JP2005508289A5 - - Google Patents
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- Publication number
- JP2005508289A5 JP2005508289A5 JP2002591455A JP2002591455A JP2005508289A5 JP 2005508289 A5 JP2005508289 A5 JP 2005508289A5 JP 2002591455 A JP2002591455 A JP 2002591455A JP 2002591455 A JP2002591455 A JP 2002591455A JP 2005508289 A5 JP2005508289 A5 JP 2005508289A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diethylcarbamoyl
- benzamide
- piperidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
- -1 CF 3 Chemical group 0.000 claims 2
- 230000002152 alkylating effect Effects 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- HUGSBYQOVYWCAP-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1,3-thiazol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2SC=CN=2)CC1 HUGSBYQOVYWCAP-UHFFFAOYSA-N 0.000 claims 1
- HSZIVHLCQPNQOE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=CN=2)CC1 HSZIVHLCQPNQOE-UHFFFAOYSA-N 0.000 claims 1
- YUWAIKLSVXKDQM-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-5-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=NC=2)CC1 YUWAIKLSVXKDQM-UHFFFAOYSA-N 0.000 claims 1
- VDUAGEPXEARSAO-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-pyrrol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=CC=2)CC1 VDUAGEPXEARSAO-UHFFFAOYSA-N 0.000 claims 1
- SKZXILXJTUIGSZ-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2OC=CC=2)CC1 SKZXILXJTUIGSZ-UHFFFAOYSA-N 0.000 claims 1
- JIXCNNYRTPMFJN-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC2=COC=C2)CC1 JIXCNNYRTPMFJN-UHFFFAOYSA-N 0.000 claims 1
- GRGQARAXZATPBE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2N=CC=CC=2)CC1 GRGQARAXZATPBE-UHFFFAOYSA-N 0.000 claims 1
- JZJSPCADPUUUEJ-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=NC=CC=2)CC1 JZJSPCADPUUUEJ-UHFFFAOYSA-N 0.000 claims 1
- GZJALTYZCKYWTC-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-4-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CN=CC=2)CC1 GZJALTYZCKYWTC-UHFFFAOYSA-N 0.000 claims 1
- XSTIMPUSVYWHJR-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2SC=CC=2)CC1 XSTIMPUSVYWHJR-UHFFFAOYSA-N 0.000 claims 1
- HUSCFKNTULOKOT-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC2=CSC=C2)CC1 HUSCFKNTULOKOT-UHFFFAOYSA-N 0.000 claims 1
- SJBURJKJEJSVCV-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(1-methylimidazol-2-yl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2N(C=CN=2)C)CC1 SJBURJKJEJSVCV-UHFFFAOYSA-N 0.000 claims 1
- KDIDFELALMETAT-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(F)=CC=2)CC1 KDIDFELALMETAT-UHFFFAOYSA-N 0.000 claims 1
- QFSXVMVWFGFILE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(OC)=CC=2)CC1 QFSXVMVWFGFILE-UHFFFAOYSA-N 0.000 claims 1
- JTJXQWZJBAJVGH-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-methylphenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(C)=CC=2)CC1 JTJXQWZJBAJVGH-UHFFFAOYSA-N 0.000 claims 1
- YCKPFIZUVGRVLD-UHFFFAOYSA-N 3-[n-(1-benzylpiperidin-4-yl)-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC=CC=2)CC1 YCKPFIZUVGRVLD-UHFFFAOYSA-N 0.000 claims 1
- ASVFDTYOAIGRTG-UHFFFAOYSA-N 3-[n-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C(=CC(Cl)=CC=2)Cl)CC1 ASVFDTYOAIGRTG-UHFFFAOYSA-N 0.000 claims 1
- VQRODKIKEPXZGG-UHFFFAOYSA-N 3-[n-[1-[(4-bromophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(Br)=CC=2)CC1 VQRODKIKEPXZGG-UHFFFAOYSA-N 0.000 claims 1
- RTYGKHNAXMRHOM-UHFFFAOYSA-N 3-[n-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(Cl)=CC=2)CC1 RTYGKHNAXMRHOM-UHFFFAOYSA-N 0.000 claims 1
- STXAVEHFKAXGOX-UHFFFAOYSA-N 3-bromobenzonitrile Chemical compound BrC1=CC=CC(C#N)=C1 STXAVEHFKAXGOX-UHFFFAOYSA-N 0.000 claims 1
- LDUPVXSXLZOQAF-UHFFFAOYSA-N 4-bromo-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=C(Br)C=C1 LDUPVXSXLZOQAF-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101769A SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| PCT/SE2002/000944 WO2002094782A1 (en) | 2001-05-18 | 2002-05-16 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derativatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508289A JP2005508289A (ja) | 2005-03-31 |
| JP2005508289A5 true JP2005508289A5 (OSRAM) | 2005-12-22 |
