JP2004531530A5 - - Google Patents
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- Publication number
- JP2004531530A5 JP2004531530A5 JP2002582902A JP2002582902A JP2004531530A5 JP 2004531530 A5 JP2004531530 A5 JP 2004531530A5 JP 2002582902 A JP2002582902 A JP 2002582902A JP 2002582902 A JP2002582902 A JP 2002582902A JP 2004531530 A5 JP2004531530 A5 JP 2004531530A5
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- concentrate
- water
- process according
- solubilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 239000012141 concentrate Substances 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 6
- 239000013067 intermediate product Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 4
- 239000000693 micelle Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims 2
- 235000008696 isoflavones Nutrition 0.000 claims 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 2
- 235000020778 linoleic acid Nutrition 0.000 claims 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 2
- 235000012661 lycopene Nutrition 0.000 claims 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims 2
- 229960004999 lycopene Drugs 0.000 claims 2
- 239000001751 lycopene Substances 0.000 claims 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 235000005875 quercetin Nutrition 0.000 claims 2
- 229960001285 quercetin Drugs 0.000 claims 2
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 229940110767 coenzyme Q10 Drugs 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims 1
- 150000002515 isoflavone derivatives Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- -1 phytosterins Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000004550 soluble concentrate Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10109708A DE10109708A1 (de) | 2001-02-11 | 2001-02-11 | Wasserlösliches Wirkstoffkonzentrat |
| DE10108614A DE10108614B4 (de) | 2001-02-22 | 2001-02-22 | Wasserlösliches Konzentrat eines stoffwechselbeeinflussenden Wirkstoffes |
| PCT/EP2002/001416 WO2002085328A2 (de) | 2001-02-11 | 2002-02-11 | Verfahren zur herstellung eines wirkstoffkonzentrats sowie wirkstoffkonzentrat |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006115962A Division JP2006241167A (ja) | 2001-02-11 | 2006-04-19 | 活性物質の濃縮物の製法および活性物質の濃縮物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004531530A JP2004531530A (ja) | 2004-10-14 |
| JP2004531530A5 true JP2004531530A5 (https=) | 2006-06-15 |
Family
ID=26008603
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582902A Pending JP2004531530A (ja) | 2001-02-11 | 2002-02-11 | 活性物質の濃縮物の製法および活性物質の濃縮物 |
| JP2006115962A Pending JP2006241167A (ja) | 2001-02-11 | 2006-04-19 | 活性物質の濃縮物の製法および活性物質の濃縮物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006115962A Pending JP2006241167A (ja) | 2001-02-11 | 2006-04-19 | 活性物質の濃縮物の製法および活性物質の濃縮物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040081670A1 (https=) |
| EP (3) | EP1377273B1 (https=) |
| JP (2) | JP2004531530A (https=) |
| AT (2) | ATE425743T1 (https=) |
| AU (1) | AU2002250914A1 (https=) |
| CA (1) | CA2436273A1 (https=) |
| DE (2) | DE50213362D1 (https=) |
| ES (1) | ES2324400T3 (https=) |
| MX (1) | MXPA03007141A (https=) |
| WO (1) | WO2002085328A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50213362D1 (de) * | 2001-02-11 | 2009-04-30 | Aquanova Ag | Verfahren zur herstellung eines isoflavon-konzentrats |
| JP2005531616A (ja) | 2002-06-29 | 2005-10-20 | アクヴァノヴァ・ジャーマン・ソリュービリセイト・テクノロジーズ・（アーゲーテー）・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | イソフラボン濃縮物およびその製造法 |
| DE10306177A1 (de) * | 2003-02-13 | 2004-09-02 | Aquanova German Solubilisate Technologies (Agt) | Wirkstoffkonzentrate |
| DE20319249U1 (de) * | 2003-12-10 | 2004-12-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Lutein-Konzentrat |
| CN1870906A (zh) * | 2004-07-22 | 2006-11-29 | 德国阿奎诺瓦增溶技术有限公司 | 醚油和其他物质的溶解物 |
| US20060287384A1 (en) * | 2004-08-18 | 2006-12-21 | Dariush Behnam | Lipoic acid concentrate |
| CN101026966A (zh) * | 2004-09-27 | 2007-08-29 | 雀巢技术公司 | 护肤饮料组合物 |
| DE102006024911A1 (de) * | 2006-05-24 | 2007-11-29 | Aquanova Ag | Boswellinsäure-Konzentrat |
| EP1904042A2 (de) * | 2005-07-08 | 2008-04-02 | Aquanova Ag | Wirkstoffextrakt-solubilisate |
