JP2004532896A5 - - Google Patents

Info

Publication number

JP2004532896A5

JP2004532896A5 JP2003507548A JP2003507548A JP2004532896A5 JP 2004532896 A5 JP2004532896 A5 JP 2004532896A5 JP 2003507548 A JP2003507548 A JP 2003507548A JP 2003507548 A JP2003507548 A JP 2003507548A JP 2004532896 A5 JP2004532896 A5 JP 2004532896A5

Authority

JP

Japan

Prior art keywords

leu

compound

group

val

seq

Prior art date

2002-06-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 42
• 238000000034 method Methods 0.000 claims 34
• 210000001744 T-lymphocyte Anatomy 0.000 claims 12
• 150000001413 amino acids Chemical class 0.000 claims 12
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 10
• 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 8
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 8
• 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 6
• 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 6
• 230000002163 immunogen Effects 0.000 claims 6
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
• 241001465754 Metazoa Species 0.000 claims 5
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 3
• 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 3
• 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 3
• PLOPBXQQPZYQFA-AXPWDRQUSA-N amlintide Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CSSC1)[C@@H](C)O)C(C)C)C1=CC=CC=C1 PLOPBXQQPZYQFA-AXPWDRQUSA-N 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 241000024188 Andala Species 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 210000004698 lymphocyte Anatomy 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 101100514845 Arabidopsis thaliana MTV1 gene Proteins 0.000 claims 1
• 229940126062 Compound A Drugs 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• 241000283984 Rodentia Species 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 238000010171 animal model Methods 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• 210000004153 islets of langerhan Anatomy 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000007170 pathology Effects 0.000 claims 1
• 210000005259 peripheral blood Anatomy 0.000 claims 1
• 239000011886 peripheral blood Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 210000004989 spleen cell Anatomy 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1