JP2005507944A - ウイルスの抑制における改善およびその関連 - Google Patents

ウイルスの抑制における改善およびその関連 Download PDF

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Publication number
JP2005507944A
JP2005507944A JP2003541742A JP2003541742A JP2005507944A JP 2005507944 A JP2005507944 A JP 2005507944A JP 2003541742 A JP2003541742 A JP 2003541742A JP 2003541742 A JP2003541742 A JP 2003541742A JP 2005507944 A JP2005507944 A JP 2005507944A
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Japan
Prior art keywords
pharmaceutical composition
ribonucleoside
rna
composition according
general formula
Prior art date
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Withdrawn
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JP2003541742A
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English (en)
Japanese (ja)
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JP2005507944A5 (cg-RX-API-DMAC10.html
Inventor
ロークス，デイビッド
ブラウン，ダニエル
バルザリニ，ヤン
圭 森山
和雄 根岸
キャメロン，クレイグ
アーノルド，ジェーミー
カストロ，クリスチャン
コルニーバ，ビクトリア
グラシ，ジェイソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
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Filing date
Publication date
Priority claimed from GB0126701A external-priority patent/GB0126701D0/en
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of JP2005507944A publication Critical patent/JP2005507944A/ja
Publication of JP2005507944A5 publication Critical patent/JP2005507944A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2003541742A 2001-11-07 2002-11-07 ウイルスの抑制における改善およびその関連 Withdrawn JP2005507944A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126701A GB0126701D0 (en) 2001-11-07 2001-11-07 Improvements in or relating to induction of mutations in viruses
US10/207,005 US7049303B2 (en) 2001-11-07 2002-07-30 Inhibition of viruses
PCT/GB2002/005031 WO2003039450A2 (en) 2001-11-07 2002-11-07 Improvements in or relating to inhibition of viruses

Publications (2)

Publication Number Publication Date
JP2005507944A true JP2005507944A (ja) 2005-03-24
JP2005507944A5 JP2005507944A5 (cg-RX-API-DMAC10.html) 2006-01-12

Family

ID=26246745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003541742A Withdrawn JP2005507944A (ja) 2001-11-07 2002-11-07 ウイルスの抑制における改善およびその関連

Country Status (5)

Country Link
US (2) US7049303B2 (cg-RX-API-DMAC10.html)
EP (1) EP1441744A2 (cg-RX-API-DMAC10.html)
JP (1) JP2005507944A (cg-RX-API-DMAC10.html)
AU (1) AU2002337388A1 (cg-RX-API-DMAC10.html)
WO (1) WO2003039450A2 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505537A (ja) * 2002-09-30 2006-02-16 ジェネラブス テクノロジーズ，インコーポレイテッド Ｃ型肝炎ウイルスの感染を治療するためのヌクレオシド誘導体

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094768B2 (en) * 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
US7169918B2 (en) * 2003-10-27 2007-01-30 Genelabs Technologies, Inc. Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
MXPA06014909A (es) 2004-06-18 2007-02-28 Chiron Corp Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer.
AU2006222563A1 (en) * 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
EP3042660A3 (en) * 2008-04-15 2016-10-26 RFS Pharma, LLC. Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
JP5719840B2 (ja) * 2009-06-08 2015-05-20 武田薬品工業株式会社 Ｊａｋの阻害剤としてのジヒドロピロロナフチリジノン化合物
US9809616B2 (en) 2012-10-29 2017-11-07 Emory University Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer
WO2016106050A1 (en) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
RU2020116571A (ru) 2017-12-07 2021-11-22 Эмори Юниверсити N4-гидроксицитидин и производные и связанные с этим противовирусные применения
WO2023152709A1 (en) * 2022-02-14 2023-08-17 Arbutus Biopharma Corporation Rna polymerase inhibitors and methods using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8802687D0 (sv) 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
WO1990006319A1 (en) 1988-12-05 1990-06-14 Schering Corporation Antiviral dimers and trimers
DK62592D0 (cg-RX-API-DMAC10.html) * 1992-05-14 1992-05-14 Novo Nordisk As
US5773424A (en) 1994-12-16 1998-06-30 Research Corporation Technologies, Inc. Treatment of toxoplasmosis
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
AU727177B2 (en) 1996-10-16 2000-12-07 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
NZ507848A (en) * 1996-10-28 2005-01-28 Univ Washington Method of increasing the mutation rate of a virus in a non-human by administering an RNA nucleoside analogue to a virally infected cell
EA200700564A1 (ru) 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
JP2003524636A (ja) 1999-12-22 2003-08-19 インスパイアー ファーマシューティカルズ，インコーポレイティド プリン性受容体アゴニストによる胃腸管の処置方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505537A (ja) * 2002-09-30 2006-02-16 ジェネラブス テクノロジーズ，インコーポレイテッド Ｃ型肝炎ウイルスの感染を治療するためのヌクレオシド誘導体

Also Published As

Publication number Publication date
WO2003039450A3 (en) 2003-08-21
US7049303B2 (en) 2006-05-23
US20030130226A1 (en) 2003-07-10
AU2002337388A1 (en) 2003-05-19
US20050043268A1 (en) 2005-02-24
WO2003039450A2 (en) 2003-05-15
EP1441744A2 (en) 2004-08-04

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