EP0892051A2 - CDNA Clone heoad54 that encodes a human 7 transmembrane receptor - Google Patents
CDNA Clone heoad54 that encodes a human 7 transmembrane receptor Download PDFInfo
- Publication number
- EP0892051A2 EP0892051A2 EP98304192A EP98304192A EP0892051A2 EP 0892051 A2 EP0892051 A2 EP 0892051A2 EP 98304192 A EP98304192 A EP 98304192A EP 98304192 A EP98304192 A EP 98304192A EP 0892051 A2 EP0892051 A2 EP 0892051A2
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- EP
- European Patent Office
- Prior art keywords
- heoad54
- polypeptide
- seq
- nucleotide sequence
- receptor
- Prior art date
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
The differences in the cDNA or genomic sequence between affected and unaffected individuals can also be determined. If a mutation is observed in some or all of the affected individuals but not in any normal individuals, then the mutation is likely to be the causative agent of the disease.
Claims (20)
- An isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity over its entire length to a nucleotide sequence encoding the HEOAD54 polypeptide of SEQ ID NO:2; or a nucleotide sequence complementary to said isolated polynucleotide.
- The polynucleotide of claim 1 wherein said polynucleotide comprises the nucleotide sequence contained in SEQ ID NO:1 encoding the HEOAD54 polypeptide of SEQ ID NO2.
- The polynucleotide of claim 1 wherein said polynucleotide comprises a nucleotide sequence that is at least 80% identical to that of SEQ ID NO: 1 over its entire length.
- The polynucleotide of claim 3 which is polynucleotide of SEQ ID NO: 1.
- The polynucleotide of claim 1 which is DNA or RNA.
- A DNA or RNA molecule comprising an expression system, wherein said expression system is capable of producing an HEOAD54 polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide of SEQ ID NO:2 when said expression system is present in a compatible host cell.
- A host cell comprising the expression system of claim 6.
- A process for producing an HEOAD54 polypeptide comprising culturing a host of claim 7 under conditions sufficient for the production of said polypeptide and recovering the polypeptide from the culture.
- A process for producing a cell which produces an HEOAD54 polypeptide thereof comprising transforming or transfecting a host cell with the expression system of claim 6 such that the host cell, under appropriate culture conditions, produces an HEOAD54 polypeptide.
- An IIEOAD54 polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO:2 over its entire length.
- The polypeptide of claim 10 which comprises the amino acid sequence of SEQ ID NO:2.
- An antibody immunospecific for the HEOAD54 polypeptide of claim 10.
- A method for the treatment of a subject in need of enhanced activity or expression of the HEOAD54 polypeptide of claim 10 comprising:(a) administering to the subject a therapeutically effective amount of an agonist to said receptor; and/or(b) providing to the subject an isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity to a nucleotide sequence encoding the HEOAD54 polypeptide of SEQ ID NO:2 over its entire length; or a nucleotide sequence complementary to said nucleotide sequence in a form so as to effect production of said receptor activity in vivo.
- A method for the treatment of a subject having need to inhibit activity or expression of the HEOAD54 polypeptide of claim 10 comprising:(a) administering to the subject a therapeutically effective amount of an antagonist to said receptor; and/or(b) administering to the subject a nucleic acid molecule that inhibits the expression of the nucleotide sequence encoding said receptor; and/or(c) administering to the subject a therapeutically effective amount of a polypeptide that competes with said receptor for its ligand.
- A process for diagnosing a disease or a susceptibility to a disease in a subject related to expression or activity of the HEOAD54 polypeptide of claim 10 in a subject comprising:(a) determining the presence or absence of a mutation in the nucleotide sequence encoding said HEOAD54 polypeptide in the genome of said subject; and/or(b) analyzing for the presence or amount of the HEOAD54 polypeptide expression in a sample derived from said subject.
- A method for identifying agonists to the HEOAD54 polypeptide of claim 10 comprising:(a) contacting a cell which produces an HEOAD54 polypeptide with a candidate compound; and(b) determining whether the candidate compound effects a signal generated by activation of the HEOAD54 polypeptide.
- An agonist identified by the method of claim 16.
- The method for identifying antagonists to the HEOAD54 polypeptide of claim 10 comprising:(a) contacting a cell which produces an HEOAD54 polypeptide with an agonist; and(b) determining whether the signal generated by said agonist is diminished in the presence of a candidate compound.
- An antagonist identified by the method of claim 18.
