JP2004534025A5 - - Google Patents
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- JP2004534025A5 JP2004534025A5 JP2002586930A JP2002586930A JP2004534025A5 JP 2004534025 A5 JP2004534025 A5 JP 2004534025A5 JP 2002586930 A JP2002586930 A JP 2002586930A JP 2002586930 A JP2002586930 A JP 2002586930A JP 2004534025 A5 JP2004534025 A5 JP 2004534025A5
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- Prior art keywords
- pharmaceutical composition
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- amino acid
- tumor
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- 239000008194 pharmaceutical composition Substances 0.000 claims 157
- 150000001875 compounds Chemical class 0.000 claims 56
- 206010028980 Neoplasm Diseases 0.000 claims 32
- 125000000539 amino acid group Chemical group 0.000 claims 32
- 210000004027 cell Anatomy 0.000 claims 31
- 150000003839 salts Chemical group 0.000 claims 21
- PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 claims 16
- 239000003112 inhibitor Substances 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 14
- ORQFDHFZSMXRLM-UHFFFAOYSA-N 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene Chemical compound C1=C(OC)C(OC)=CC=C1CC(C)C(C)CC1=CC=C(OC)C(OC)=C1 ORQFDHFZSMXRLM-UHFFFAOYSA-N 0.000 claims 13
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- 102000000763 Survivin Human genes 0.000 claims 9
- 108010002687 Survivin Proteins 0.000 claims 9
- HCZKYJDFEPMADG-UHFFFAOYSA-N nordihydroguaiaretic acid Chemical compound C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 4
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- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims 4
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- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 3
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 3
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- 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 claims 2
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/851,425 US6608108B2 (en) | 1999-10-15 | 2001-05-09 | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
| PCT/US2002/014374 WO2002089795A1 (en) | 2001-05-09 | 2002-05-08 | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009177106A Division JP2009242438A (ja) | 2001-05-09 | 2009-07-29 | ノルジヒドログアヤレティク酸誘導体を使用して腫瘍を処置するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534025A JP2004534025A (ja) | 2004-11-11 |
| JP2004534025A5 true JP2004534025A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002586930A Pending JP2004534025A (ja) | 2001-05-09 | 2002-05-08 | ノルジヒドログアヤレティク酸誘導体を使用して腫瘍を処置するための方法 |
| JP2009177106A Pending JP2009242438A (ja) | 2001-05-09 | 2009-07-29 | ノルジヒドログアヤレティク酸誘導体を使用して腫瘍を処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009177106A Pending JP2009242438A (ja) | 2001-05-09 | 2009-07-29 | ノルジヒドログアヤレティク酸誘導体を使用して腫瘍を処置するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6608108B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1392293B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2004534025A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1525857B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002311890C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2447045A1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG169224A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002089795A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365787B1 (en) * | 1994-09-30 | 2002-04-02 | The Johns Hopkins University | Compounds for the suppression of HIV TAT transactivation |
| US6608108B2 (en) * | 1999-10-15 | 2003-08-19 | Johns Hopkins University | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
| US7728036B2 (en) | 2003-05-20 | 2010-06-01 | Erimos Pharmaceuticals, Llc | Methods for delivery of catecholic butanes for treatment of tumors |
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| US8440648B2 (en) * | 2004-07-20 | 2013-05-14 | Erimos Pharmaceuticals Llc | Methods and compositions for treatment of intraepithelial neoplasia |
| CA2589762A1 (en) * | 2004-12-22 | 2006-06-29 | The Gillette Company | Reduction of hair growth with survivin inhibitors |
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| CN101150955B (zh) * | 2005-01-27 | 2013-04-17 | 埃里莫斯医药品有限公司 | 递送包括ndga化合物的儿茶酚丁烷的口服制剂 |
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| US8367126B2 (en) | 2005-09-27 | 2013-02-05 | University Of Kentucky Research Foundation | Berry preparations and extracts |
| CA2622286A1 (en) * | 2005-09-27 | 2007-04-05 | University Of Kentucky Research Foundation | Anti-inflammatory composition comprising berry extract |
| US20090155349A1 (en) * | 2006-02-23 | 2009-06-18 | Jonathan Daniel Heller | Methods of treating influenza viral infections |
| WO2008027037A1 (en) * | 2006-08-29 | 2008-03-06 | University Of Kentucky Research Foundation | Compositions and methods for oral cancer chemoprevention using berry preparations and extracts |
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| US20120171213A1 (en) | 2009-09-10 | 2012-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| WO2012106556A2 (en) | 2011-02-02 | 2012-08-09 | Amgen Inc. | Methods and compositons relating to inhibition of igf-1r |
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| US10342767B2 (en) | 2011-04-21 | 2019-07-09 | Children's Hospital Medical Center | Therapy for kinase-dependent malignancies |
| CA2852127C (en) | 2011-11-11 | 2020-10-27 | Duke University | Combination drug therapy for the treatment of solid tumors |
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| CA2938626A1 (en) | 2013-07-26 | 2015-01-29 | John Rothman | Compositions to improve the therapeutic benefit of bisantrene |
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| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
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| US6608108B2 (en) * | 1999-10-15 | 2003-08-19 | Johns Hopkins University | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
-
2001
- 2001-05-09 US US09/851,425 patent/US6608108B2/en not_active Expired - Lifetime
-
2002
- 2002-05-08 CN CN028138627A patent/CN1525857B/zh not_active Expired - Lifetime
- 2002-05-08 SG SG200507965-2A patent/SG169224A1/en unknown
- 2002-05-08 AU AU2002311890A patent/AU2002311890C1/en not_active Ceased
- 2002-05-08 CA CA002447045A patent/CA2447045A1/en not_active Withdrawn
- 2002-05-08 JP JP2002586930A patent/JP2004534025A/ja active Pending
- 2002-05-08 EP EP02739227.3A patent/EP1392293B1/en not_active Expired - Lifetime
- 2002-05-08 WO PCT/US2002/014374 patent/WO2002089795A1/en not_active Ceased
- 2002-10-15 US US10/270,313 patent/US6777444B2/en not_active Expired - Lifetime
-
2003
- 2003-12-16 US US10/735,910 patent/US8318815B2/en not_active Expired - Fee Related
-
2009
- 2009-07-29 JP JP2009177106A patent/JP2009242438A/ja active Pending
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