JP2005508306A5 - - Google Patents
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- Publication number
- JP2005508306A5 JP2005508306A5 JP2003515539A JP2003515539A JP2005508306A5 JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5 JP 2003515539 A JP2003515539 A JP 2003515539A JP 2003515539 A JP2003515539 A JP 2003515539A JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5
- Authority
- JP
- Japan
- Prior art keywords
- embryo
- mammal
- adult
- immature body
- immature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000124008 Mammalia Species 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30741101P | 2001-07-23 | 2001-07-23 | |
| US36066402P | 2002-02-27 | 2002-02-27 | |
| PCT/US2002/022869 WO2003010180A1 (en) | 2001-07-23 | 2002-07-19 | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Division JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Division JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508306A JP2005508306A (ja) | 2005-03-31 |
| JP2005508306A5 true JP2005508306A5 (enExample) | 2006-01-05 |
Family
ID=26975733
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515539A Withdrawn JP2005508306A (ja) | 2001-07-23 | 2002-07-19 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20030153519A1 (enExample) |
| EP (2) | EP2280070B1 (enExample) |
| JP (4) | JP2005508306A (enExample) |
| AT (1) | ATE556720T1 (enExample) |
| CA (2) | CA2936534C (enExample) |
| DK (2) | DK1409506T3 (enExample) |
| ES (2) | ES2386775T3 (enExample) |
| PT (1) | PT2280070E (enExample) |
| WO (1) | WO2003010180A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030143204A1 (en) * | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
| US20050222075A1 (en) * | 1998-09-14 | 2005-10-06 | Hans Herweijer | Process for delivering nucleic acids to cardiac tissue |
| US20040138168A1 (en) * | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
| CA2370628A1 (en) * | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| WO2001068836A2 (en) | 2000-03-16 | 2001-09-20 | Genetica, Inc. | Methods and compositions for rna interference |
| US8202846B2 (en) | 2000-03-16 | 2012-06-19 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| ES2386775T3 (es) | 2001-07-23 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos |
| US7101995B2 (en) * | 2001-08-27 | 2006-09-05 | Mirus Bio Corporation | Compositions and processes using siRNA, amphipathic compounds and polycations |
| ATE356223T1 (de) | 2001-09-25 | 2007-03-15 | Japan President Univ Tokyo | Gen und protein mit bezug zu hepatozellulärem karzinom |
| WO2003064621A2 (en) | 2002-02-01 | 2003-08-07 | Ambion, Inc. | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| EP3415625A1 (en) | 2002-02-01 | 2018-12-19 | Life Technologies Corporation | Double-stranded oligonucleotides |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| JP5578388B2 (ja) * | 2002-04-18 | 2014-08-27 | オプコ ファーマシューティカルズ、エルエルシー | 中枢神経システム及び/若しくは眼の細胞及び組織中の遺伝子の特異的阻害のための手段と方法 |
| US20030228691A1 (en) * | 2002-05-17 | 2003-12-11 | Lewis David L. | Processes for inhibiting gene expression using polynucleotides |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| EP1532248B1 (en) * | 2002-07-26 | 2009-04-01 | Novartis Vaccines and Diagnostics, Inc. | Modified small interfering rna molecules and methods of use |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| EP2112229A3 (en) | 2002-11-25 | 2009-12-02 | Sequenom, Inc. | Methods for identifying risk of breast cancer and treatments thereof |
| US7781415B2 (en) * | 2003-02-07 | 2010-08-24 | Roche Madison Inc. | Process for delivering sirna to cardiac muscle tissue |
| CN102172408A (zh) * | 2003-02-28 | 2011-09-07 | 肿瘤疗法科学股份有限公司 | 抑制细胞生长的组合物和方法 |
| US20060240024A1 (en) * | 2003-02-28 | 2006-10-26 | The Johns Hopkins University | T cell regulation |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| NZ544159A (en) * | 2003-06-06 | 2009-04-30 | Senesco Technologies Inc | Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics |
| US20050060771A1 (en) * | 2003-09-11 | 2005-03-17 | Farmer Andrew Alan | siRNA encoding constructs and methods for using the same |
| TWI350373B (en) | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| US20060058255A1 (en) * | 2004-03-01 | 2006-03-16 | Jianzhu Chen | RNAi-based therapeutics for allergic rhinitis and asthma |
| US20050233994A1 (en) * | 2004-04-16 | 2005-10-20 | Ajamete Kaykas | Methods and vectors for expressing siRNA |
| WO2005118640A2 (en) | 2004-04-20 | 2005-12-15 | University Of Utah Research Foundation | A h+-gated ion channel |
| JP4595939B2 (ja) * | 2004-06-22 | 2010-12-08 | 株式会社ニコン | 質感を強調する画像処理装置、画像処理プログラム、電子カメラ、および画像処理方法 |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| AU2005270917A1 (en) * | 2004-08-11 | 2006-02-16 | Cancer Advances, Inc. | Gastrin-specific interfering RNA |