- A recombinant host cell produced by a method of Claim 9 or a membrane thereof expressing an HEOAD54 polypeptide.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5012497P | 1997-06-18 | 1997-06-18 | |
US60124P | 1997-06-18 | ||
US08/955,713 US5955308A (en) | 1997-06-18 | 1997-10-23 | cDNA clone HEAOD54 that encodes a human 7-transmembrane receptor |
US955713 | 1997-10-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0892051A2 true EP0892051A2 (en) | 1999-01-20 |
EP0892051A3 EP0892051A3 (en) | 2000-01-05 |
Family
ID=26727910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98304192A Withdrawn EP0892051A3 (en) | 1997-06-18 | 1998-05-27 | CDNA Clone heoad54 that encodes a human 7 transmembrane receptor |
Country Status (3)
Country | Link |
---|---|
US (1) | US5955308A (en) |
EP (1) | EP0892051A3 (en) |
JP (2) | JPH1198988A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001031014A2 (en) * | 1999-10-27 | 2001-05-03 | Pharmacia & Upjohn Company | G protein-coupled receptors expressed in human brain |
WO2001062798A2 (en) * | 2000-02-25 | 2001-08-30 | Pharmacia & Upjohn Company | G protein-coupled receptors |
WO2001062797A2 (en) * | 2000-02-23 | 2001-08-30 | Pharmacia & Upjohn Company | G protein-coupled receptors |
WO2001068702A2 (en) * | 2000-03-16 | 2001-09-20 | Bayer Aktiengesellschaft | Regulation of human g protein-coupled receptor |
WO2001094385A2 (en) * | 2000-06-05 | 2001-12-13 | Bayer Aktiengesellschaft | Human hm74-like g protein coupled receptor |
WO2001036471A3 (en) * | 1999-11-17 | 2002-01-03 | Arena Pharm Inc | Endogenous and non-endogenous versions of human g protein-coupled receptors |
WO2002016636A2 (en) * | 2000-08-24 | 2002-02-28 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders |
US6555339B1 (en) | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
WO2003078466A1 (en) * | 2002-03-19 | 2003-09-25 | Tanabe Seiyaku Co., Ltd. | Novel g protein-coupled recepotrs and genes thereof |
WO2004073586A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor tg1019 (tg1019) |
US6902902B2 (en) | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
US7119190B2 (en) | 1997-04-14 | 2006-10-10 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human G protein-coupled receptors |
US7527935B2 (en) | 2002-03-19 | 2009-05-05 | Mitsubishi Tanabe Pharma Corporation | G-protein coupled receptor having eicosanoid as ligand and gene thereof |
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DE69840568D1 (en) * | 1997-04-14 | 2009-04-02 | Arena Pharm Inc | METHOD FOR IDENTIFYING MODULATORS OF CELL SURFACE MEMBRANE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASES |
US20030139588A9 (en) * | 1998-10-13 | 2003-07-24 | Ruoping Chen | Endogenous and non-endogenous versions of human G protein-coupled receptors |
US20040137563A9 (en) * | 1998-10-13 | 2004-07-15 | Ruoping Chen | Endogenous and non-endogenous versions of human G protein-coupled receptors |
EP1379656A2 (en) * | 2001-02-14 | 2004-01-14 | Amgen Inc. | G-protein coupled receptor molecules and uses thereof |
EP1404716A2 (en) * | 2001-06-26 | 2004-04-07 | Novartis AG | Novel g protein-coupled receptors and dna sequences thereof |
GB0210597D0 (en) * | 2002-01-23 | 2002-06-19 | Aventis Pharma Inc | A nucleic acid encoding a G-protein-coupled receptor,and uses thereof |
US20030139343A1 (en) * | 2002-12-04 | 2003-07-24 | Shyam Ramakrishnan | Regulation of human hm74-like g protein coupled receptor |
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1997
- 1997-10-23 US US08/955,713 patent/US5955308A/en not_active Expired - Fee Related
-
1998
- 1998-05-27 EP EP98304192A patent/EP0892051A3/en not_active Withdrawn
- 1998-06-18 JP JP10171139A patent/JPH1198988A/en active Pending
-
2001
- 2001-10-04 JP JP2001308726A patent/JP2002191374A/en active Pending
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US6555339B1 (en) | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
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WO2001031014A3 (en) * | 1999-10-27 | 2002-06-06 | Upjohn Co | G protein-coupled receptors expressed in human brain |
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AU2010201829B2 (en) * | 1999-11-17 | 2011-11-03 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human G protein-coupled receptors |
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WO2001062797A3 (en) * | 2000-02-23 | 2002-10-24 | Upjohn Co | G protein-coupled receptors |
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WO2001068702A3 (en) * | 2000-03-16 | 2002-05-30 | Bayer Ag | Regulation of human g protein-coupled receptor |
WO2001068702A2 (en) * | 2000-03-16 | 2001-09-20 | Bayer Aktiengesellschaft | Regulation of human g protein-coupled receptor |
WO2001094385A2 (en) * | 2000-06-05 | 2001-12-13 | Bayer Aktiengesellschaft | Human hm74-like g protein coupled receptor |
WO2001094385A3 (en) * | 2000-06-05 | 2002-05-10 | Bayer Ag | Human hm74-like g protein coupled receptor |
WO2002016636A2 (en) * | 2000-08-24 | 2002-02-28 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders |
WO2002016636A3 (en) * | 2000-08-24 | 2003-10-09 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders |
US6902902B2 (en) | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
US7829298B2 (en) | 2001-11-27 | 2010-11-09 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors for metabolic-related disorders |
US7527935B2 (en) | 2002-03-19 | 2009-05-05 | Mitsubishi Tanabe Pharma Corporation | G-protein coupled receptor having eicosanoid as ligand and gene thereof |
WO2003078466A1 (en) * | 2002-03-19 | 2003-09-25 | Tanabe Seiyaku Co., Ltd. | Novel g protein-coupled recepotrs and genes thereof |
WO2004073586A3 (en) * | 2003-02-19 | 2005-01-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor tg1019 (tg1019) |
WO2004073586A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor tg1019 (tg1019) |
Also Published As
Publication number | Publication date |
---|---|
EP0892051A3 (en) | 2000-01-05 |
JP2002191374A (en) | 2002-07-09 |
US5955308A (en) | 1999-09-21 |
JPH1198988A (en) | 1999-04-13 |
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