JP2004533421A5 - - Google Patents

Info

Publication number

JP2004533421A5

JP2004533421A5 JP2002574998A JP2002574998A JP2004533421A5 JP 2004533421 A5 JP2004533421 A5 JP 2004533421A5 JP 2002574998 A JP2002574998 A JP 2002574998A JP 2002574998 A JP2002574998 A JP 2002574998A JP 2004533421 A5 JP2004533421 A5 JP 2004533421A5

Authority

JP

Japan

Prior art keywords

monolipopeptide

peptide

composition according

amino acids

lipid

Prior art date

2002-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 16
• 150000001413 amino acids Chemical class 0.000 claims 12
• 230000002163 immunogen Effects 0.000 claims 11
• 150000002632 lipids Chemical class 0.000 claims 9
• 239000002502 liposome Substances 0.000 claims 7
• 230000008020 evaporation Effects 0.000 claims 3
• 238000001704 evaporation Methods 0.000 claims 3
• 239000000232 Lipid Bilayer Substances 0.000 claims 2
• 239000002671 adjuvant Substances 0.000 claims 2
• 208000002672 hepatitis B Diseases 0.000 claims 2
• 201000004792 malaria Diseases 0.000 claims 2
• 201000008827 tuberculosis Diseases 0.000 claims 2
• 229960005486 vaccine Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000001125 extrusion Methods 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 1
• 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 102000027450 oncoproteins Human genes 0.000 claims 1
• 108091008819 oncoproteins Proteins 0.000 claims 1
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 239000002691 unilamellar liposome Substances 0.000 claims 1