JP2004532849A - 中枢神経系へのポリヌクレオチド薬剤の送達 - Google Patents
中枢神経系へのポリヌクレオチド薬剤の送達 Download PDFInfo
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- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28531901P | 2001-04-20 | 2001-04-20 | |
| US28871601P | 2001-05-04 | 2001-05-04 | |
| PCT/US2002/012527 WO2002086105A1 (en) | 2001-04-20 | 2002-04-19 | Delivery of polynucleotide agents to the central nervous sysstem |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008282272A Division JP2009067805A (ja) | 2001-04-20 | 2008-10-31 | 中枢神経系へのポリヌクレオチド薬剤の送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532849A true JP2004532849A (ja) | 2004-10-28 |
| JP2004532849A5 JP2004532849A5 (enExample) | 2005-12-22 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002583620A Pending JP2004532849A (ja) | 2001-04-20 | 2002-04-19 | 中枢神経系へのポリヌクレオチド薬剤の送達 |
| JP2008282272A Withdrawn JP2009067805A (ja) | 2001-04-20 | 2008-10-31 | 中枢神経系へのポリヌクレオチド薬剤の送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008282272A Withdrawn JP2009067805A (ja) | 2001-04-20 | 2008-10-31 | 中枢神経系へのポリヌクレオチド薬剤の送達 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20030165434A1 (enExample) |
| EP (1) | EP1385937A4 (enExample) |
| JP (2) | JP2004532849A (enExample) |
| WO (1) | WO2002086105A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008545394A (ja) * | 2005-05-18 | 2008-12-18 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 生存細胞中でのリアルタイム核酸分析のための組成物、方法およびキット |
| JP2015510889A (ja) * | 2012-03-09 | 2015-04-13 | ノースイースタン・ユニバーシティ | 中枢神経系障害を治療するための核酸ナノ粒子を中枢神経系へ送達する方法 |
| WO2023243606A1 (ja) * | 2022-06-13 | 2023-12-21 | 国立大学法人 東京大学 | 核酸とカチオン性ポリマーとのポリイオンコンプレックスであって、正の表面電位を有し、核酸を脳組織に送達することができるポリイオンコンプレックス |
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| EP1423537A4 (en) * | 2001-08-07 | 2006-11-29 | Univ Delaware | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING HUNTINGTON'S DISEASE |
| US20040096880A1 (en) * | 2001-08-07 | 2004-05-20 | Kmiec Eric B. | Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation |
| CA2515484C (en) | 2003-02-11 | 2011-09-20 | Antisense Therapeutics Ltd | Modulation of insulin like growth factor i receptor expression |
| US20050271651A1 (en) * | 2004-01-23 | 2005-12-08 | Oklahoma Medical Research Foundation | Inhibition of bright function as a treatment for excessive immunoglobulin production |
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| US7754679B2 (en) * | 2005-11-16 | 2010-07-13 | Idexx Laboratories, Inc. | Pharmaceutical compositions for the administration of aptamers |
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| EP3622821A1 (en) | 2013-05-15 | 2020-03-18 | Regents of the University of Minnesota | Adeno-associated virus mediated gene transfer to the central nervous system |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624898A (en) * | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| US5714170A (en) * | 1994-11-16 | 1998-02-03 | Thomas Jefferson University | Method of inducing resistance to tumor growth |
| US6025193A (en) * | 1996-03-15 | 2000-02-15 | Allegheny University Of The Health Sciences | Methods and compositions for diagnosis and treatment of pathological conditions related to abnormal dopamine receptor expression |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| IL131212A0 (en) * | 1999-08-03 | 2001-01-28 | Yissum Res Dev Co | Recombinant virus and live-virus vaccines |
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2002
- 2002-04-19 WO PCT/US2002/012527 patent/WO2002086105A1/en not_active Ceased
- 2002-04-19 JP JP2002583620A patent/JP2004532849A/ja active Pending
- 2002-04-19 US US10/126,060 patent/US20030165434A1/en not_active Abandoned
- 2002-04-19 EP EP02764268A patent/EP1385937A4/en not_active Withdrawn
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2005
- 2005-12-29 US US11/323,644 patent/US20060216317A1/en not_active Abandoned
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2008
- 2008-10-31 JP JP2008282272A patent/JP2009067805A/ja not_active Withdrawn
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2009
- 2009-04-07 US US12/419,999 patent/US20090264506A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008545394A (ja) * | 2005-05-18 | 2008-12-18 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 生存細胞中でのリアルタイム核酸分析のための組成物、方法およびキット |
| JP2015510889A (ja) * | 2012-03-09 | 2015-04-13 | ノースイースタン・ユニバーシティ | 中枢神経系障害を治療するための核酸ナノ粒子を中枢神経系へ送達する方法 |
| WO2023243606A1 (ja) * | 2022-06-13 | 2023-12-21 | 国立大学法人 東京大学 | 核酸とカチオン性ポリマーとのポリイオンコンプレックスであって、正の表面電位を有し、核酸を脳組織に送達することができるポリイオンコンプレックス |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060216317A1 (en) | 2006-09-28 |
| EP1385937A4 (en) | 2005-11-09 |
| WO2002086105A1 (en) | 2002-10-31 |
| EP1385937A1 (en) | 2004-02-04 |
| US20030165434A1 (en) | 2003-09-04 |
| US20090264506A1 (en) | 2009-10-22 |
| JP2009067805A (ja) | 2009-04-02 |
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