JP2004534847A5 - - Google Patents
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- JP2004534847A5 JP2004534847A5 JP2003512201A JP2003512201A JP2004534847A5 JP 2004534847 A5 JP2004534847 A5 JP 2004534847A5 JP 2003512201 A JP2003512201 A JP 2003512201A JP 2003512201 A JP2003512201 A JP 2003512201A JP 2004534847 A5 JP2004534847 A5 JP 2004534847A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- alkyl group
- aliphatic
- aliphatic group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000001931 aliphatic group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 239000007858 starting material Substances 0.000 claims 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Carbodicyclohexylimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 2
- QRXWMOHMRWLFEY-UHFFFAOYSA-N Isoniazid Chemical group NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 2
- CFHGBZLNZZVTAY-UHFFFAOYSA-N Lawesson's reagent Chemical group C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- CYQAYERJWZKYML-UHFFFAOYSA-N Phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 claims 1
- 230000002862 amidating Effects 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30431801P | 2001-07-10 | 2001-07-10 | |
| PCT/US2002/021716 WO2003006429A1 (en) | 2001-07-10 | 2002-07-10 | Synthesis of taxol enhancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534847A JP2004534847A (ja) | 2004-11-18 |
| JP2004534847A5 true JP2004534847A5 (US07652168-20100126-C00055.png) | 2006-01-05 |
Family
ID=23176001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003512201A Pending JP2004534847A (ja) | 2001-07-10 | 2002-07-10 | タキソール増強剤の合成 |
Country Status (11)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI330079B (en) * | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| CN1993318B (zh) | 2004-06-23 | 2012-10-03 | Synta医药公司 | 用于治疗癌症的双（硫代-酰肼酰胺）盐 |
| US20060167106A1 (en) * | 2004-11-19 | 2006-07-27 | Mei Zhang | Compounds acting at the centrosome |
| JP5204489B2 (ja) * | 2004-11-19 | 2013-06-05 | シンタ ファーマスーティカルズ コーポレイション | Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド） |
| WO2006113572A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
| JP2008536875A (ja) | 2005-04-15 | 2008-09-11 | シンタ ファーマシューティカルズ コーポレーション | ビス（チオヒドラジド）アミド化合物による併用癌療法 |
| EP1888520A2 (en) | 2005-05-16 | 2008-02-20 | Synta Pharmaceuticals Corporation | Synthesis of bis(thio-hydrazide amide) salts |
| BRPI0614826A2 (pt) | 2005-08-16 | 2011-04-19 | Synta Pharmaceuticals Corp | composições, método para a preparação de liofilizado de uma composição e liofilizado |
| AU2007288336B2 (en) * | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| AU2007288338B2 (en) | 2006-08-21 | 2012-05-03 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2008024299A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| EP2076254A2 (en) | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
| CN101134057B (zh) * | 2006-09-01 | 2011-04-27 | 中山大学 | 含紫杉醇的天然植物提取物的复方药物及其抗癌应用 |
| WO2008033300A2 (en) * | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| US7645904B2 (en) * | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US20090093538A1 (en) * | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| WO2009064374A2 (en) | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| EP2225201A2 (en) * | 2007-11-28 | 2010-09-08 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
| US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| BRPI0919720A2 (pt) | 2008-10-22 | 2015-12-08 | Synta Pharmaceuticals Corp | complexos de metal de transição de compostos bis-[tio hidrazida amida |
| EP2373624A4 (en) | 2008-10-22 | 2014-06-11 | Synta Pharmaceuticals Corp | TRANSITION METAL COMPLEXES OF A TO [THIOHYDRAZIDAMID] COMPOUND |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| WO2010065512A2 (en) | 2008-12-01 | 2010-06-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| JP2014534238A (ja) | 2011-11-10 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与 |
| WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
| WO2013144228A1 (en) | 2012-03-29 | 2013-10-03 | Basf Se | Pesticidal methods using heterocyclic compounds and derivatives for combating animal pests |
| CN115572249A (zh) * | 2022-09-21 | 2023-01-06 | 南京红云生物科技有限公司上海分公司 | 一种铜离子螯合剂及其制备方法 |
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| JPS5091056A (US07652168-20100126-C00055.png) | 1973-12-17 | 1975-07-21 | ||