| US20090170794A1 (en) | 2004-09-10 | 2009-07-02 | Somagenics Inc. | Small interfering rnas that efficiently inhibit viral expression and methods of use thereof |
| US8765704B1 (en) | 2008-02-28 | 2014-07-01 | Novartis Ag | Modified small interfering RNA molecules and methods of use |
| EP1796732B1 (en) * | 2004-10-01 | 2013-10-30 | Novartis Vaccines and Diagnostics, Inc. | Modified small interfering rna molecules and methods of use |
| CA2589902A1 (en) * | 2004-12-02 | 2006-06-08 | University Of Massachusetts | Glucose-transport related genes, polypeptides, and methods of use thereof |
| US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| MX2007008065A (es) * | 2004-12-30 | 2008-03-04 | Todd M Hauser | Composiciones y metodos para modular la expresion genica usando oligonucleotidos autoprotegidos. |
| AU2005326371A1 (en) * | 2005-01-28 | 2006-08-03 | Kyowa Hakko Kirin Co., Ltd. | Composition for inhibiting expression of target gene |
| WO2006092958A1 (en) | 2005-02-28 | 2006-09-08 | Oncotherapy Science, Inc. | Breast cancer related gene znfn3a1 |
| EP1714970A1 (en) * | 2005-04-22 | 2006-10-25 | Universität des Saarlandes | Use of inhibitors of RNAse A-family enzymes for stabilizing oligonucleotides having RNA interfering activity |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| US7919583B2 (en) * | 2005-08-08 | 2011-04-05 | Discovery Genomics, Inc. | Integration-site directed vector systems |
| US7723314B1 (en) | 2005-10-28 | 2010-05-25 | Transderm, Inc. | Methods and compositions for treating pachyonychia congenita |
| WO2007080902A1 (ja) | 2006-01-11 | 2007-07-19 | Kyowa Hakko Kogyo Co., Ltd. | 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤 |
| WO2008016391A2 (en) * | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| WO2007097125A1 (ja) * | 2006-02-27 | 2007-08-30 | Nikon Corporation | 画像の質感を補正する画像処理装置、画像処理プログラム、画像処理方法、および電子カメラ |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| WO2007140599A1 (en) | 2006-06-05 | 2007-12-13 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| JP2009540011A (ja) * | 2006-06-12 | 2009-11-19 | エクセジェニックス、インク.ディー/ビー/エー オプコ ヘルス、インク. | 血管新生のsiRNA阻害のための組成物及び方法 |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| US20110189663A1 (en) | 2007-03-05 | 2011-08-04 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| WO2008152816A1 (en) | 2007-06-14 | 2008-12-18 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
| WO2009005813A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| US8309791B2 (en) * | 2008-07-16 | 2012-11-13 | Recombinectics, Inc. | Method for producing a transgenic pig using a hyper-methylated transposon |
| WO2010013815A1 (ja) | 2008-08-01 | 2010-02-04 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| US8470792B2 (en) | 2008-12-04 | 2013-06-25 | Opko Pharmaceuticals, Llc. | Compositions and methods for selective inhibition of VEGF |
| CA2764158A1 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| JP5952197B2 (ja) | 2011-01-19 | 2016-07-13 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| CA2834788C (en) | 2011-05-05 | 2020-11-17 | Coordinated Program Development, Llc | Cochleate compositions and methods of making and using same |
| US9913907B2 (en) | 2012-07-16 | 2018-03-13 | Kyowa Hakko Kirin Co., Ltd. | RNAi pharmaceutical composition for suppressing expression of KRAS gene |
| CA2883130A1 (en) * | 2012-08-31 | 2014-03-06 | The General Hospital Corporation | Biotin complexes for treatment and diagnosis of alzheimer's disease |
| CN104342453A (zh) | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
| US9545417B2 (en) | 2014-05-01 | 2017-01-17 | The Johns Hopkins University | Methods of inhibiting cancer stem cells with HMGA1 inhibitors |
| CN106794194A (zh) * | 2014-06-30 | 2017-05-31 | 中央研究院 | 用于癌症治疗的介白素‑17受体b(il‑17rb)及其配体il‑17b之拮抗剂 |
| WO2016022947A1 (en) | 2014-08-07 | 2016-02-11 | The Johns Hopkins University | Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases |
| WO2016025629A1 (en) | 2014-08-12 | 2016-02-18 | The Regents Of The University Of California | Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues |
| US11219670B2 (en) | 2014-09-05 | 2022-01-11 | The Johns Hopkins University | Targeting CAPN9/CAPNS2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies |
| CN107921188A (zh) | 2015-05-18 | 2018-04-17 | 小利兰·斯坦福大学托管委员会 | 用于治疗衰老相关的损伤的方法和组合物 |
| WO2017035278A1 (en) | 2015-08-24 | 2017-03-02 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotide nanoparticles for the modulation of gene expression and uses thereof |
| EP3481835A4 (en) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | CALPAIN MODULATORS AND THERAPEUTIC USE THEREOF |
| SG10201912574WA (en) | 2016-09-28 | 2020-02-27 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
| EP4225904A4 (en) | 2020-10-09 | 2025-10-08 | Univ Massachusetts | TARGETING NRIP1 TO ALLEVIATE METABOLIC DISEASE |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0737750B1 (en) | 1989-03-21 | 2003-05-14 | Vical, Inc. | Expression of exogenous polynucleotide sequences in a vertebrate |
