JP2005506091A5 - - Google Patents
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- Publication number
- JP2005506091A5 JP2005506091A5 JP2003538385A JP2003538385A JP2005506091A5 JP 2005506091 A5 JP2005506091 A5 JP 2005506091A5 JP 2003538385 A JP2003538385 A JP 2003538385A JP 2003538385 A JP2003538385 A JP 2003538385A JP 2005506091 A5 JP2005506091 A5 JP 2005506091A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- formula
- alkyl ester
- acid alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims 5
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 4
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 claims 2
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- -1 (R) -8-chloro-6-hydroxy-octane Chemical compound 0.000 claims 1
- 240000001929 Lactobacillus brevis Species 0.000 claims 1
- 235000013957 Lactobacillus brevis Nutrition 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10152113A DE10152113C1 (de) | 2001-10-23 | 2001-10-23 | Verfahren zur Herstellung von (R)- und (S)-8-Chlor-6-hydroxy-octansäurealkylestern durch enzymatische Reduktion |
| PCT/EP2002/011470 WO2003035885A1 (de) | 2001-10-23 | 2002-10-14 | Verfahren zur herstellung von (r)- und (s)-8-chlor-6-hydroxy-octansäurealkylestern durch enzymatische reduktion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506091A JP2005506091A (ja) | 2005-03-03 |
| JP2005506091A5 true JP2005506091A5 (enExample) | 2005-12-22 |
Family
ID=7703317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538385A Withdrawn JP2005506091A (ja) | 2001-10-23 | 2002-10-14 | 酵素的還元による（ｒ）−および（ｓ）−８−クロロ−６−ヒドロキシ−オクタン酸アルキルエステルの製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7157253B2 (enExample) |
| EP (1) | EP1440158A1 (enExample) |
| JP (1) | JP2005506091A (enExample) |
| DE (1) | DE10152113C1 (enExample) |
| WO (1) | WO2003035885A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012017026A1 (de) | 2012-08-28 | 2014-03-06 | Forschungszentrum Jülich GmbH | Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen |
| US10294479B2 (en) | 2015-03-04 | 2019-05-21 | East China University Of Science And Technology | Candida carbonyl reductase and method for preparing (R)-lipoic acid precursor |
| CN106083811B (zh) * | 2016-06-14 | 2019-02-05 | 苏州富士莱医药股份有限公司 | (R)-α-硫辛酸的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4037440A1 (de) * | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
| DE19533882A1 (de) | 1995-09-13 | 1997-03-20 | Dresden Arzneimittel | Herstellung und Verwendung der reinen Enantiomere der 8-Halogen-6-hydroxyoctansäuren, ihrer Alkylester und ihrer Salze mit reinen Enantiomeren des alpha-Methylbenzylamins |
| JP4012299B2 (ja) * | 1998-02-25 | 2007-11-21 | ダイセル化学工業株式会社 | ハロゲン置換を含む光学活性アルコールの製造方法 |
| WO2002010422A1 (de) | 2000-07-27 | 2002-02-07 | Viatris Gmbh & Co. Kg | Verfahren zur enantioselektiven reduktion von 8-chlor-6-oxo-octansäurealkylestern |
| DE10056025A1 (de) * | 2000-07-27 | 2002-02-07 | Asta Medica Ag | Verfahren zur enantioselektiven Reduktion von 8-Chlor-6oxo-octansäurealkylestern |
-
2001
- 2001-10-23 DE DE10152113A patent/DE10152113C1/de not_active Withdrawn - After Issue
-
2002
- 2002-10-14 WO PCT/EP2002/011470 patent/WO2003035885A1/de not_active Ceased
- 2002-10-14 EP EP02779483A patent/EP1440158A1/de not_active Withdrawn
- 2002-10-14 JP JP2003538385A patent/JP2005506091A/ja not_active Withdrawn
- 2002-10-14 US US10/493,630 patent/US7157253B2/en not_active Expired - Fee Related
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