WO2001031014A3 - G protein-coupled receptors expressed in human brain - Google Patents

G protein-coupled receptors expressed in human brain Download PDF

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Publication number
WO2001031014A3
WO2001031014A3 PCT/US2000/029601 US0029601W WO0131014A3 WO 2001031014 A3 WO2001031014 A3 WO 2001031014A3 US 0029601 W US0029601 W US 0029601W WO 0131014 A3 WO0131014 A3 WO 0131014A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
coupled receptors
human brain
receptors expressed
genes
Prior art date
Application number
PCT/US2000/029601
Other languages
French (fr)
Other versions
WO2001031014A2 (en
Inventor
Gabriel Vogeli
Linda S Wood
Kalpana Merchant
Original Assignee
Upjohn Co
Gabriel Vogeli
Linda S Wood
Kalpana Merchant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Gabriel Vogeli, Linda S Wood, Kalpana Merchant filed Critical Upjohn Co
Priority to EP00978278A priority Critical patent/EP1230361A2/en
Priority to AU15756/01A priority patent/AU1575601A/en
Priority to CA002386509A priority patent/CA2386509A1/en
Publication of WO2001031014A2 publication Critical patent/WO2001031014A2/en
Publication of WO2001031014A3 publication Critical patent/WO2001031014A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides genes encoding heretofore unknown G protein-coupled receptors, constructs and recombinant host cells incorporating the genes; the GPCR polypeptides encoded by the genes; antibodies to the polypeptides; and methods of making and using all of the foregoing.
PCT/US2000/029601 1999-10-27 2000-10-27 G protein-coupled receptors expressed in human brain WO2001031014A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00978278A EP1230361A2 (en) 1999-10-27 2000-10-27 G protein-coupled receptors expressed in human brain
AU15756/01A AU1575601A (en) 1999-10-27 2000-10-27 G protein-coupled receptors expressed in brain
CA002386509A CA2386509A1 (en) 1999-10-27 2000-10-27 G protein-coupled receptors expressed in human brain

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US42765399A 1999-10-27 1999-10-27
US42802099A 1999-10-27 1999-10-27
US42785999A 1999-10-27 1999-10-27
US42811499A 1999-10-27 1999-10-27
US09/428,114 1999-10-27
US09/427,859 1999-10-27
US09/428,020 1999-10-27
US09/427,653 1999-10-27
US42969599A 1999-10-28 1999-10-28
US42951799A 1999-10-28 1999-10-28
US42955599A 1999-10-28 1999-10-28
US42967699A 1999-10-28 1999-10-28
US09/429,517 1999-10-28
US09/429,555 1999-10-28
US09/429,695 1999-10-28
US09/429,676 1999-10-28
US45439999A 1999-12-03 1999-12-03
US09/454,399 1999-12-03
US48179400A 2000-01-12 2000-01-12
US09/481,794 2000-01-12

Publications (2)

Publication Number Publication Date
WO2001031014A2 WO2001031014A2 (en) 2001-05-03
WO2001031014A3 true WO2001031014A3 (en) 2002-06-06

Family

ID=27581260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029601 WO2001031014A2 (en) 1999-10-27 2000-10-27 G protein-coupled receptors expressed in human brain

Country Status (4)

