JP2005505545A - 高血圧及び心不全を減少させる方法 - Google Patents

高血圧及び心不全を減少させる方法 Download PDF

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JP2005505545A
JP2005505545A JP2003524516A JP2003524516A JP2005505545A JP 2005505545 A JP2005505545 A JP 2005505545A JP 2003524516 A JP2003524516 A JP 2003524516A JP 2003524516 A JP2003524516 A JP 2003524516A JP 2005505545 A JP2005505545 A JP 2005505545A
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heart
tyrphostin
hypertension
hypertrophy
ischemia
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JP2003524516A
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Japanese (ja)
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JP2005505545A5 (enExample
Inventor
エム エイ キュー シッディキ
エデュアード マスカレノ
ダニエル エル ベックルズ
Original Assignee
ザ リサーチ ファウンデーション オブ ステイト ユニヴァーシティ オブ ニューヨーク
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Publication of JP2005505545A publication Critical patent/JP2005505545A/ja
Publication of JP2005505545A5 publication Critical patent/JP2005505545A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003524516A 2001-08-31 2002-07-23 高血圧及び心不全を減少させる方法 Pending JP2005505545A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/945,192 US6433018B1 (en) 2001-08-31 2001-08-31 Method for reducing hypertrophy and ischemia
PCT/US2002/023444 WO2003020202A2 (en) 2001-08-31 2002-07-23 Method for reducing hypertension and heart failure

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010180146A Division JP2010285455A (ja) 2001-08-31 2010-08-11 高血圧及び心不全を減少させる方法

Publications (2)

Publication Number Publication Date
JP2005505545A true JP2005505545A (ja) 2005-02-24
JP2005505545A5 JP2005505545A5 (enExample) 2006-01-05

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JP2003524516A Pending JP2005505545A (ja) 2001-08-31 2002-07-23 高血圧及び心不全を減少させる方法
JP2010180146A Pending JP2010285455A (ja) 2001-08-31 2010-08-11 高血圧及び心不全を減少させる方法

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JP2010180146A Pending JP2010285455A (ja) 2001-08-31 2010-08-11 高血圧及び心不全を減少させる方法

Country Status (11)

