JP2005508610A5 - - Google Patents
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- Publication number
- JP2005508610A5 JP2005508610A5 JP2002592486A JP2002592486A JP2005508610A5 JP 2005508610 A5 JP2005508610 A5 JP 2005508610A5 JP 2002592486 A JP2002592486 A JP 2002592486A JP 2002592486 A JP2002592486 A JP 2002592486A JP 2005508610 A5 JP2005508610 A5 JP 2005508610A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- rna
- molecule according
- dna molecule
- heterologous protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 claims 57
- 102000004169 proteins and genes Human genes 0.000 claims 57
- 108020004414 DNA Proteins 0.000 claims 29
- 102000053602 DNA Human genes 0.000 claims 26
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 20
- 239000012634 fragment Substances 0.000 claims 16
- 241001493065 dsRNA viruses Species 0.000 claims 12
- 108091092258 Cis-acting replication element Proteins 0.000 claims 8
- 206010022000 influenza Diseases 0.000 claims 8
- 244000052769 pathogen Species 0.000 claims 8
- 230000001717 pathogenic effect Effects 0.000 claims 8
- 230000003612 virological effect Effects 0.000 claims 8
- 229960005486 vaccine Drugs 0.000 claims 7
- 102000011931 Nucleoproteins Human genes 0.000 claims 5
- 108010061100 Nucleoproteins Proteins 0.000 claims 5
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 5
- 101710154606 Hemagglutinin Proteins 0.000 claims 4
- 241000710185 Mengo virus Species 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 4
- 101710176177 Protein A56 Proteins 0.000 claims 4
- 101150093578 VP2 gene Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000000975 bioactive effect Effects 0.000 claims 4
- 239000000185 hemagglutinin Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 230000029812 viral genome replication Effects 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 3
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 239000003145 cytotoxic factor Substances 0.000 claims 3
- 239000005090 green fluorescent protein Substances 0.000 claims 3
- 241000710190 Cardiovirus Species 0.000 claims 2
- 241001180873 Saposhnikovia divaricata Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 206010008761 Choriomeningitis lymphocytic Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 108091061960 Naked DNA Proteins 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000010775 animal oil Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 208000001419 lymphocytic choriomeningitis Diseases 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- 239000003208 petroleum Substances 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29251501P | 2001-05-23 | 2001-05-23 | |
| PCT/IB2002/002810 WO2002095023A2 (en) | 2001-05-23 | 2002-05-23 | Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508610A JP2005508610A (ja) | 2005-04-07 |
| JP2005508610A5 true JP2005508610A5 (https=) | 2006-01-05 |
Family
ID=23124993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592486A Withdrawn JP2005508610A (ja) | 2001-05-23 | 2002-05-23 | 異種タンパク質の製造に有用なプラス鎖ｒｎａウイルスゲノムに由来するレプリコン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20030077251A1 (https=) |
| EP (1) | EP1390517A2 (https=) |
| JP (1) | JP2005508610A (https=) |
| KR (1) | KR20040007567A (https=) |
| CN (1) | CN1575339A (https=) |
| AU (1) | AU2002339603A1 (https=) |
| CA (1) | CA2443258A1 (https=) |
| WO (1) | WO2002095023A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060017635A (ko) | 2003-06-05 | 2006-02-24 | 와이어쓰 홀딩스 코포레이션 | 베네쥬엘라 말 뇌염 바이러스 레플리콘 벡터 및파라믹소바이러스 단백질 항원을 포함하는 면역원성 조성물 |
