JP2005500019A - 改良された遺伝子発現 - Google Patents

改良された遺伝子発現 Download PDF

Info

Publication number
JP2005500019A
JP2005500019A JP2002580040A JP2002580040A JP2005500019A JP 2005500019 A JP2005500019 A JP 2005500019A JP 2002580040 A JP2002580040 A JP 2002580040A JP 2002580040 A JP2002580040 A JP 2002580040A JP 2005500019 A JP2005500019 A JP 2005500019A
Authority
JP
Japan
Prior art keywords
vector
nucleic acid
selectable marker
gene
isolated polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002580040A
Other languages
English (en)
Japanese (ja)
Inventor
ステファン ゲレイント ウィリアム,
ロバート ラハラン クロムビー,
Original Assignee
エムエル ラボラトリーズ ピーエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0108605A external-priority patent/GB0108605D0/en
Priority claimed from GB0109335A external-priority patent/GB0109335D0/en
Application filed by エムエル ラボラトリーズ ピーエルシー filed Critical エムエル ラボラトリーズ ピーエルシー
Publication of JP2005500019A publication Critical patent/JP2005500019A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/46Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2002580040A 2001-04-05 2002-04-05 改良された遺伝子発現 Pending JP2005500019A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28160501P 2001-04-05 2001-04-05
GB0108605A GB0108605D0 (en) 2001-04-05 2001-04-05 Improved gene expression
GB0109335A GB0109335D0 (en) 2001-04-17 2001-04-17 Improved gene expression
US29867501P 2001-06-15 2001-06-15
PCT/GB2002/001479 WO2002081677A2 (en) 2001-04-05 2002-04-05 Improved gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008243399A Division JP2009017886A (ja) 2001-04-05 2008-09-22 改良された遺伝子発現

Publications (1)

Publication Number Publication Date
JP2005500019A true JP2005500019A (ja) 2005-01-06

Family

ID=27447937

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2002580040A Pending JP2005500019A (ja) 2001-04-05 2002-04-05 改良された遺伝子発現
JP2008243399A Pending JP2009017886A (ja) 2001-04-05 2008-09-22 改良された遺伝子発現
JP2009266880A Pending JP2010042033A (ja) 2001-04-05 2009-11-24 改良された遺伝子発現
JP2010148212A Pending JP2010259439A (ja) 2001-04-05 2010-06-29 改良された遺伝子発現
JP2011142362A Pending JP2011193881A (ja) 2001-04-05 2011-06-27 改良された遺伝子発現

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2008243399A Pending JP2009017886A (ja) 2001-04-05 2008-09-22 改良された遺伝子発現
JP2009266880A Pending JP2010042033A (ja) 2001-04-05 2009-11-24 改良された遺伝子発現
JP2010148212A Pending JP2010259439A (ja) 2001-04-05 2010-06-29 改良された遺伝子発現
JP2011142362A Pending JP2011193881A (ja) 2001-04-05 2011-06-27 改良された遺伝子発現

Country Status (9)

Country Link
EP (2) EP2224010B1 (enExample)
JP (5) JP2005500019A (enExample)
CN (1) CN1500147B (enExample)
AT (1) ATE460493T1 (enExample)
AU (1) AU2002242872B2 (enExample)
CA (1) CA2443275C (enExample)
DE (1) DE60235616D1 (enExample)
ES (1) ES2339428T3 (enExample)
WO (1) WO2002081677A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539781A (ja) * 2005-05-17 2008-11-20 ミリポア・コーポレイション 改良された発現エレメント

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7812148B2 (en) 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
JP4709743B2 (ja) * 2003-02-01 2011-06-22 ミリポア・コーポレイション 改善された発現エレメント
DK1776460T3 (da) 2004-08-03 2010-04-12 Geneart Ag Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdet
GB0504587D0 (en) 2005-03-05 2005-04-13 Ml Lab Plc Vectors comprising guinea pig CMV regulatory elements
ES2330784T3 (es) * 2005-03-05 2009-12-15 Millipore Corporation Vectores que comprenden nuevos elementos reguladores.
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
CN104531699B (zh) * 2014-10-09 2017-03-15 河南农业大学 一种增强外源基因表达的猪的ucoe调控元件片段
WO2018175153A1 (en) * 2017-03-19 2018-09-27 Applied Stemcell, Inc. Novel integration sites and uses thereof
EP3805396B1 (en) * 2018-05-24 2024-09-11 National University Corporation Hokkaido University Novel vector and use thereof
CN116790606B (zh) * 2023-08-23 2023-11-07 威瑞生物科技(昆明)有限责任公司 一种遍在染色质开放表达元件、重组表达载体及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0918874T3 (da) 1996-08-16 2001-05-14 Medical Res Council Selvreplikerende episomale ekspressionsvektorer, som giver vævsspecifik genekspression
WO2000005393A2 (en) * 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
KR100996016B1 (ko) * 2000-09-20 2010-11-22 밀리포어 코포레이션 폴리뉴클레오티드

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539781A (ja) * 2005-05-17 2008-11-20 ミリポア・コーポレイション 改良された発現エレメント

Also Published As

Publication number Publication date
AU2002242872B2 (en) 2006-12-14
JP2010259439A (ja) 2010-11-18
JP2011193881A (ja) 2011-10-06
CA2443275A1 (en) 2002-10-17
ATE460493T1 (de) 2010-03-15
AU2002242872A2 (en) 2002-10-21
WO2002081677A2 (en) 2002-10-17
CN1500147B (zh) 2011-05-04
DE60235616D1 (de) 2010-04-22
JP2010042033A (ja) 2010-02-25
WO2002081677A3 (en) 2002-12-19
JP2009017886A (ja) 2009-01-29
CN1500147A (zh) 2004-05-26
EP2224010B1 (en) 2012-06-20
EP1373535B1 (en) 2010-03-10
EP2224010A1 (en) 2010-09-01
EP1373535A2 (en) 2004-01-02
CA2443275C (en) 2013-02-05
ES2339428T3 (es) 2010-05-20

Similar Documents

Publication Publication Date Title
JP2011193881A (ja) 改良された遺伝子発現
JP5051738B2 (ja) 人工遍在的クロマチン開放エレメント(ucoe)
AU2001290067A1 (en) Artificial ubiquitous chromatin opening elements (UCOE)
AU2002242872A1 (en) Improved gene expression
US7812148B2 (en) Vectors comprising CpG islands without position effect varigation and having increased expression
US6949361B2 (en) Polynucleotide
CN1748034B (zh) 改进的表达元件
EP1587934B1 (en) Improved genetic elements providing high levels of expression
ES2387951T3 (es) Expresión génica mejorada
EP1856267B1 (en) Vectors comprising novel regulatory elements

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050329

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20060706

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20070713

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080327

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080618

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080625

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080716

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080724

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080819

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080922

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081030

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090129

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090205

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090227

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20090227

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090525