JP2005508306A5 - - Google Patents
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- JP2005508306A5 JP2005508306A5 JP2003515539A JP2003515539A JP2005508306A5 JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5 JP 2003515539 A JP2003515539 A JP 2003515539A JP 2003515539 A JP2003515539 A JP 2003515539A JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5
- Authority
- JP
- Japan
- Prior art keywords
- embryo
- mammal
- adult
- immature body
- immature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 241000124008 Mammalia Species 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30741101P | 2001-07-23 | 2001-07-23 | |
| US36066402P | 2002-02-27 | 2002-02-27 | |
| PCT/US2002/022869 WO2003010180A1 (en) | 2001-07-23 | 2002-07-19 | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Division JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Division JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508306A JP2005508306A (ja) | 2005-03-31 |
| JP2005508306A5 true JP2005508306A5 (enExample) | 2006-01-05 |
Family
ID=26975733
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515539A Withdrawn JP2005508306A (ja) | 2001-07-23 | 2002-07-19 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20030153519A1 (enExample) |
| EP (2) | EP1409506B1 (enExample) |
| JP (4) | JP2005508306A (enExample) |
| AT (1) | ATE556720T1 (enExample) |
| CA (2) | CA2936534C (enExample) |
| DK (2) | DK2280070T3 (enExample) |
| ES (2) | ES2546829T3 (enExample) |
| PT (1) | PT2280070E (enExample) |
| WO (1) | WO2003010180A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| US8202846B2 (en) | 2000-03-16 | 2012-06-19 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| ES2546829T3 (es) | 2001-07-23 | 2015-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Métodos y composiciones para la inhibición mediada por iARN de la expresión génica en mamíferos |
| US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| US7101995B2 (en) * | 2001-08-27 | 2006-09-05 | Mirus Bio Corporation | Compositions and processes using siRNA, amphipathic compounds and polycations |
| ES2283592T3 (es) | 2001-09-25 | 2007-11-01 | Oncotherapy Science, Inc. | Gen y proteina relacionados con el carcinoma hepatocelular. |
| WO2003064625A2 (en) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Oligonucleotide compositions with enhanced efficiency |
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| EP1572902B1 (en) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| CA2482904A1 (en) * | 2002-04-18 | 2003-10-23 | Lynkeus Biotech Gmbh | Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification |
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| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| AU2003261231A1 (en) * | 2002-07-26 | 2004-02-16 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| EP2112229A3 (en) | 2002-11-25 | 2009-12-02 | Sequenom, Inc. | Methods for identifying risk of breast cancer and treatments thereof |
| US7781415B2 (en) * | 2003-02-07 | 2010-08-24 | Roche Madison Inc. | Process for delivering sirna to cardiac muscle tissue |
| CN102172408A (zh) * | 2003-02-28 | 2011-09-07 | 肿瘤疗法科学股份有限公司 | 抑制细胞生长的组合物和方法 |
| WO2004078928A2 (en) * | 2003-02-28 | 2004-09-16 | The Johns Hopkins University | T cell regulation |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| EP1636364A2 (en) * | 2003-06-06 | 2006-03-22 | Senesco Technologies, Inc. | INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A ( EIF-5A1) WITH ANTISENSE OLIGONUCLEOTIDES AND siRNAs AS ANTI-INFLAMMATORY THERAPEUTICS |
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| TWI350373B (en) | 2004-01-23 | 2011-10-11 | Oncotherapy Science Inc | Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators |