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US (2) US6433018B1 (enExample)
EP (1) EP1427401A4 (enExample)
JP (2) JP2005505545A (enExample)
KR (1) KR20040050894A (enExample)
AU (1) AU2002313700B2 (enExample)
BR (1) BR0212252A (enExample)
CA (1) CA2458798C (enExample)
MX (1) MXPA04001913A (enExample)
NZ (1) NZ531693A (enExample)
WO (1) WO2003020202A2 (enExample)
ZA (1) ZA200402540B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011126258A (ja) * 2009-12-21 2011-06-30 Panasonic Electric Works Co Ltd 繊維ボードの製造方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433018B1 (en) * 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US20050038450A1 (en) * 2003-06-03 2005-02-17 Ping Hu Methods and apparatus for minimally invasive transverse aortic banding
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
US20050130893A1 (en) * 2003-09-30 2005-06-16 Joan Smith-Sonneborn Use of opioids in prevention of and recovery from a stress-induced crash in blood pressure
PT1701941E (pt) 2003-12-11 2012-08-03 Univ Texas Compostos para o tratamento de doenças proliferativas celulares
TWI398261B (zh) * 2003-12-17 2013-06-11 Alcon Inc 血清類澱粉a基因於診斷及治療青光眼及鑑定抗青光眼劑上之用途
US7662389B2 (en) * 2003-12-17 2010-02-16 Alcon, Inc. Use of serum amyloid A gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents
US20100113481A1 (en) * 2003-12-17 2010-05-06 Alcon Research, Ltd. Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents
US8691877B2 (en) * 2004-10-15 2014-04-08 Palo Alto Investors Methods and compositions for treating a disease condition in a subject
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
RU2485106C2 (ru) * 2005-06-08 2013-06-20 Райджел Фамэсьютикэлз, Инк. Соединения, проявляющие активность в отношении jak-киназы (варианты), способ лечения заболеваний, опосредованных jak-киназой, способ ингибирования активности jak-киназы (варианты), фармацевтическая композиция на основе указанных соединений
US10517876B2 (en) 2005-11-16 2019-12-31 Cti Biopharma Corp. Oxygen linked pyrimidine derivatives
CN101365703B (zh) 2005-11-16 2013-11-06 S*Bio私人有限公司 杂烷基连接的嘧啶衍生物
US20100242139A1 (en) * 2006-01-13 2010-09-23 President And Fellows Of Harvard College Xenohormesis based compositions and methods
US8962643B2 (en) * 2006-02-24 2015-02-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
AU2007220047B2 (en) * 2006-02-28 2013-08-01 Ym Biosciences Australia Pty Ltd Inhibition of JAK2 as a treatment of pulmonary arterial hypertension
BRPI0709916B8 (pt) * 2006-03-31 2021-05-25 Univ Texas drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas
HUE029188T2 (en) 2007-03-12 2017-03-28 Ym Biosciences Australia Pty Phenylamino-pyrimidine compounds and their use
HRP20170317T1 (hr) * 2008-02-15 2017-04-21 Rigel Pharmaceuticals, Inc. Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza
PT2323993E (pt) 2008-04-16 2015-10-12 Portola Pharm Inc 2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US8258144B2 (en) * 2008-04-22 2012-09-04 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
NZ590372A (en) 2008-07-08 2012-09-28 Univ Texas Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
MX2011006206A (es) 2008-12-11 2011-07-20 S Bio Pte Ltd Sal de citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26- triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5 ,8,10,12(27),16,21,23-decaeno.
CA2768543C (en) * 2009-07-28 2017-06-20 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
EP2975027A1 (en) 2010-11-01 2016-01-20 Portola Pharmaceuticals, Inc. Nicotinamides as jak kinase modulators
US8877760B2 (en) 2011-11-23 2014-11-04 Portola Pharmaceuticals, Inc. Substituted pyrazine-2-carboxamide kinase inhibitors
US8809359B2 (en) 2012-06-29 2014-08-19 Ym Biosciences Australia Pty Ltd Phenyl amino pyrimidine bicyclic compounds and uses thereof
EP2903970A4 (en) 2012-10-08 2016-11-30 Portola Pharm Inc SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS
TW202134236A (zh) 2014-06-12 2021-09-16 美商西爾拉癌症醫學公司 N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA2012634A1 (en) * 1990-03-20 1991-09-20 Hassan Salari Tyrphostins for treatment of allergic, inflammatory and cardiovascular diseases
US5443836A (en) 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US6255296B1 (en) 1994-01-11 2001-07-03 Endomatrix, Inc. Composition and method for treating a patient susceptible to or suffering from a cardiovascular disorder or disease
IL119069A0 (en) 1996-08-14 1996-11-14 Mor Research Applic Ltd Pharmaceutical composition comprising tyrphostins
US6358954B1 (en) 1999-11-09 2002-03-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
US6433018B1 (en) * 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
DE602006000402T8 (de) * 2006-06-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
JPN6008060998, MALLOY,L.G. et al, "Tyrosine kinase inhibition suppresses angiotensin contraction in hypertensive and normotensive small", Life Sci, 1996, Vol.58, No.19, p.PL317−24 *
JPN6008061014, SAURO,M.D. et al, "Tyrphostin attenuates platelet−derived growth factor−induced contraction in aortic smooth muscle thr", J Pharmacol Exp Ther, 1993, Vol.267, No.3, p.1119−25 *
JPN6008061016, メルクマニュアル 日本語版, 1999, 第17版, 第1674−1676頁, 日経BP社 *
JPN6008061018, "JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion", Circulation, 200107, Vol.104, No.3, p.325−9 *
JPN6009043351, AMERICAN JOURNAL OF HYPERTENSION, 200104, Vol.14, No.4, Part 2, 151A−152A *
JPN6009043353, RUETTEN,H. et al, "Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endo", Br J Pharmacol, 1997, Vol.122, No.1, p.59−70 *
JPN6009043355, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 200106, Vol.33, No.6, A10 *
JPN6009043357, MANABE,T. et al, "Hypertrophic stimuli augment expression of cMG1/ERF−1, a putative zinc−finger motif transcription fa", FEBS Lett, 1999, Vol.463, No.1−2, p.39−42 *
JPN6009043358, "Cardiotrophin−1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine", Hypertension, 2000, Vol.35, No.6, p.1191−6 *
JPN6010018321, "高血圧性肥大心左室心筋におけるJAK−STAT系の機械的伸展負荷に対する活性化亢進と内因性アンジオテンシンII", Japanese Circulation Journal, 2000, Vol.64, Suppl.1, 第634頁 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011126258A (ja) * 2009-12-21 2011-06-30 Panasonic Electric Works Co Ltd 繊維ボードの製造方法

Also Published As

Publication number Publication date
WO2003020202A2 (en) 2003-03-13
EP1427401A4 (en) 2009-04-29
ZA200402540B (en) 2005-06-29
BR0212252A (pt) 2004-09-14
US7235588B2 (en) 2007-06-26
AU2002313700B2 (en) 2007-04-26
MXPA04001913A (es) 2004-06-18
US20040266661A1 (en) 2004-12-30
WO2003020202A3 (en) 2003-08-28
KR20040050894A (ko) 2004-06-17
JP2010285455A (ja) 2010-12-24
US6433018B1 (en) 2002-08-13
CA2458798C (en) 2013-06-25
CA2458798A1 (en) 2003-03-13
NZ531693A (en) 2006-05-26
EP1427401A2 (en) 2004-06-16

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