, 1999, pages 9739 - 9744, XP002175909, ISSN: 0027-8424 *
MARCHESE A ET AL: "Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology", TRENDS IN PHARMACOLOGICAL SCIENCES,GB,ELSEVIER TRENDS JOURNAL, CAMBRIDGE, vol. 20, no. 9, 1 September 1999 (1999-09-01), pages 370 - 375, XP004178194, ISSN: 0165-6147 *
O'DOWD B F ET AL: "DISCOVERY OF THREE NOVEL G-PROTEIN-COUPLED RECEPTOR GENES", GENOMICS,ACADEMIC PRESS, SAN DIEGO,US, vol. 47, no. 2, 15 January 1998 (1998-01-15), pages 310 - 313, XP000863786, ISSN: 0888-7543 *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 09 30 July 1999 (1999-07-30) *
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES,GB,ELSEVIER TRENDS JOURNAL, CAMBRIDGE, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147 *

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