JP2004536585A - トル/インターロイキン−1受容体アダプタータンパク質(tirap) - Google Patents

トル/インターロイキン−1受容体アダプタータンパク質(tirap) Download PDF

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Publication number
JP2004536585A
JP2004536585A JP2002587582A JP2002587582A JP2004536585A JP 2004536585 A JP2004536585 A JP 2004536585A JP 2002587582 A JP2002587582 A JP 2002587582A JP 2002587582 A JP2002587582 A JP 2002587582A JP 2004536585 A JP2004536585 A JP 2004536585A
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JP
Japan
Prior art keywords
tirap
polypeptide
seq
tlr4
polynucleotide
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JP2002587582A
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Japanese (ja)
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JP2004536585A5 (cg-RX-API-DMAC7.html
Inventor
メドツィトフ,ルスラン
ホーング,ティファニー
バートン,グレゴリー
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Yale University
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Yale University
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002587582A 2001-05-09 2002-05-09 トル/インターロイキン−1受容体アダプタータンパク質(tirap) Pending JP2004536585A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28981501P 2001-05-09 2001-05-09
US28973801P 2001-05-09 2001-05-09
US28986601P 2001-08-29 2001-08-29
US10139802A 2002-03-19 2002-03-19
PCT/US2002/014915 WO2002090520A2 (en) 2001-05-09 2002-05-09 Toll/interleukin-1 receptor adaptor protein (tirap)

Publications (2)

Publication Number Publication Date
JP2004536585A true JP2004536585A (ja) 2004-12-09
JP2004536585A5 JP2004536585A5 (cg-RX-API-DMAC7.html) 2005-12-22

Family

ID=27493201

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002587582A Pending JP2004536585A (ja) 2001-05-09 2002-05-09 トル/インターロイキン−1受容体アダプタータンパク質(tirap)

Country Status (6)

Country Link
US (3) US6960343B2 (cg-RX-API-DMAC7.html)
EP (1) EP1401281A4 (cg-RX-API-DMAC7.html)
JP (1) JP2004536585A (cg-RX-API-DMAC7.html)
AU (1) AU2002305539A1 (cg-RX-API-DMAC7.html)
CA (1) CA2446458A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002090520A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017002057A (ja) * 2007-07-26 2017-01-05 ルバンス セラピュティックス インク.Revance Therapeutics,Inc. 抗菌ペプチド、組成物及びその使用方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
AU2002216245A1 (en) * 2000-12-22 2002-07-08 Synovis Limited Methods of modulating toll-related receptor (trr) signaling
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
JP2004073073A (ja) * 2002-08-16 2004-03-11 Japan Science & Technology Corp エンドトキシン及びリポタンパク・リポペプチド不応答性モデル非ヒト動物
JP2006523452A (ja) * 2003-03-25 2006-10-19 スリーエム イノベイティブ プロパティズ カンパニー 共通のToll様受容体を通じて媒介される細胞活性の選択的活性化
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
US20060002941A1 (en) * 2004-01-23 2006-01-05 Vievax Corp. Compositions comprising immune response altering agents and methods of use
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
BRPI0519148A2 (pt) 2004-12-20 2008-12-30 Sigma Tau Ind Farmaceuti inibidores de homodimerizaÇço de myd88
KR101415864B1 (ko) * 2005-01-28 2014-07-09 갈렌바이오 인코포레이티드 면역학적 활성 조성물
US20100069297A1 (en) * 2005-04-15 2010-03-18 Mathew J Fenton Selective Inhibition of TLR4 Signaling
JP2011525477A (ja) * 2008-03-04 2011-09-22 リクイディア・テクノロジーズ・インコーポレーテッド 免疫調節剤粒子および処置方法
EP2625196B1 (en) 2010-10-05 2016-03-23 Kemijski Institut Fusion polypeptides comprising tir and dimerization domain for modulation of tlr/innate immunity signaling
KR101566107B1 (ko) 2014-04-18 2015-11-05 영남대학교 산학협력단 Tlr6 tir 도메인의 3차 구조 및 이를 이용한 약물 스크리닝 방법
DK3259597T3 (da) 2015-02-19 2022-05-09 Compugen Ltd Pvrig-polypeptider og fremgangsmåder til behandling
RU2732042C2 (ru) 2015-02-19 2020-09-10 Компьюджен Лтд. Анти-pvrig антитела и способы применения
EP3095444A1 (en) 2015-05-20 2016-11-23 Dublin City University A method of treating peripheral inflammatory disease
WO2018220446A1 (en) 2017-06-01 2018-12-06 Compugen Ltd. Triple combination antibody therapies
KR20200084569A (ko) * 2019-01-03 2020-07-13 주식회사 젠센 Tlr4 신호전달 경로를 억제하는 펩타이드 및 그 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060080A2 (en) * 1999-04-05 2000-10-12 Incyte Pharmaceuticals, Inc. Molecules of the immune system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271349B1 (en) * 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6399584B1 (en) * 1998-03-18 2002-06-04 Institute Curie Pharmaceutical composition containing ezrin mutated on tyrosine 353
US7029861B1 (en) * 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
DE60042986D1 (de) * 1999-01-14 2009-10-29 Japan Science & Tech Agency MyoD-knockout Maus als Bakterienzellwandbestandteil-unansprechender Tiermodell
US6506769B2 (en) * 1999-10-06 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic compounds useful as inhibitors of tyrosine kinases
WO2001088137A2 (en) * 2000-05-17 2001-11-22 Immunex Corporation Human myd88 adapter-like protein and functional fragments thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060080A2 (en) * 1999-04-05 2000-10-12 Incyte Pharmaceuticals, Inc. Molecules of the immune system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017002057A (ja) * 2007-07-26 2017-01-05 ルバンス セラピュティックス インク.Revance Therapeutics,Inc. 抗菌ペプチド、組成物及びその使用方法

Also Published As

Publication number Publication date
AU2002305539A1 (en) 2002-11-18
WO2002090520A3 (en) 2003-07-10
US7285535B2 (en) 2007-10-23
CA2446458A1 (en) 2002-11-14
US20060130164A1 (en) 2006-06-15
US20080096250A1 (en) 2008-04-24
US20030023993A1 (en) 2003-01-30
EP1401281A2 (en) 2004-03-31
EP1401281A4 (en) 2004-12-29
US6960343B2 (en) 2005-11-01
WO2002090520A2 (en) 2002-11-14

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