| KR100788894B1 (ko) | 2005-12-09 | 2007-12-27 | 한국전자통신연구원 | 확대된 서비스 영역을 제공하는 직교 주파수 분할 다중방식의 무선 랜 송수신 시스템 및 그 방법 |
| US20100111873A1 (en) * | 2007-02-20 | 2010-05-06 | Russell Stephen J | Treating cancer with viral nucleic acid |
| CA2689108C (en) * | 2007-06-01 | 2015-04-14 | Universidad De Barcelona | Control for virus detection assays based on reverse-transcription polymerase chain reaction |
| EP2130912A1 (en) * | 2008-06-04 | 2009-12-09 | Institut für Viruskrankeiten und Immunprophylaxe | Pestivirus replicons providing an RNA-based viral vector system |
| KR101694559B1 (ko) * | 2008-09-24 | 2017-01-09 | 가부시키가이샤 리보믹 | Ｎｇｆ에 대한 압타머 및 이의 용도 |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| EP2591114B1 (en) | 2010-07-06 | 2016-06-08 | GlaxoSmithKline Biologicals SA | Immunisation of large mammals with low doses of rna |
| MX342608B (es) | 2010-07-06 | 2016-10-06 | Novartis Ag * | Particulas de suministro similares a viriones para moleculas de arn de autorreplicacion. |
| ES2557382T3 (es) | 2010-07-06 | 2016-01-25 | Glaxosmithkline Biologicals Sa | Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN |
| ES2646669T3 (es) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN |
| LT4226941T (lt) | 2010-08-31 | 2025-01-10 | Glaxosmithkline Biologicals Sa | Pegilintos liposomos, skirtos imunogeną koduojančios rnr pristatymui |
| SI4043040T1 (sl) | 2010-08-31 | 2023-04-28 | Glaxosmithkline Biologicals Sa | Mali liposomi za dostavo imunogen-kodirajoče RNA |
| WO2012051211A2 (en) | 2010-10-11 | 2012-04-19 | Novartis Ag | Antigen delivery platforms |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| ES2795110T3 (es) | 2011-06-08 | 2020-11-20 | Translate Bio Inc | Lípidos escindibles |
| EP4115875A1 (en) * | 2011-07-06 | 2023-01-11 | GlaxoSmithKline Biologicals S.A. | Liposomes having useful n:p ratio for delivery of rna molecules |
| EP2729165B1 (en) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| CA3180557A1 (en) * | 2020-05-29 | 2021-12-02 | Lorena Lerner | Encapsulated rna replicons and methods of use |
| CN114231562A (zh) * | 2021-12-15 | 2022-03-25 | 中国科学院武汉病毒研究所 | 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用 |
| CN114317563B (zh) * | 2021-12-17 | 2023-09-05 | 华南理工大学 | 提高基因表达的rna复制子及其应用 |
| WO2023221938A1 (zh) * | 2022-05-16 | 2023-11-23 | 上海行深生物科技有限公司 | 蛋白包裹自复制rna及其制备方法 |
| EP4703471A1 (en) * | 2023-04-25 | 2026-03-04 | Shinshu University | Method for controlling transcription and/or replication of vrna by influenza virus rdrp, and use of same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125896D0 (en) * | 1991-12-05 | 1992-02-05 | Almond Jeffrey W | Bicistronic viruses |
| EP0702724A1 (en) * | 1993-06-03 | 1996-03-27 | Institut Pasteur | Mengovirus as a vector for expression of foreign polypeptides |
| US5811407A (en) * | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
-
2002
- 2002-05-22 US US10/152,040 patent/US20030077251A1/en not_active Abandoned
- 2002-05-23 CN CNA028104889A patent/CN1575339A/zh active Pending
- 2002-05-23 JP JP2002592486A patent/JP2005508610A/ja not_active Withdrawn
- 2002-05-23 US US10/478,434 patent/US20050118566A1/en not_active Abandoned
- 2002-05-23 CA CA002443258A patent/CA2443258A1/en not_active Abandoned
- 2002-05-23 AU AU2002339603A patent/AU2002339603A1/en not_active Abandoned
- 2002-05-23 WO PCT/IB2002/002810 patent/WO2002095023A2/en not_active Ceased
- 2002-05-23 KR KR10-2003-7014871A patent/KR20040007567A/ko not_active Withdrawn
- 2002-05-23 EP EP02743559A patent/EP1390517A2/en not_active Withdrawn
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