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| TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| MXPA02010231A (es) | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
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| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| AU2006228035B2 (en) | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
| NZ541479A (en) | 2003-02-11 | 2008-11-28 | Vernalis Cambridge Liimited | Isoxazole compounds as inhibitors of heat shock proteins |
| KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | ｐ38／ＪＴＶ－1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
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| CN1993318B (zh) | 2004-06-23 | 2012-10-03 | Synta医药公司 | 用于治疗癌症的双（硫代-酰肼酰胺）盐 |
| US20060142393A1 (en) | 2004-09-16 | 2006-06-29 | Sherman Matthew L | Bis(thio-hydrazide amides) for treatment of hyperplasia |
| JP5204489B2 (ja) | 2004-11-19 | 2013-06-05 | シンタ ファーマスーティカルズ コーポレイション | Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド） |
| US20060167106A1 (en) | 2004-11-19 | 2006-07-27 | Mei Zhang | Compounds acting at the centrosome |
| MX2007009888A (es) | 2005-02-17 | 2007-10-16 | Synta Pharmaceuticals Corp | Compuestos para el tratamiento de trastornos proliferativos. |
| JP2008536875A (ja) | 2005-04-15 | 2008-09-11 | シンタ ファーマシューティカルズ コーポレーション | ビス（チオヒドラジド）アミド化合物による併用癌療法 |
| WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| WO2006113572A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
| EP1888520A2 (en) | 2005-05-16 | 2008-02-20 | Synta Pharmaceuticals Corporation | Synthesis of bis(thio-hydrazide amide) salts |
| BRPI0614826A2 (pt) | 2005-08-16 | 2011-04-19 | Synta Pharmaceuticals Corp | composições, método para a preparação de liofilizado de uma composição e liofilizado |
| SI22254A (sl) | 2006-04-13 | 2007-10-31 | Univerza V Ljubljani Fakulteta Za Farmacijo | NOVI ARILSULFONOHIDRAZIDNI INHIBITORJI ENCIMOV MurC IN MurD |
| AU2007288336B2 (en) | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| WO2008024299A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
| AU2007288340A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| AU2007288338B2 (en) | 2006-08-21 | 2012-05-03 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| JP2010501560A (ja) | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 増殖性障害を治療するための化合物 |
| EP2076254A2 (en) | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
| WO2008033300A2 (en) | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
| EP2059250A2 (en) | 2006-09-14 | 2009-05-20 | Synta Pharmaceuticals Corporation | Compounds for the treatment of angiogenesis |
| US7645904B2 (en) | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US20090093538A1 (en) | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| US8093425B2 (en) | 2007-04-30 | 2012-01-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2009064374A2 (en) | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| TW200940050A (en) * | 2007-11-28 | 2009-10-01 | Synta Pharmaceuticals Corp | Polymorphs of N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide) |
| EP2225201A2 (en) | 2007-11-28 | 2010-09-08 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
-
2002
- 2002-07-09 TW TW091115205A patent/TWI252847B/zh not_active IP Right Cessation
- 2002-07-10 EP EP02746946A patent/EP1406868A1/en not_active Ceased
- 2002-07-10 KR KR10-2004-7000333A patent/KR20040026679A/ko not_active Application Discontinuation
- 2002-07-10 CN CNB02817724XA patent/CN100398516C/zh not_active Expired - Fee Related
- 2002-07-10 CA CA002453415A patent/CA2453415A1/en not_active Abandoned
- 2002-07-10 US US10/193,076 patent/US6825235B2/en not_active Expired - Fee Related
- 2002-07-10 AU AU2002316625A patent/AU2002316625B2/en not_active Ceased
- 2002-07-10 MX MXPA04000245A patent/MXPA04000245A/es not_active Application Discontinuation
- 2002-07-10 CN CNA2008100928683A patent/CN101270069A/zh active Pending
- 2002-07-10 WO PCT/US2002/021716 patent/WO2003006429A1/en active Application Filing
- 2002-07-10 JP JP2003512201A patent/JP2004534847A/ja active Pending
-
2004
- 2004-01-07 NO NO20040053A patent/NO20040053L/no not_active Application Discontinuation
- 2004-03-24 US US10/807,919 patent/US7074952B2/en not_active Expired - Fee Related
-
2006
- 2006-05-24 US US11/440,429 patent/US7435843B2/en not_active Expired - Fee Related
- 2006-08-24 AU AU2006203689A patent/AU2006203689A1/en not_active Abandoned
-
2008
- 2008-08-29 US US12/231,217 patent/US7652168B2/en not_active Expired - Fee Related
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