JP2004533991A5 - - Google Patents
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- Publication number
- JP2004533991A5 JP2004533991A5 JP2002558387A JP2002558387A JP2004533991A5 JP 2004533991 A5 JP2004533991 A5 JP 2004533991A5 JP 2002558387 A JP2002558387 A JP 2002558387A JP 2002558387 A JP2002558387 A JP 2002558387A JP 2004533991 A5 JP2004533991 A5 JP 2004533991A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hcv
- peptide
- epitope
- cell line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 210000004027 cell Anatomy 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 16
- 241000711549 Hepacivirus C Species 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 10
- 101710125507 Integrase/recombinase Proteins 0.000 claims 8
- 229960005486 vaccine Drugs 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 102000007079 Peptide Fragments Human genes 0.000 claims 4
- 108010033276 Peptide Fragments Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 108700008783 Hepatitis C virus E1 Proteins 0.000 claims 3
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102100027221 CD81 antigen Human genes 0.000 claims 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001875 compounds Chemical group 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 150000002484 inorganic compounds Chemical group 0.000 claims 1
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 150000002894 organic compounds Chemical group 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/728,720 US7091324B2 (en) | 1998-11-05 | 2000-12-01 | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| PCT/US2001/045029 WO2002057314A2 (en) | 2000-12-01 | 2001-11-30 | Prevention and treatment of hcv infection employing antibodies directed against conformational epitopes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004533991A JP2004533991A (ja) | 2004-11-11 |
| JP2004533991A5 true JP2004533991A5 (https=) | 2005-12-22 |
Family
ID=24928023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002558387A Pending JP2004533991A (ja) | 2000-12-01 | 2001-11-30 | コンホメーションエピトープを利用するｈｃｖ感染の予防及び治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7091324B2 (https=) |
| EP (1) | EP1409682A2 (https=) |
| JP (1) | JP2004533991A (https=) |
| AU (1) | AU2002246545A1 (https=) |
| CA (1) | CA2437082A1 (https=) |
| WO (1) | WO2002057314A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060188511A1 (en) * | 1998-11-05 | 2006-08-24 | Foung Steven K | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
| IL137522A (en) * | 2000-07-26 | 2007-06-17 | Drk Blutspendediendst Baden Wu | Human monoclonal antibody against hepatitis c virus e2 glycoprotein |
| ATE425187T1 (de) | 2001-01-12 | 2009-03-15 | Molecules Of Man Ab | Materialien und methoden zur behandlung von hepatitis c |
| US7326536B2 (en) * | 2001-05-03 | 2008-02-05 | Eli Lilly And Company | Agents for treatment of HCV and methods of use |
| ITRM20020049A1 (it) * | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| FR2850384A1 (fr) * | 2003-01-28 | 2004-07-30 | Centre Nat Rech Scient | Antigenes mimant les domaines extracellulaires de proteines membranaires de type iii issues de microorganismes intracellulaires pathogenes, anticorps conformationnels derives, et leurs applications |
| EP1608683B1 (en) | 2003-04-01 | 2011-11-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antibodies directed against hepatitis c virus e1e2 complex and pharmaceutical compositions |
| ATE474587T1 (de) * | 2004-09-29 | 2010-08-15 | Univ Tulane | Inhibitoren des hepatitis-c-virus |
| EP1669368A1 (en) * | 2004-12-13 | 2006-06-14 | Genoscience | Use of peptides from the E2 protein of HCV for treating HCV infection |
| JP5161882B2 (ja) | 2006-09-07 | 2013-03-13 | クルセル ホランド ベー ヴェー | インフルエンザウイルスｈ５ｎ１を中和しうるヒト結合性分子およびその使用 |
| US7858752B2 (en) | 2006-12-05 | 2010-12-28 | Abbott Laboratories | Recombinant antibodies against hepatitis C virus and methods of obtaining and using same |
| BRPI0823197A2 (pt) | 2008-10-05 | 2015-06-23 | Univ Leland Stanford Junior | Anticorpos contra hepatite c e aplicações dos mesmos |
| US20100322943A1 (en) | 2009-06-17 | 2010-12-23 | Thomas Cantor | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415491A (en) | 1980-01-14 | 1983-11-15 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4683136A (en) | 1985-03-06 | 1987-07-28 | Scripps Clinic And Research Foundation | Proteinaceous antigens with conformation-independent and conformation-dependent determinants |
| EP0299242A3 (en) | 1987-06-22 | 1989-01-25 | Medico Labs Ag | Heterologous viral peptide particle immunogens |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US6027729A (en) | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US5308750A (en) * | 1989-12-22 | 1994-05-03 | Abbott Laboratories | Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same |
| US5106726A (en) | 1990-02-16 | 1992-04-21 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV |
| CA2079912C (en) | 1990-04-06 | 2000-07-11 | Gregory Reyes | Hepatitis c virus epitopes |
| US6274148B1 (en) | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| EP0491077A1 (en) | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
| US5574132A (en) | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
| WO1993006126A1 (en) | 1991-09-13 | 1993-04-01 | Chiron Corporation | Immunoreactive hepatitis c virus polypeptide compositions |
| US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| JPH07299655A (ja) | 1994-04-30 | 1995-11-14 | Aisin Seiki Co Ltd | 内スプライン歯面仕上機 |
| AU3241095A (en) | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| US5985609A (en) | 1994-11-04 | 1999-11-16 | Mogam Biotechnology Research Institute | Process for preparing hepatitis C virus envelope glycoproteins |
| US6020122A (en) | 1995-06-07 | 2000-02-01 | Abbott Laboratories | Hepatitis C virus second envelope (HCV-E2) glycoprotein expression system |
| US6747136B2 (en) * | 1996-04-19 | 2004-06-08 | Karolinska Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| US6538114B1 (en) * | 1996-04-19 | 2003-03-25 | Karolina Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| CA2305715A1 (en) | 1997-11-06 | 1999-05-20 | Innogenetics N.V. | Host derived proteins binding hcv: medical, diagnostic and purification use |
| AU5285899A (en) * | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| WO2000026418A1 (en) | 1998-11-05 | 2000-05-11 | The Board Of Trustees Of Leland Stanford Junior University | Human pan-hcv human monoclonal antibodies |
-
2000
- 2000-12-01 US US09/728,720 patent/US7091324B2/en not_active Expired - Fee Related
-
2001
- 2001-11-30 WO PCT/US2001/045029 patent/WO2002057314A2/en not_active Ceased
- 2001-11-30 EP EP01994118A patent/EP1409682A2/en not_active Ceased
- 2001-11-30 JP JP2002558387A patent/JP2004533991A/ja active Pending
- 2001-11-30 AU AU2002246545A patent/AU2002246545A1/en not_active Abandoned
- 2001-11-30 CA CA002437082A patent/CA2437082A1/en not_active Abandoned
-
2006
- 2006-08-15 US US11/504,974 patent/US20070032635A1/en not_active Abandoned
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