JP2005508306A5 - - Google Patents

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Publication number
JP2005508306A5
JP2005508306A5 JP2003515539A JP2003515539A JP2005508306A5 JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5 JP 2003515539 A JP2003515539 A JP 2003515539A JP 2003515539 A JP2003515539 A JP 2003515539A JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5
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embryo
mammal
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immature body
immature
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JP2003515539A
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JP2005508306A (ja
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Priority claimed from PCT/US2002/022869 external-priority patent/WO2003010180A1/en
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JP2003515539A 2001-07-23 2002-07-19 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物 Withdrawn JP2005508306A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30741101P 2001-07-23 2001-07-23
US36066402P 2002-02-27 2002-02-27
PCT/US2002/022869 WO2003010180A1 (en) 2001-07-23 2002-07-19 Methods and compositions for rnai mediated inhibition of gene expression in mammals

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2010249697A Division JP6055164B2 (ja) 2001-07-23 2010-11-08 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2014187281A Division JP2015044809A (ja) 2001-07-23 2014-09-16 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物

Publications (2)

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JP2005508306A JP2005508306A (ja) 2005-03-31
JP2005508306A5 true JP2005508306A5 (enExample) 2006-01-05

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JP2003515539A Withdrawn JP2005508306A (ja) 2001-07-23 2002-07-19 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2010249697A Expired - Lifetime JP6055164B2 (ja) 2001-07-23 2010-11-08 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2014187281A Pending JP2015044809A (ja) 2001-07-23 2014-09-16 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2016159918A Expired - Lifetime JP6247355B2 (ja) 2001-07-23 2016-08-17 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物

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JP2010249697A Expired - Lifetime JP6055164B2 (ja) 2001-07-23 2010-11-08 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2014187281A Pending JP2015044809A (ja) 2001-07-23 2014-09-16 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物
JP2016159918A Expired - Lifetime JP6247355B2 (ja) 2001-07-23 2016-08-17 哺乳類における遺伝子発現のＲＮＡｉによる阻害に関する方法および組成物

Country Status (9)

