JP2005507410A5 - - Google Patents
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- Publication number
- JP2005507410A5 JP2005507410A5 JP2003539666A JP2003539666A JP2005507410A5 JP 2005507410 A5 JP2005507410 A5 JP 2005507410A5 JP 2003539666 A JP2003539666 A JP 2003539666A JP 2003539666 A JP2003539666 A JP 2003539666A JP 2005507410 A5 JP2005507410 A5 JP 2005507410A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- bcr
- tyrophostin
- abl
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 7
- 108091000080 Phosphotransferase Proteins 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 102000020233 phosphotransferase Human genes 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- YJZSUCFGHXQWDM-UHFFFAOYSA-N 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemical compound OC1=CC=C(O)C(CNC=2C=CC(=CC=2)C(=O)OC23CC4CC(CC(C4)C2)C3)=C1 YJZSUCFGHXQWDM-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 7
- -1 4-methyl-piperazino-methyl Chemical group 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical class N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- AGCKSNJFAADRHH-UHFFFAOYSA-N 6,7-dimethoxy-2-thiophen-3-ylquinoxaline Chemical compound N1=C2C=C(OC)C(OC)=CC2=NC=C1C=1C=CSC=1 AGCKSNJFAADRHH-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 claims 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003248 quinolines Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 3
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 2
- 229960002411 imatinib Drugs 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33903201P | 2001-10-30 | 2001-10-30 | |
| PCT/IB2002/004430 WO2003037322A1 (en) | 2001-10-30 | 2002-10-25 | Combination of an atp-competitive inhibitor of bcr/abl kinase activity and a tyrphostin analog |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005507410A JP2005507410A (ja) | 2005-03-17 |
| JP2005507410A5 true JP2005507410A5 (enExample) | 2006-01-05 |
Family
ID=23327174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003539666A Pending JP2005507410A (ja) | 2001-10-30 | 2002-10-25 | Ｂｃｒ／ａｂｌキナーゼ活性のＡＴＰ競合的阻害剤とチロホスチンアナログとの組合せ剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060058307A1 (enExample) |
| EP (1) | EP1441717B1 (enExample) |
| JP (1) | JP2005507410A (enExample) |
| AT (1) | ATE369129T1 (enExample) |
| DE (1) | DE60221692D1 (enExample) |
| WO (1) | WO2003037322A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008520612A (ja) * | 2004-11-24 | 2008-06-19 | ノバルティス アクチエンゲゼルシャフト | ＪＡＫ阻害剤およびＢｃｒ−Ａｂｌ、Ｆｌｔ−３、ＦＡＫまたはＲＡＦキナーゼ阻害剤のうち少なくとも１個の組合せ |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
-
2002
- 2002-10-25 JP JP2003539666A patent/JP2005507410A/ja active Pending
- 2002-10-25 EP EP02783345A patent/EP1441717B1/en not_active Expired - Lifetime
- 2002-10-25 US US10/493,788 patent/US20060058307A1/en not_active Abandoned
- 2002-10-25 DE DE60221692T patent/DE60221692D1/de not_active Expired - Lifetime
- 2002-10-25 AT AT02783345T patent/ATE369129T1/de not_active IP Right Cessation
- 2002-10-25 WO PCT/IB2002/004430 patent/WO2003037322A1/en not_active Ceased
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