| US5610050A (en) * | 1990-04-20 | 1997-03-11 | The General Hospital Corporation | Methods of preventing viral replication |
| US6344321B1 (en) | 1990-06-11 | 2002-02-05 | Gilead Sciences, Inc. | Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met |
| CA2038839A1 (en) * | 1991-03-22 | 1992-09-23 | Jiang J. Liu | Method for detection of viral rna |
| ES2040615B1 (es) * | 1991-05-27 | 1994-05-16 | Nebrda Fernando Javi Bartolome | Procedimiento para el aislamiento y clonaje de cdnas derivados del virus c de la hepatitis. |
| US6030954A (en) * | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| AU6230594A (en) * | 1993-02-01 | 1994-08-29 | University Of Iowa Research Foundation, The | Quartenary amine surfactants and methods of using same in isolation of rna |
| US5985847A (en) * | 1993-08-26 | 1999-11-16 | The Regents Of The University Of California | Devices for administration of naked polynucleotides which encode biologically active peptides |
| US5712384A (en) * | 1994-01-05 | 1998-01-27 | Gene Shears Pty Ltd. | Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
| JPH10503364A (ja) * | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | C型肝炎ウイルスのアンチセンス阻害 |
| US6107027A (en) * | 1994-12-14 | 2000-08-22 | University Of Washington | Ribozymes for treating hepatitis C |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| US5981279A (en) * | 1995-11-09 | 1999-11-09 | Allegheny University Of The Health Sciences | Compositions and methods to regulate calmodulin gene expression, and uses thereof for influencing cell growth and differentiation |
| JP4033502B2 (ja) | 1996-02-08 | 2008-01-16 | アンジェスMg株式会社 | リボザイム、リポソーム製剤及びその用途 |
| EP0932698A1 (en) * | 1996-03-26 | 1999-08-04 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
| US6210707B1 (en) | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
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| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| BRPI9908967B1 (pt) | 1998-03-20 | 2017-05-30 | Benitec Australia Ltd | processos para reprimir, retardar ou de outro modo reduzir a expressão de um gene alvo em uma célula de planta |
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| WO2001068836A2 (en) | 2000-03-16 | 2001-09-20 | Genetica, Inc. | Methods and compositions for rna interference |
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| US20020132788A1 (en) * | 2000-11-06 | 2002-09-19 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
| KR100872437B1 (ko) * | 2000-12-01 | 2008-12-05 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
| DE10100588A1 (de) | 2001-01-09 | 2002-07-18 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Zielgens |
| US20030124513A1 (en) * | 2001-05-29 | 2003-07-03 | Mcswiggen James | Enzymatic nucleic acid treatment of diseases or conditions related to levels of HIV |
| US7000102B2 (en) | 2001-06-29 | 2006-02-14 | Intel Corporation | Platform and method for supporting hibernate operations |
| ES2609014T3 (es) | 2001-07-12 | 2017-04-18 | University Of Massachusetts | Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico |
| ES2386775T3 (es) | 2001-07-23 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos |
| GB2397062B (en) | 2002-02-20 | 2005-06-15 | Sirna Therapeutics Inc | RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA) |
-
2002
- 2002-07-19 ES ES02761123T patent/ES2386775T3/es not_active Expired - Lifetime
- 2002-07-19 EP EP10178509.5A patent/EP2280070B1/en not_active Expired - Lifetime
- 2002-07-19 CA CA2936534A patent/CA2936534C/en not_active Expired - Lifetime
- 2002-07-19 DK DK02761123.5T patent/DK1409506T3/da active
- 2002-07-19 US US10/200,002 patent/US20030153519A1/en not_active Abandoned
- 2002-07-19 AT AT02761123T patent/ATE556720T1/de active
- 2002-07-19 WO PCT/US2002/022869 patent/WO2003010180A1/en not_active Ceased
- 2002-07-19 DK DK10178509.5T patent/DK2280070T3/en active
- 2002-07-19 EP EP02761123A patent/EP1409506B1/en not_active Expired - Lifetime
- 2002-07-19 PT PT101785095T patent/PT2280070E/pt unknown
- 2002-07-19 ES ES10178509.5T patent/ES2546829T3/es not_active Expired - Lifetime
- 2002-07-19 JP JP2003515539A patent/JP2005508306A/ja not_active Withdrawn
- 2002-07-19 CA CA2454183A patent/CA2454183C/en not_active Expired - Lifetime
-
2010
- 2010-11-08 JP JP2010249697A patent/JP6055164B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-12 US US13/941,262 patent/US10517887B2/en not_active Expired - Fee Related
-
2014
- 2014-09-16 JP JP2014187281A patent/JP2015044809A/ja active Pending
-
2016
- 2016-08-17 JP JP2016159918A patent/JP6247355B2/ja not_active Expired - Lifetime
-
2019
- 2019-12-20 US US16/723,744 patent/US20200246370A1/en not_active Abandoned
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