Country Link
US (3) US20030153519A1 (enExample)
EP (2) EP2280070B1 (enExample)
JP (4) JP2005508306A (enExample)
AT (1) ATE556720T1 (enExample)
CA (2) CA2936534C (enExample)
DK (2) DK1409506T3 (enExample)
ES (2) ES2386775T3 (enExample)
PT (1) PT2280070E (enExample)
WO (1) WO2003010180A1 (enExample)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143204A1 (en) * 2001-07-27 2003-07-31 Lewis David L. Inhibition of RNA function by delivery of inhibitors to animal cells
US20050222075A1 (en) * 1998-09-14 2005-10-06 Hans Herweijer Process for delivering nucleic acids to cardiac tissue
IL145778A0 (en) * 1999-04-21 2002-07-25 American Home Prod Methods and compositions for inhibiting the function of polynucleotide sequences
US20040138168A1 (en) * 1999-04-21 2004-07-15 Wyeth Methods and compositions for inhibiting the function of polynucleotide sequences
AU2001245793A1 (en) 2000-03-16 2001-09-24 Cold Spring Harbor Laboratory Methods and compositions for rna interference
US8202846B2 (en) 2000-03-16 2012-06-19 Cold Spring Harbor Laboratory Methods and compositions for RNA interference
ES2386775T3 (es) 2001-07-23 2012-08-30 The Board Of Trustees Of The Leland Stanford Junior University Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos
US10590418B2 (en) * 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
US7101995B2 (en) * 2001-08-27 2006-09-05 Mirus Bio Corporation Compositions and processes using siRNA, amphipathic compounds and polycations
DE60218710T2 (de) 2001-09-25 2007-12-06 Oncotherapy Science, Inc., Kawasaki Gen und protein mit bezug zu hepatozellulärem karzinom
EP1478656B1 (en) 2002-02-01 2009-09-16 Life Technologies Corporation Oligonucleotide compositions with enhanced efficiency
WO2003064621A2 (en) 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US8202845B2 (en) * 2002-04-18 2012-06-19 Acuity Pharmaceuticals, Inc. Means and methods for the specific modulation of target genes in the CNS and the eye and methods for their identification
US20030228691A1 (en) * 2002-05-17 2003-12-11 Lewis David L. Processes for inhibiting gene expression using polynucleotides
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
DE60326961D1 (de) 2002-07-26 2009-05-14 Novartis Vaccines & Diagnostic Modifizierte kleine irns moleküle und methoden zu deren anwendung
US20050042646A1 (en) 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7781415B2 (en) * 2003-02-07 2010-08-24 Roche Madison Inc. Process for delivering sirna to cardiac muscle tissue
DE602004032114D1 (de) * 2003-02-28 2011-05-19 Oncotherapy Science Inc Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen
SI1897548T2 (sl) * 2003-02-28 2024-09-30 The Johns Hopkins University Regulacija celic T
US7750144B2 (en) * 2003-06-02 2010-07-06 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNA silencing
JP5666074B2 (ja) * 2003-06-06 2015-02-12 セネスコ テクノロジーズ，インコーポレイティド 抗炎症療法としての、アンチセンス・オリゴヌクレオチドとｓｉＲＮＡを用いてアポトーシス特異的ｅＩＦ−５Ａ（“ｅＩＦ−５Ａ”）の阻害
WO2005026322A2 (en) * 2003-09-11 2005-03-24 Clontech Laboratories, Inc. siRNA ENCODING CONSTRUCTS AND METHODS FOR USING THE SAME
TWI350373B (en) 2004-01-23 2011-10-11 Oncotherapy Science Inc Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators
EP1737956A2 (en) * 2004-03-01 2007-01-03 Massachusetts Institute of Technology Rnai-based therapeutics for allergic rhinitis and asthma
US20050233994A1 (en) * 2004-04-16 2005-10-20 Ajamete Kaykas Methods and vectors for expressing siRNA
WO2005118640A2 (en) 2004-04-20 2005-12-15 University Of Utah Research Foundation A h+-gated ion channel
WO2005125179A1 (ja) * 2004-06-22 2005-12-29 Nikon Corporation 質感を強調する画像処理装置、画像処理プログラム、電子カメラ、および画像処理方法
US20060063208A1 (en) 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
CA2576576A1 (en) * 2004-08-11 2006-02-16 Receptor Biologix, Inc. Gastrin-specific interfering rna
US20090170794A1 (en) * 2004-09-10 2009-07-02 Somagenics Inc. Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
US8765704B1 (en) 2008-02-28 2014-07-01 Novartis Ag Modified small interfering RNA molecules and methods of use
