CN1500147B - 改进的基因表达 - Google Patents

改进的基因表达 Download PDF

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Publication number
CN1500147B
CN1500147B CN028077113A CN02807711A CN1500147B CN 1500147 B CN1500147 B CN 1500147B CN 028077113 A CN028077113 A CN 028077113A CN 02807711 A CN02807711 A CN 02807711A CN 1500147 B CN1500147 B CN 1500147B
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CN
China
Prior art keywords
gene
carrier
nucleic acid
isolating polynucleotide
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN028077113A
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English (en)
Chinese (zh)
Other versions
CN1500147A (zh
Inventor
斯蒂芬·杰兰特·威廉斯
罗伯特·拉克伦·克龙比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EMD Millipore Corp
Original Assignee
ML Laboratories PLC
Millipore Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0108605A external-priority patent/GB0108605D0/en
Priority claimed from GB0109335A external-priority patent/GB0109335D0/en
Application filed by ML Laboratories PLC, Millipore Corp filed Critical ML Laboratories PLC
Publication of CN1500147A publication Critical patent/CN1500147A/zh
Application granted granted Critical
Publication of CN1500147B publication Critical patent/CN1500147B/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN028077113A 2001-04-05 2002-04-05 改进的基因表达 Expired - Fee Related CN1500147B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US28160501P 2001-04-05 2001-04-05
GB0108605A GB0108605D0 (en) 2001-04-05 2001-04-05 Improved gene expression
US60/281,605 2001-04-05
GB0108605.7 2001-04-05
GB0109335A GB0109335D0 (en) 2001-04-17 2001-04-17 Improved gene expression
GB0109335.0 2001-04-17
US29867501P 2001-06-15 2001-06-15
US60/298,675 2001-06-15
PCT/GB2002/001479 WO2002081677A2 (en) 2001-04-05 2002-04-05 Improved gene expression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011100636973A Division CN102206633A (zh) 2001-04-05 2002-04-05 改进的基因表达

Publications (2)

Publication Number Publication Date
CN1500147A CN1500147A (zh) 2004-05-26
CN1500147B true CN1500147B (zh) 2011-05-04

Family

ID=27447937

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028077113A Expired - Fee Related CN1500147B (zh) 2001-04-05 2002-04-05 改进的基因表达

Country Status (9)

Country Link
EP (2) EP2224010B1 (enExample)
JP (5) JP2005500019A (enExample)
CN (1) CN1500147B (enExample)
AT (1) ATE460493T1 (enExample)
AU (1) AU2002242872B2 (enExample)
CA (1) CA2443275C (enExample)
DE (1) DE60235616D1 (enExample)
ES (1) ES2339428T3 (enExample)
WO (1) WO2002081677A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7812148B2 (en) 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
JP4709743B2 (ja) * 2003-02-01 2011-06-22 ミリポア・コーポレイション 改善された発現エレメント
DK1776460T3 (da) 2004-08-03 2010-04-12 Geneart Ag Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdet
GB0504587D0 (en) 2005-03-05 2005-04-13 Ml Lab Plc Vectors comprising guinea pig CMV regulatory elements
ES2330784T3 (es) * 2005-03-05 2009-12-15 Millipore Corporation Vectores que comprenden nuevos elementos reguladores.
GB0509965D0 (en) * 2005-05-17 2005-06-22 Ml Lab Plc Improved expression elements
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
CN104531699B (zh) * 2014-10-09 2017-03-15 河南农业大学 一种增强外源基因表达的猪的ucoe调控元件片段
WO2018175153A1 (en) * 2017-03-19 2018-09-27 Applied Stemcell, Inc. Novel integration sites and uses thereof
EP3805396B1 (en) * 2018-05-24 2024-09-11 National University Corporation Hokkaido University Novel vector and use thereof
CN116790606B (zh) * 2023-08-23 2023-11-07 威瑞生物科技(昆明)有限责任公司 一种遍在染色质开放表达元件、重组表达载体及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005393A2 (en) * 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0918874T3 (da) 1996-08-16 2001-05-14 Medical Res Council Selvreplikerende episomale ekspressionsvektorer, som giver vævsspecifik genekspression
KR100996016B1 (ko) * 2000-09-20 2010-11-22 밀리포어 코포레이션 폴리뉴클레오티드

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005393A2 (en) * 1998-07-21 2000-02-03 Cobra Therapeutics Limited A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Talgat Zhuma.Human HMG box transcription factor HBP1: a role in hCD2LCR function.EMBO Journal18.1999,p6396-6406. *

Also Published As

Publication number Publication date
AU2002242872B2 (en) 2006-12-14
JP2010259439A (ja) 2010-11-18
JP2005500019A (ja) 2005-01-06
JP2011193881A (ja) 2011-10-06
CA2443275A1 (en) 2002-10-17
ATE460493T1 (de) 2010-03-15
AU2002242872A2 (en) 2002-10-21
WO2002081677A2 (en) 2002-10-17
DE60235616D1 (de) 2010-04-22
JP2010042033A (ja) 2010-02-25
WO2002081677A3 (en) 2002-12-19
JP2009017886A (ja) 2009-01-29
CN1500147A (zh) 2004-05-26
EP2224010B1 (en) 2012-06-20
EP1373535B1 (en) 2010-03-10
EP2224010A1 (en) 2010-09-01
EP1373535A2 (en) 2004-01-02
CA2443275C (en) 2013-02-05
ES2339428T3 (es) 2010-05-20

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Owner name: EMD MILLIPORE CORPORATION

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Granted publication date: 20110504

Termination date: 20140405