Country Link
EP (1) EP1230361A2 (en)
AU (1) AU1575601A (en)
CA (1) CA2386509A1 (en)
WO (1) WO2001031014A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
EP1157038A4 (en) * 1999-02-26 2005-01-19 Smithkline Beecham Corp Cloning of a p2y-like 7tm receptor (axor17)
US7361338B2 (en) 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
US6790631B1 (en) 1999-10-05 2004-09-14 Agensys, Inc. G protein-coupled receptor up-regulated in prostate cancer and uses thereof
IL149569A0 (en) * 1999-11-17 2002-11-10 Arena Pharm Inc Endogenous and non-endogenous versions of human g protein-coupled receptors
GB0001700D0 (en) * 2000-01-25 2000-03-15 Glaxo Group Ltd Novel protein
AU2001264721A1 (en) * 2000-05-18 2001-11-26 Incyte Genomics, Inc. G-protein coupled receptors
WO2001088127A2 (en) * 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Regulation of human follicle stimulating hormone-like g protein-coupled receptor
AU6604901A (en) * 2000-06-05 2001-12-17 Bayer Aktiengesellschaft Regulation of human hm74-like g protein coupled receptor
US20030212255A1 (en) * 2000-07-26 2003-11-13 Muralidhara Padigaru Novel proteins and nucleic acids encoding same
JP2005503137A (en) * 2001-06-26 2005-02-03 ノバルティス アクチエンゲゼルシャフト G protein coupled receptor and DNA sequence thereof
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
US20030211577A1 (en) * 2001-12-20 2003-11-13 Haifeng Eishingdrelo Novel G protein-coupled receptor, GAVE7
WO2003061365A2 (en) * 2002-01-23 2003-07-31 Aventis Pharmaceuticals Inc. A nucleic acid encoding a g-protein-coupled receptor, and uses thereof
US7527935B2 (en) 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
AU2003220913A1 (en) * 2002-03-19 2003-09-29 Tanabe Seiyaku Co., Ltd. Novel g protein-coupled recepotrs and genes thereof
US20080260744A1 (en) 2002-09-09 2008-10-23 Omeros Corporation G protein coupled receptors and uses thereof
US7524638B1 (en) 2003-06-27 2009-04-28 Osi Pharmaceuticals, Inc. Methods for identification of modulators of OSGPR114 or OSGPR78 activity, and their use in the treatment of disease
WO2006024449A2 (en) * 2004-09-01 2006-03-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with cysteinyl leukotriene receptor 1 (cyslt1)
WO2006040534A2 (en) * 2004-10-11 2006-04-20 Paradigm Therapeutics Limited Method of detecting the presence or activity of g - protein coupled receptor 92 (gpr92)
EP2091556B1 (en) * 2006-11-15 2018-07-25 Omeros Corporation Non-human animal comprising a mutation in the sreb2/gpr85 gene as animal model of metabolic disease

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892051A2 (en) * 1997-06-18 1999-01-20 Smithkline Beecham Corporation CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
WO1999046378A1 (en) * 1998-03-12 1999-09-16 Yamanouchi Pharmaceutical Co., Ltd. Novel g protein-coupled receptor proteins
WO1999055734A1 (en) * 1998-04-24 1999-11-04 Smithkline Beecham Corporation A g-protein coupled 7tm receptor (axor-1)
WO2000012707A1 (en) * 1998-09-02 2000-03-09 Millennium Pharmaceuticals, Inc. 14926 receptor, a novel g-protein coupled receptor
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000031258A2 (en) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Human orphan g protein-coupled receptors
WO2001007612A2 (en) * 1999-07-21 2001-02-01 Incyte Genomics, Inc. Receptors and associated proteins

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892051A2 (en) * 1997-06-18 1999-01-20 Smithkline Beecham Corporation CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
WO1999046378A1 (en) * 1998-03-12 1999-09-16 Yamanouchi Pharmaceutical Co., Ltd. Novel g protein-coupled receptor proteins
EP1067183A1 (en) * 1998-03-12 2001-01-10 Yamanouchi Pharmaceutical Co. Ltd. Novel g protein-coupled receptor proteins
WO1999055734A1 (en) * 1998-04-24 1999-11-04 Smithkline Beecham Corporation A g-protein coupled 7tm receptor (axor-1)
WO2000012707A1 (en) * 1998-09-02 2000-03-09 Millennium Pharmaceuticals, Inc. 14926 receptor, a novel g-protein coupled receptor
WO2000022131A2 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
WO2000031258A2 (en) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Human orphan g protein-coupled receptors
WO2001007612A2 (en) * 1999-07-21 2001-02-01 Incyte Genomics, Inc. Receptors and associated proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BULGER M. ET AL.: "Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 96, April 1999 (1999-04-01), pages 5129 - 5134, XP002169773 *
RAMING K. ET AL.: "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone", RECEPTORS AND CHANNELS, vol. 6, no. 2, 1998, pages 141 - 151, XP000925988 *
WATERSTONE R.H.: "The sequence of Homo sapiens clone; Homo sapiens chromosome 11 clone RP11_658K18, WORKING DRAFT SEQUENCE, 19 unordered pieces", EMBL DATABASE ENTRY AC026090; ACCESSION NO. AC026090, 20 March 2000 (2000-03-20), XP002169774 *

Also Published As

Publication number Publication date
CA2386509A1 (en) 2001-05-03
WO2001031014A2 (en) 2001-05-03
AU1575601A (en) 2001-05-08
EP1230361A2 (en) 2002-08-14

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