EP1796732B1 (en) * 2004-10-01 2013-10-30 Novartis Vaccines and Diagnostics, Inc. Modified small interfering rna molecules and methods of use
US7790693B2 (en) * 2004-12-02 2010-09-07 University Of Massachusetts Glucose-transport related genes, polypeptides, and methods of use thereof
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
JP2008526213A (ja) * 2004-12-30 2008-07-24 トッド エム． ハウザー， 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法
CN101111269A (zh) * 2005-01-28 2008-01-23 协和发酵工业株式会社 抑制靶基因表达的组合物
EP1866436A1 (en) 2005-02-28 2007-12-19 Oncotherapy Science, Inc. Breast cancer related gene znfn3a1
EP1714970A1 (en) * 2005-04-22 2006-10-25 Universität des Saarlandes Use of inhibitors of RNAse A-family enzymes for stabilizing oligonucleotides having RNA interfering activity
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
US7919583B2 (en) * 2005-08-08 2011-04-05 Discovery Genomics, Inc. Integration-site directed vector systems
US7723314B1 (en) 2005-10-28 2010-05-25 Transderm, Inc. Methods and compositions for treating pachyonychia congenita
JPWO2007080902A1 (ja) 2006-01-11 2009-06-11 協和発酵キリン株式会社 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤
EP1979485A2 (en) 2006-01-31 2008-10-15 The Board Of Trustees Of The Leland Stanford Junior University Self-complementary parvoviral vectors, and methods for making and using the same
JP4752912B2 (ja) * 2006-02-27 2011-08-17 株式会社ニコン 画像の質感を補正する画像処理装置、画像処理プログラム、画像処理方法、および電子カメラ
GB0608838D0 (en) 2006-05-04 2006-06-14 Novartis Ag Organic compounds
EP2236623A1 (en) 2006-06-05 2010-10-06 Cancer Care Ontario Assessment of risk for colorectal cancer
EP2383341A1 (en) * 2006-06-12 2011-11-02 Exegenics, Inc., D/b/a Opko Health, Inc. Compositions and methods for siRNA inhibition of angiogenesis
US7872118B2 (en) * 2006-09-08 2011-01-18 Opko Ophthalmics, Llc siRNA and methods of manufacture
CA2679954A1 (en) 2007-03-05 2008-09-12 Cancer Care Ontario Assessment of risk for colorectal cancer
JP5272134B2 (ja) 2007-06-14 2013-08-28 オンコセラピー・サイエンス株式会社 Ｓｍｙｄ３によるｖｅｇｆｒ１のメチル化調整因子を同定する方法
EP2170395A1 (en) * 2007-07-02 2010-04-07 Wyeth LLC Modulators of axl for use in treating bone disorders
US8309791B2 (en) 2008-07-16 2012-11-13 Recombinectics, Inc. Method for producing a transgenic pig using a hyper-methylated transposon
CN105030809A (zh) 2008-08-01 2015-11-11 协和发酵麒麟株式会社 抑制靶基因表达的组合物
AU2009322279A1 (en) 2008-12-04 2011-07-14 Opko Pharmaceuticals, Llc Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms
CA2764158A1 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
EP2454371B1 (en) 2009-07-13 2021-01-20 Somagenics, Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
WO2016187217A2 (en) 2015-05-18 2016-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
JP5952197B2 (ja) 2011-01-19 2016-07-13 協和発酵キリン株式会社 標的遺伝子の発現を抑制する組成物
ES2741282T3 (es) 2011-05-05 2020-02-10 Matinas Biopharma Nanotechnologies Inc Composiciones de cocleato y métodos de elaboración y uso de las mismas
WO2014013995A1 (ja) 2012-07-16 2014-01-23 協和発酵キリン株式会社 KRAS遺伝子発現抑制RNAi医薬組成物
AU2013308519A1 (en) * 2012-08-31 2015-04-09 The General Hospital Corporation Biotin complexes for treatment and diagnosis of Alzheimer's disease
CN104342453A (zh) 2013-08-06 2015-02-11 深圳先进技术研究院 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用
US9545417B2 (en) 2014-05-01 2017-01-17 The Johns Hopkins University Methods of inhibiting cancer stem cells with HMGA1 inhibitors
EP3160479A4 (en) * 2014-06-30 2018-07-04 Academia Sinica Antagonists for interleukin-17 receptor b (il-17rb) and its ligand il-17b for cancer therapy
WO2016022947A1 (en) 2014-08-07 2016-02-11 The Johns Hopkins University Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases
US10265372B2 (en) 2014-08-12 2019-04-23 The Regents Of The University Of California Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues
EP3188746B1 (en) 2014-09-05 2024-06-19 The Johns Hopkins University Targeting capn9 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
CA2995995A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도
WO2022076812A2 (en) 2020-10-09 2022-04-14 University Of Massachusetts Targeting nrip1 to alleviate metabolic disease