| JP2007527240A (ja) * | 2004-03-01 | 2007-09-27 | マサチューセッツ インスティテュート オブ テクノロジー | アレルギー性鼻炎および喘息のためのRNAiベースの治療 |
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| WO2005118640A2 (en) * | 2004-04-20 | 2005-12-15 | University Of Utah Research Foundation | A h+-gated ion channel |
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| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
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| US8765704B1 (en) | 2008-02-28 | 2014-07-01 | Novartis Ag | Modified small interfering RNA molecules and methods of use |
| ES2441791T3 (es) * | 2004-10-01 | 2014-02-06 | Novartis Vaccines And Diagnostics, Inc. | Moléculas de ARN de interferencia pequeñas modificadas y métodos de uso |
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| US20090005332A1 (en) * | 2004-12-30 | 2009-01-01 | Hauser Todd M | Compositions and Methods for Modulating Gene Expression Using Self-Protected Oligonucleotides |
| CN101111269A (zh) * | 2005-01-28 | 2008-01-23 | 协和发酵工业株式会社 | 抑制靶基因表达的组合物 |
| CN101189346A (zh) | 2005-02-28 | 2008-05-28 | 肿瘤疗法科学股份有限公司 | 乳腺癌相关基因znfn3a1 |
| EP1714970A1 (en) * | 2005-04-22 | 2006-10-25 | Universität des Saarlandes | Use of inhibitors of RNAse A-family enzymes for stabilizing oligonucleotides having RNA interfering activity |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
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| US7723314B1 (en) | 2005-10-28 | 2010-05-25 | Transderm, Inc. | Methods and compositions for treating pachyonychia congenita |
| EP1970078A4 (en) | 2006-01-11 | 2010-11-17 | Kyowa Hakko Kirin Co Ltd | COMPOSITION INHIBITING THE EXPRESSION OF A TARGET GENE OF THE OCULAR GLOBE AND REMEDY FOR OCULAR GLOBE DISEASE |
| WO2008016391A2 (en) | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| EP1991008A4 (en) * | 2006-02-27 | 2012-04-18 | Nikon Corp | IMAGE PROCESSING DEVICE FOR CORRECTING MASSIVE IMAGE PERCEPTION, IMAGE PROCESSING PROGRAM AND METHOD, AND ELECTRONIC CAMERA |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| EP2035439A4 (en) | 2006-06-05 | 2010-01-13 | Cancer Care Ontario | ASSESSMENT OF THE RISK OF COLORECTAL CANCER |
| US20080152654A1 (en) * | 2006-06-12 | 2008-06-26 | Exegenics, Inc., D/B/A Opko Health, Inc. | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| CA2679954A1 (en) | 2007-03-05 | 2008-09-12 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| EP2171082B1 (en) | 2007-06-14 | 2012-11-28 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
| WO2009005813A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| WO2010008562A2 (en) | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| CN102112136A (zh) | 2008-08-01 | 2011-06-29 | 协和发酵麒麟株式会社 | 抑制靶基因表达的组合物 |
| AU2009322279A1 (en) | 2008-12-04 | 2011-07-14 | Opko Pharmaceuticals, Llc | Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms |
| WO2010141511A2 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| EP2454371B1 (en) | 2009-07-13 | 2021-01-20 | Somagenics, Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
| JP5952197B2 (ja) | 2011-01-19 | 2016-07-13 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| JP6347743B2 (ja) | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
| CA2878314A1 (en) | 2012-07-16 | 2014-01-23 | Kyowa Hakko Kirin Co., Ltd. | Rnai pharmaceutical composition for suppressing expression of kras gene |
| AU2013308519A1 (en) | 2012-08-31 | 2015-04-09 | The General Hospital Corporation | Biotin complexes for treatment and diagnosis of Alzheimer's disease |
| CN104342453A (zh) | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
| US9545417B2 (en) | 2014-05-01 | 2017-01-17 | The Johns Hopkins University | Methods of inhibiting cancer stem cells with HMGA1 inhibitors |
| CN106794194A (zh) | 2014-06-30 | 2017-05-31 | 中央研究院 | 用于癌症治疗的介白素‑17受体b(il‑17rb)及其配体il‑17b之拮抗剂 |
