JP2005501091A5 - - Google Patents

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Publication number
JP2005501091A5
JP2005501091A5 JP2003519060A JP2003519060A JP2005501091A5 JP 2005501091 A5 JP2005501091 A5 JP 2005501091A5 JP 2003519060 A JP2003519060 A JP 2003519060A JP 2003519060 A JP2003519060 A JP 2003519060A JP 2005501091 A5 JP2005501091 A5 JP 2005501091A5
Authority
JP
Japan
Prior art keywords
alkyl
pharmaceutically acceptable
hydrolyzed
vivo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003519060A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005501091A (ja
Filing date
Publication date
Priority claimed from GBGB0119474.5A external-priority patent/GB0119474D0/en
Application filed filed Critical
Publication of JP2005501091A publication Critical patent/JP2005501091A/ja
Publication of JP2005501091A5 publication Critical patent/JP2005501091A5/ja
Pending legal-status Critical Current

Links

JP2003519060A 2001-08-09 2002-08-08 アリールピペラジンとアリールピペリジン、およびメタロプロテイナーゼ阻害剤としてのそれらの使用 Pending JP2005501091A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119474.5A GB0119474D0 (en) 2001-08-09 2001-08-09 Compounds
PCT/SE2002/001436 WO2003014111A1 (en) 2001-08-09 2002-08-08 Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents

Publications (2)

Publication Number Publication Date
JP2005501091A JP2005501091A (ja) 2005-01-13
JP2005501091A5 true JP2005501091A5 (https=) 2006-01-12

Family

ID=9920126

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003519060A Pending JP2005501091A (ja) 2001-08-09 2002-08-08 アリールピペラジンとアリールピペリジン、およびメタロプロテイナーゼ阻害剤としてのそれらの使用

Country Status (5)

Country Link
US (2) US7153857B2 (https=)
EP (1) EP1417201A1 (https=)
JP (1) JP2005501091A (https=)
GB (1) GB0119474D0 (https=)
WO (1) WO2003014111A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
DE10250708A1 (de) * 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
DE102004017930A1 (de) * 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US20050245529A1 (en) * 2004-04-14 2005-11-03 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
WO2008076883A2 (en) 2006-12-15 2008-06-26 Abraxis Bioscience, Inc. Triazine derivatives and their therapeutical applications
JP5785940B2 (ja) 2009-06-09 2015-09-30 アブラクシス バイオサイエンス， エルエルシー トリアジン誘導体類及びそれらの治療応用
EP2440053A4 (en) 2009-06-09 2012-10-31 California Capital Equity Llc BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF

Family Cites Families (30)

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Publication number Priority date Publication date Assignee Title
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5817822A (en) * 1994-06-24 1998-10-06 Novartis Corporation Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
WO1998005635A1 (en) 1996-08-07 1998-02-12 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
AU743901B2 (en) 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) * 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
PL334846A1 (en) 1997-01-23 2000-03-27 Hoffmann La Roche Sulphamidic inhibitors of metaloproteases
US6482827B1 (en) * 1997-07-10 2002-11-19 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
WO1999002510A1 (en) 1997-07-10 1999-01-21 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
US6294573B1 (en) * 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6235786B1 (en) * 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6403632B1 (en) * 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
ZA988967B (en) * 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
GB9725782D0 (en) * 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
AU735929B2 (en) 1998-01-30 2001-07-19 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives
US6479502B1 (en) * 1998-08-29 2002-11-12 British Biotech Pharmaceuticals Hydroxamic acid derivatives as proteinase inhibitors
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
HRP20010660A2 (en) * 1999-02-08 2005-02-28 G.D. Searle & Co Sulfamato hydroxamic acid metalloprotease inhibitor
US6511993B1 (en) * 1999-06-03 2003-01-28 Kevin Neil Dack Metalloprotease inhibitors
JP2003501414A (ja) 1999-06-04 2003-01-14 アストラゼネカ・アクチエボラーグ メタロプロテイナーゼの阻害剤
WO2001062742A1 (en) 2000-02-21 2001-08-30 Astrazeneca Ab Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases
KR20020079882A (ko) 2000-02-21 2002-10-19 아스트라제네카 아베 아릴피페라진 및 아릴피페리딘 및 금속단백질분해효소억제제로서의 그의 용도
JP2003524007A (ja) 2000-02-21 2003-08-12 アストラゼネカ・アクチエボラーグ アリールピペラジン類およびそれらのメタロプロテイナーゼ阻害剤（ｍｍｐ）としての使用
EP1282614B1 (en) * 2000-05-15 2003-11-12 Darwin Discovery Limited Hydroxamic acid derivatives
GB0119472D0 (en) 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119473D0 (en) 2001-08-09 2001-10-03 Astrazeneca Compounds

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