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3250802B2 (ja) 1989-03-21 2002-01-28 バイカル・インコーポレイテッド 脊椎動物における外因性ポリヌクレオチド配列の発現
US5610050A (en) * 1990-04-20 1997-03-11 The General Hospital Corporation Methods of preventing viral replication
US6344321B1 (en) 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
CA2038839A1 (en) * 1991-03-22 1992-09-23 Jiang J. Liu Method for detection of viral rna
ES2040615B1 (es) * 1991-05-27 1994-05-16 Nebrda Fernando Javi Bartolome Procedimiento para el aislamiento y clonaje de cdnas derivados del virus c de la hepatitis.
US6030954A (en) * 1991-09-05 2000-02-29 University Of Connecticut Targeted delivery of poly- or oligonucleotides to cells
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US6174868B1 (en) * 1992-09-10 2001-01-16 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
WO1994018156A1 (en) * 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
US5985847A (en) 1993-08-26 1999-11-16 The Regents Of The University Of California Devices for administration of naked polynucleotides which encode biologically active peptides
US5712384A (en) * 1994-01-05 1998-01-27 Gene Shears Pty Ltd. Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs
WO1995030746A1 (en) * 1994-05-10 1995-11-16 The General Hospital Corporation Antisense inhibition of hepatitis c virus
US6107027A (en) * 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
US5922687A (en) * 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US5981279A (en) * 1995-11-09 1999-11-09 Allegheny University Of The Health Sciences Compositions and methods to regulate calmodulin gene expression, and uses thereof for influencing cell growth and differentiation
JP4033502B2 (ja) 1996-02-08 2008-01-16 アンジェスＭｇ株式会社 リボザイム、リポソーム製剤及びその用途
CA2250923A1 (en) * 1996-03-26 1997-10-02 Gabriella Zupi Oligonucleotide treatments and compositions for human melanoma
US6210707B1 (en) 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
CA2284922A1 (en) 1997-04-04 1998-10-15 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
US5948902A (en) 1997-11-20 1999-09-07 South Alabama Medical Science Foundation Antisense oligonucleotides to human serine/threonine protein phosphatase genes
US5957978A (en) 1997-12-22 1999-09-28 Hansa Medical Products, Inc. Valved fenestrated tracheotomy tube
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) * 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
ES2374534T3 (es) 1998-03-20 2012-02-17 Commonwealth Scientific And Industrial Research Organisation Control de la expresión de genes.
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
IL145778A0 (en) * 1999-04-21 2002-07-25 American Home Prod Methods and compositions for inhibiting the function of polynucleotide sequences
GB9925459D0 (en) * 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
ATE342736T1 (de) 1999-11-05 2006-11-15 Mirus Bio Corp Intravaskuläre verabreichung von nukleinsäuren
GB9927444D0 (en) * 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
DE10160151A1 (de) 2001-01-09 2003-06-26 Ribopharma Ag Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US20030084471A1 (en) 2000-03-16 2003-05-01 David Beach Methods and compositions for RNA interference
AU2001245793A1 (en) 2000-03-16 2001-09-24 Cold Spring Harbor Laboratory Methods and compositions for rna interference
CN1426466A (zh) 2000-03-17 2003-06-25 贝尼泰克澳大利亚有限公司 遗传沉默
CA2404890C (en) 2000-03-30 2013-11-19 Whitehead Institute For Biomedical Research Rna sequence-specific mediators of rna interference
US20020132788A1 (en) * 2000-11-06 2002-09-19 David Lewis Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo
CZ302719B6 (cs) 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
DE10100588A1 (de) 2001-01-09 2002-07-18 Ribopharma Ag Verfahren zur Hemmung der Expression eines Zielgens
WO2002097114A2 (en) * 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
US7000102B2 (en) 2001-06-29 2006-02-14 Intel Corporation Platform and method for supporting hibernate operations
KR20040022449A (ko) 2001-07-12 2004-03-12 유니버시티 오브 매사추세츠 유전자 불활성화를 매개하는 소형 간섭 ｒｎａ의 생체내제조
ES2386775T3 (es) 2001-07-23 2012-08-30 The Board Of Trustees Of The Leland Stanford Junior University Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos
EP1430157B1 (en) 2002-02-20 2011-08-10 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

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