| US20170216363A1 (en) | 2014-08-07 | 2017-08-03 | The Johns Hopkins University | Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases |
| US10265372B2 (en) | 2014-08-12 | 2019-04-23 | The Regents Of The University Of California | Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues |
| EP3188746B1 (en) | 2014-09-05 | 2024-06-19 | The Johns Hopkins University | Targeting capn9 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies |
| EA035799B1 (ru) | 2015-05-18 | 2020-08-12 | Зе Боард Оф Трастиз Оф Зе Леланд Стэнфорд Джуниор Юниверсити | Способ лечения взрослого млекопитающего от когнитивного нарушения, ассоциированного со старением |
| EP3340967B1 (en) | 2015-08-24 | 2024-05-22 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotide nanoparticles for the modulation of gene expression and uses thereof |
| WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| KR20190063473A (ko) | 2016-09-28 | 2019-06-07 | 블레이드 테라퓨틱스, 인크. | 칼페인 조정자 및 그 치료학적 용도 |
| WO2022076812A2 (en) | 2020-10-09 | 2022-04-14 | University Of Massachusetts | Targeting nrip1 to alleviate metabolic disease |
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| ATE240401T1 (de) | 1989-03-21 | 2003-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
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| CA2038839A1 (en) * | 1991-03-22 | 1992-09-23 | Jiang J. Liu | Method for detection of viral rna |
| ES2040615B1 (es) * | 1991-05-27 | 1994-05-16 | Nebrda Fernando Javi Bartolome | Procedimiento para el aislamiento y clonaje de cdnas derivados del virus c de la hepatitis. |
| US6030954A (en) * | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
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| IL159756A0 (en) | 2001-07-12 | 2004-06-20 | Univ Massachusetts | IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING |
| ES2546829T3 (es) | 2001-07-23 | 2015-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Métodos y composiciones para la inhibición mediada por iARN de la expresión génica en mamíferos |
| ATE519774T1 (de) | 2002-02-20 | 2011-08-15 | Sirna Therapeutics Inc | Durch eine störung der rna vermittelte inhibierung der genexpression des hepatitis c virus (hcv) mit kurzer, störender nukleinsäure (short interfering nucleic acid, sina) |
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2002
- 2002-07-19 ES ES10178509.5T patent/ES2546829T3/es not_active Expired - Lifetime
- 2002-07-19 JP JP2003515539A patent/JP2005508306A/ja not_active Withdrawn
- 2002-07-19 ES ES02761123T patent/ES2386775T3/es not_active Expired - Lifetime
- 2002-07-19 WO PCT/US2002/022869 patent/WO2003010180A1/en not_active Ceased
- 2002-07-19 US US10/200,002 patent/US20030153519A1/en not_active Abandoned
- 2002-07-19 EP EP02761123A patent/EP1409506B1/en not_active Expired - Lifetime
- 2002-07-19 DK DK10178509.5T patent/DK2280070T3/en active
- 2002-07-19 CA CA2936534A patent/CA2936534C/en not_active Expired - Lifetime
- 2002-07-19 EP EP10178509.5A patent/EP2280070B1/en not_active Expired - Lifetime
- 2002-07-19 PT PT101785095T patent/PT2280070E/pt unknown
- 2002-07-19 AT AT02761123T patent/ATE556720T1/de active
- 2002-07-19 CA CA2454183A patent/CA2454183C/en not_active Expired - Lifetime
- 2002-07-19 DK DK02761123.5T patent/DK1409506T3/da active
-
2010
- 2010-11-08 JP JP2010249697A patent/JP6055164B2/ja not_active Expired - Lifetime
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2013
- 2013-07-12 US US13/941,262 patent/US10517887B2/en not_active Expired - Fee Related
-
2014
- 2014-09-16 JP JP2014187281A patent/JP2015044809A/ja active Pending
-
2016
- 2016-08-17 JP JP2016159918A patent/JP6247355B2/ja not_active Expired - Lifetime
-
2019
- 2019-12-20 US US16/723,744 patent/US20200246370A1/en not_active Abandoned
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