JP2004536788A5 - - Google Patents
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- Publication number
- JP2004536788A5 JP2004536788A5 JP2002571493A JP2002571493A JP2004536788A5 JP 2004536788 A5 JP2004536788 A5 JP 2004536788A5 JP 2002571493 A JP2002571493 A JP 2002571493A JP 2002571493 A JP2002571493 A JP 2002571493A JP 2004536788 A5 JP2004536788 A5 JP 2004536788A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- compound
- pharmaceutically acceptable
- aryl
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000000651 prodrug Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 5
- 125000005556 thienylene group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000005841 biaryl group Chemical group 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims 3
- 102100027995 Collagenase 3 Human genes 0.000 claims 2
- 108050005238 Collagenase 3 Proteins 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000005557 thiazolylene group Chemical group 0.000 claims 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- -1 hydrogen compound Chemical class 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 150000003460 sulfonic acids Chemical class 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27581901P | 2001-03-14 | 2001-03-14 | |
| US27857201P | 2001-03-22 | 2001-03-22 | |
| PCT/EP2002/002808 WO2002072577A2 (en) | 2001-03-14 | 2002-03-13 | Azacycloalkyl substituted acetic acid derivatives for use as mmp inhibitors. |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009014415A Division JP2009137997A (ja) | 2001-03-14 | 2009-01-26 | Ｍｍｐ阻害剤として使用するためのアザシクロアルキル置換酢酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536788A JP2004536788A (ja) | 2004-12-09 |
| JP2004536788A5 true JP2004536788A5 (enExample) | 2005-12-22 |
| JP4294321B2 JP4294321B2 (ja) | 2009-07-08 |
Family
ID=26957610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571493A Expired - Fee Related JP4294321B2 (ja) | 2001-03-14 | 2002-03-13 | Ｍｍｐ阻害剤としての使用のためのアザシクロアルキル置換酢酸誘導体 |
| JP2009014415A Pending JP2009137997A (ja) | 2001-03-14 | 2009-01-26 | Ｍｍｐ阻害剤として使用するためのアザシクロアルキル置換酢酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009014415A Pending JP2009137997A (ja) | 2001-03-14 | 2009-01-26 | Ｍｍｐ阻害剤として使用するためのアザシクロアルキル置換酢酸誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040235896A1 (enExample) |
| EP (1) | EP1373262B1 (enExample) |
| JP (2) | JP4294321B2 (enExample) |
| AT (1) | ATE467629T1 (enExample) |
| AU (1) | AU2002256672A1 (enExample) |
| CA (1) | CA2440419C (enExample) |
| DE (1) | DE60236350D1 (enExample) |
| ES (1) | ES2345977T3 (enExample) |
| PT (1) | PT1373262E (enExample) |
| WO (1) | WO2002072577A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670477B2 (en) * | 2001-03-14 | 2003-12-30 | Novartis Ag | Synthesis of enantiomerically enriched 4-piperidinylglycine |
| JP4219810B2 (ja) * | 2001-10-26 | 2009-02-04 | 塩野義製薬株式会社 | Ｍｍｐ阻害作用を有するスルホンアミド誘導体 |
| AU2003239599B8 (en) | 2002-05-29 | 2008-08-14 | Merck Sharp & Dohme Corp. | Compounds useful in the treatment of anthrax and inhibiting lethal factor |
| JP2007537256A (ja) | 2004-05-11 | 2007-12-20 | メルク エンド カムパニー インコーポレーテッド | Ｎ−スルホン化アミノ酸誘導体調製のためのプロセス |
| US20080119513A1 (en) * | 2004-09-06 | 2008-05-22 | Fumihiko Watanabe | Sulfonamide Derivative Selectively Inhibiting Mmp-13 |
| CN101404987A (zh) * | 2006-01-20 | 2009-04-08 | 史密丝克莱恩比彻姆公司 | 磺酰胺衍生物在治疗代射和神经系统疾病中的用途 |
| US11207312B2 (en) | 2017-07-17 | 2021-12-28 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| PT766664E (pt) * | 1994-06-22 | 2000-08-31 | British Biotech Pharm | Inibidores de metaloproteinases |
| US5817822A (en) * | 1994-06-24 | 1998-10-06 | Novartis Corporation | Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids |
| US6124333A (en) * | 1995-06-22 | 2000-09-26 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| CN100413859C (zh) * | 1996-01-23 | 2008-08-27 | 盐野义制药株式会社 | 磺化的氨基酸衍生物及含有它的金属蛋白酶抑制剂 |
| AU7294098A (en) * | 1997-05-09 | 1998-11-27 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| PT877019E (pt) * | 1997-05-09 | 2002-05-31 | Hoechst Ag | Acidos diaminocarboxilicos substituidos |
| BR9810841A (pt) * | 1997-07-31 | 2001-07-10 | Procter & Gamble | Inibidores de metaloprotease alicìclicos |
| DK0895988T3 (da) * | 1997-08-08 | 2002-09-09 | Pfizer Prod Inc | Arylsulfonylaminohydroxamsyrederivater |
| DE69822839T2 (de) * | 1997-08-08 | 2004-08-19 | Pfizer Products Inc., Groton | Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren |
| SK13352002A3 (sk) * | 2000-03-21 | 2003-05-02 | The Procter & Gamble Company | Metaloproteázové inhibítory s vedľajším heterocyklickým reťazcom |
| SK12842002A3 (sk) * | 2000-03-21 | 2003-02-04 | The Procter And Gamble Company | Heterocyklický vedľajší reťazec obsahujúci N-substituované inhibítory metaloproteáz a farmaceutický prípravok s ich obsahom |
| JP4292321B2 (ja) * | 2001-12-07 | 2009-07-08 | 内山工業株式会社 | ガスケット |
-
2002
- 2002-03-13 CA CA2440419A patent/CA2440419C/en not_active Expired - Fee Related
- 2002-03-13 ES ES02726168T patent/ES2345977T3/es not_active Expired - Lifetime
- 2002-03-13 EP EP02726168A patent/EP1373262B1/en not_active Expired - Lifetime
- 2002-03-13 AU AU2002256672A patent/AU2002256672A1/en not_active Abandoned
- 2002-03-13 DE DE60236350T patent/DE60236350D1/de not_active Expired - Lifetime
- 2002-03-13 PT PT02726168T patent/PT1373262E/pt unknown
- 2002-03-13 WO PCT/EP2002/002808 patent/WO2002072577A2/en not_active Ceased
- 2002-03-13 US US10/471,245 patent/US20040235896A1/en not_active Abandoned
- 2002-03-13 JP JP2002571493A patent/JP4294321B2/ja not_active Expired - Fee Related
- 2002-03-13 AT AT02726168T patent/ATE467629T1/de active
-
2006
- 2006-11-02 US US11/591,861 patent/US20070060569A1/en not_active Abandoned
-
2009
- 2009-01-26 JP JP2009014415A patent/JP2009137997A/ja active Pending
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