Family
ID=20284172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591455A Pending JP2005508289A (ja) | 2001-05-18 | 2002-05-16 | ４−（フェニル−（ピペリジン−４−イル）−アミノ）−ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7226933B2 (OSRAM) |
| EP (1) | EP1395555B1 (OSRAM) |
| JP (1) | JP2005508289A (OSRAM) |
| KR (1) | KR20030094425A (OSRAM) |
| CN (1) | CN1639123A (OSRAM) |
| AR (1) | AR033758A1 (OSRAM) |
| AT (1) | ATE313528T1 (OSRAM) |
| BG (1) | BG108330A (OSRAM) |
| BR (1) | BR0209670A (OSRAM) |
| CA (1) | CA2446311A1 (OSRAM) |
| CO (1) | CO5540317A2 (OSRAM) |
| CZ (1) | CZ20033089A3 (OSRAM) |
| DE (1) | DE60208192T2 (OSRAM) |
| EE (1) | EE200300554A (OSRAM) |
| HU (1) | HUP0401328A2 (OSRAM) |
| IL (1) | IL158628A0 (OSRAM) |
| IS (1) | IS7028A (OSRAM) |
| MX (1) | MXPA03010440A (OSRAM) |
| NO (1) | NO20035113D0 (OSRAM) |
| NZ (1) | NZ529398A (OSRAM) |
| PL (1) | PL366387A1 (OSRAM) |
| RU (1) | RU2003131966A (OSRAM) |
| SE (1) | SE0101769D0 (OSRAM) |
| SK (1) | SK13912003A3 (OSRAM) |
| WO (1) | WO2002094782A1 (OSRAM) |
| ZA (1) | ZA200308631B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12790A (en) * | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase. |
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| AU2007294968A1 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
| PT3233825T (pt) * | 2014-12-19 | 2020-07-15 | Pharmnovo Ab | Derivados de diarilmetilideno-piperidina e sua utilização como agonistas do recetor opioide delta |
| US20250084091A1 (en) * | 2021-05-04 | 2025-03-13 | The Texas A&M University System | Inhibitors of sars-cov-2 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) * | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| US4252812A (en) * | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) * | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) * | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| ATE306472T1 (de) | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| CA2683097A1 (en) | 1998-03-10 | 1999-09-16 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| US6552036B2 (en) * | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| WO2009028275A1 (ja) * | 2007-08-28 | 2009-03-05 | Konica Minolta Medical & Graphic, Inc. | シンチレータパネル |
-
2001
- 2001-05-18 SE SE0101769A patent/SE0101769D0/xx unknown
-
2002
- 2002-05-16 AR ARP020101814A patent/AR033758A1/es unknown
- 2002-05-16 NZ NZ529398A patent/NZ529398A/en unknown
- 2002-05-16 KR KR10-2003-7014946A patent/KR20030094425A/ko not_active Withdrawn
- 2002-05-16 PL PL02366387A patent/PL366387A1/xx not_active Application Discontinuation
- 2002-05-16 RU RU2003131966/04A patent/RU2003131966A/ru not_active Application Discontinuation
- 2002-05-16 US US10/477,852 patent/US7226933B2/en not_active Expired - Fee Related
- 2002-05-16 WO PCT/SE2002/000944 patent/WO2002094782A1/en not_active Ceased
- 2002-05-16 CN CNA028141601A patent/CN1639123A/zh active Pending
- 2002-05-16 EE EEP200300554A patent/EE200300554A/xx unknown
- 2002-05-16 SK SK1391-2003A patent/SK13912003A3/sk unknown
- 2002-05-16 EP EP02733702A patent/EP1395555B1/en not_active Expired - Lifetime
- 2002-05-16 CZ CZ20033089A patent/CZ20033089A3/cs unknown
- 2002-05-16 BR BR0209670-6A patent/BR0209670A/pt not_active IP Right Cessation
- 2002-05-16 CA CA002446311A patent/CA2446311A1/en not_active Abandoned
- 2002-05-16 IL IL15862802A patent/IL158628A0/xx unknown
- 2002-05-16 AT AT02733702T patent/ATE313528T1/de not_active IP Right Cessation
- 2002-05-16 JP JP2002591455A patent/JP2005508289A/ja active Pending
- 2002-05-16 DE DE60208192T patent/DE60208192T2/de not_active Expired - Fee Related
- 2002-05-16 MX MXPA03010440A patent/MXPA03010440A/es unknown
- 2002-05-16 HU HU0401328A patent/HUP0401328A2/hu unknown
-
2003
- 2003-11-05 ZA ZA200308631A patent/ZA200308631B/xx unknown
- 2003-11-07 BG BG108330A patent/BG108330A/bg unknown
- 2003-11-12 IS IS7028A patent/IS7028A/is unknown
- 2003-11-12 CO CO03100165A patent/CO5540317A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035113A patent/NO20035113D0/no not_active Application Discontinuation
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