JP2005506293A5 - - Google Patents

Info

Publication number

JP2005506293A5

JP2005506293A5 JP2002572907A JP2002572907A JP2005506293A5 JP 2005506293 A5 JP2005506293 A5 JP 2005506293A5 JP 2002572907 A JP2002572907 A JP 2002572907A JP 2002572907 A JP2002572907 A JP 2002572907A JP 2005506293 A5 JP2005506293 A5 JP 2005506293A5

Authority

JP

Japan

Prior art keywords

composition

ocular degeneration

polypeptide

degeneration

ocular

Prior art date

2002-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 45
• 230000007850 degeneration Effects 0.000 claims 19
• 229920001184 polypeptide Polymers 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 238000009472 formulation Methods 0.000 claims 6
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 4
• 206010013774 Dry eye Diseases 0.000 claims 4
• UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical group N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims 4
• 102100035000 Thymosin beta-4 Human genes 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 239000002674 ointment Substances 0.000 claims 4
• 108010079996 thymosin beta(4) Proteins 0.000 claims 4
• 102000001708 Protein Isoforms Human genes 0.000 claims 2
• 108010029485 Protein Isoforms Proteins 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 239000006071 cream Substances 0.000 claims 2
• 239000006185 dispersion Substances 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000000499 gel Substances 0.000 claims 2
• 239000000017 hydrogel Substances 0.000 claims 2
• 239000011499 joint compound Substances 0.000 claims 2
• 239000006210 lotion Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 239000007921 spray Substances 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• 230000036425 denaturation Effects 0.000 claims 1
• 238000004925 denaturation Methods 0.000 claims 1