JP2005237328A5 - - Google Patents
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- Publication number
- JP2005237328A5 JP2005237328A5 JP2004053795A JP2004053795A JP2005237328A5 JP 2005237328 A5 JP2005237328 A5 JP 2005237328A5 JP 2004053795 A JP2004053795 A JP 2004053795A JP 2004053795 A JP2004053795 A JP 2004053795A JP 2005237328 A5 JP2005237328 A5 JP 2005237328A5
- Authority
- JP
- Japan
- Prior art keywords
- base sequence
- immunostimulatory oligonucleotide
- immunomodulator
- seq
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004053795A JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
| PCT/JP2005/003693 WO2005083076A1 (ja) | 2004-02-27 | 2005-02-25 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
| US10/590,761 US7718623B2 (en) | 2004-02-27 | 2005-02-25 | Immunostimulatory oligonucleotide that induces interferon alpha |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004053795A JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005237328A JP2005237328A (ja) | 2005-09-08 |
| JP2005237328A5 true JP2005237328A5 (enExample) | 2006-10-12 |
| JP3976742B2 JP3976742B2 (ja) | 2007-09-19 |
Family
ID=34908763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004053795A Expired - Lifetime JP3976742B2 (ja) | 2004-02-27 | 2004-02-27 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US7718623B2 (enExample) |
| JP (1) | JP3976742B2 (enExample) |
| WO (1) | WO2005083076A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4817599B2 (ja) * | 2003-12-25 | 2011-11-16 | 独立行政法人科学技術振興機構 | 免疫活性増強剤とこれを用いた免疫活性の増強方法 |
| AU2007268534B2 (en) * | 2006-05-31 | 2011-07-14 | Osaka University | Immunostimulatory oligonucleotide and pharmaceutical application thereof |
| JP5280432B2 (ja) * | 2007-04-27 | 2013-09-04 | ヒュンジン ヤン | 比重の増加した細胞培養用支持体及びその製造方法 |
| JP5359883B2 (ja) * | 2007-11-28 | 2013-12-04 | 東レ株式会社 | 肝炎の治療剤又は予防剤 |
| WO2009069448A1 (ja) * | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | 日本脳炎ワクチン用のアジュバント及び日本脳炎ワクチン |
| WO2009069447A1 (ja) * | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | インフルエンザワクチン用のアジュバント及びインフルエンザワクチン |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| GB201021867D0 (en) * | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
| JP5906019B2 (ja) * | 2011-03-31 | 2016-04-20 | 国立大学法人福井大学 | 免疫刺激ｇ９．１の抗結核ブースターワクチン創出への応用 |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| US20140086849A1 (en) * | 2012-09-21 | 2014-03-27 | Elizabeth McKenna | Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof |
| AU2013209887B2 (en) | 2012-01-16 | 2021-02-18 | Elizabeth Mckenna | Compositions and methods for the treatment of hepatic diseases and disorders |
| US12268718B2 (en) | 2012-01-16 | 2025-04-08 | Labyrinth Holdings Llc | Control of cellular redox levels |
| AR091569A1 (es) * | 2012-06-28 | 2015-02-11 | Intervet Int Bv | Receptores de tipo toll |
| JP6246121B2 (ja) * | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN112007045B (zh) | 2012-07-13 | 2026-01-06 | 波涛生命科学有限公司 | 手性控制 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| WO2023049275A2 (en) * | 2021-09-23 | 2023-03-30 | Arnay Sciences, Llc | Cyclic structured oligonucleotides as therapeutic agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468520A3 (en) * | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| WO1998055495A2 (en) | 1997-06-06 | 1998-12-10 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| US6218371B1 (en) | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| NZ517928A (en) | 1999-09-27 | 2004-09-24 | Coley Pharm Gmbh | Methods related to immunostimulatory nucleic acid-induced interferon |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| WO2002002172A1 (en) * | 2000-06-30 | 2002-01-10 | Univ Jefferson | Dna palindrome - oligoguanylic acid compositions and uses thereof |
| US20030050268A1 (en) * | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
| CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| EP1450856B1 (en) | 2001-09-14 | 2009-11-11 | Cytos Biotechnology AG | Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use |
| BR0311995A (pt) | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
-
2004
- 2004-02-27 JP JP2004053795A patent/JP3976742B2/ja not_active Expired - Lifetime
-
2005
- 2005-02-25 WO PCT/JP2005/003693 patent/WO2005083076A1/ja not_active Ceased
- 2005-02-25 US US10/590,761 patent/US7718623B2/en not_active Expired - Lifetime