| JP2007016000A (ja) * | 2005-07-11 | 2007-01-25 | Taiyo Kagaku Co Ltd | チオクト酸含有組成物 |
| RU2440779C2 (ru) * | 2006-03-07 | 2012-01-27 | Дритте Патентпортфолио Бетайлигунгсгезельшафт Мбх Унд Ко.Кг, | Солюбилизаты консервантов и способ их получения |
| US20100129453A1 (en) * | 2006-09-22 | 2010-05-27 | Daniel Strasser | Emulsions comprising rubber arabicum |
| CA2707010A1 (en) * | 2007-12-14 | 2009-06-25 | Kazuhisa Sugimoto | .alpha.-lipoic acid nanoparticles and methods for preparing thereof |
| EP2488022B1 (en) | 2009-10-16 | 2018-01-10 | Mochida Pharmaceutical Co., Ltd. | Compositions |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| BR112012011336A2 (pt) * | 2009-10-22 | 2018-10-16 | Api Genesis Llc | Composições compreendendo flavonoides, seu método de preparação, adesivo para aplicação de flavonoide, métodos de produção de flavonoide hidratado,métodos de preparação de formulação tópica, e uso de flavonoide |
| CN105168135A (zh) | 2010-03-12 | 2015-12-23 | 博格有限责任公司 | 辅酶Q10(CoQ10)的静脉内制剂及其使用方法 |
| KR101817635B1 (ko) * | 2010-10-22 | 2018-01-11 | 비쭈리 헬스 사이언스 엘엘씨 | 난용성 화합물의 용해도를 증가시키는 방법과 이와 같은 화합물의 제형을 제조하는 방법 및 사용하는 방법 |
| US10973763B2 (en) | 2011-06-17 | 2021-04-13 | Berg Llc | Inhalable pharmaceutical compositions |
| DE102012103767A1 (de) * | 2012-04-27 | 2013-10-31 | Chemische Fabrik Budenheim Kg | Antimikrobielles Mittel |
| DE202012012130U1 (de) * | 2012-12-19 | 2014-03-21 | Aquanova Ag | Curcuminsolubilisat |
| JP7063558B2 (ja) * | 2017-08-03 | 2022-05-09 | 花王株式会社 | 膜構造体の製造方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3052608A (en) * | 1959-05-07 | 1962-09-04 | Joseph J Hirsh | Lanolin transparent emulsions |
| US3390098A (en) * | 1964-06-08 | 1968-06-25 | Armour Pharma | Antioxidant composition |
| US4146499A (en) * | 1976-09-18 | 1979-03-27 | Rosano Henri L | Method for preparing microemulsions |
| DE3048000A1 (de) * | 1980-12-19 | 1982-07-15 | Basf Ag | Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung |
| JP2565513B2 (ja) * | 1987-09-25 | 1996-12-18 | 三省製薬株式会社 | メラニン生成抑制外用薬剤 |
| JPH03165833A (ja) * | 1989-02-28 | 1991-07-17 | Isamu Horikoshi | 新規懸濁化方法及びこの方法によって得られる組成物 |
| CA2010894A1 (en) * | 1989-02-28 | 1990-08-31 | Isamu Horikoshi | Method of forming a suspension and composition formed by said method |
| DE59010810D1 (de) * | 1989-11-09 | 1998-04-16 | Asta Medica Ag | Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure |
| DE4038385C2 (de) * | 1990-12-01 | 1998-09-17 | Hoyer Gmbh & Co Kg | Sitosterol und seine Glykoside mit verbesserter Bioverfügbarkeit |
| US5569670A (en) * | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
| CH685325A5 (de) * | 1994-01-04 | 1995-06-15 | Marigen Sa | Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit schwer löslichen Carotinen. |
| DE69515028T2 (de) * | 1994-03-22 | 2000-06-29 | The Immune Response Corp., Carlsbad | Die hocheffiziente herstellung und isolierung von viruspartikeln |
| WO1997010814A1 (en) * | 1995-09-18 | 1997-03-27 | Vesifact Ag | Propofol nanodispersions |
| DE69727244T2 (de) * | 1996-10-03 | 2004-11-25 | Hermes Biosciences Inc., San Francisco | Hydrophile Mikroteilchen und Verfahren zu deren Herstellung |
| DE19647352C2 (de) * | 1996-11-15 | 2000-06-29 | Aqua Nova Getraenketechnologie | Nicht alkoholisches Getränk mit einem Gehalt an Q 10 |
| WO1999029316A1 (en) * | 1997-12-10 | 1999-06-17 | Severson, Mary, L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
| US6251420B1 (en) * | 1998-01-28 | 2001-06-26 | Dusan Miljkovic | Isoflavanoid formulations for oral administration |
| JP3335307B2 (ja) * | 1998-03-19 | 2002-10-15 | 株式会社東芝 | ソルダーペースト及びハンダ接合形成用フラックス |
| AU3843999A (en) * | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| EP0956779A1 (de) * | 1998-05-11 | 1999-11-17 | Vesifact Ag | Nahrungsmittel, welche wasserunlösliche Komponenten enthalten |
| US6197340B1 (en) * | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| AU7638300A (en) * | 1999-10-20 | 2001-04-30 | Vesifact Ag | Microemulsion preconcentrates and microemulsions |
| US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
| DE10104847B4 (de) * | 2000-06-09 | 2006-12-21 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Tocopherol-Konzentrat und Verfahren zu seiner Herstellung |
| DE10103454A1 (de) * | 2000-12-29 | 2002-08-01 | Aquanova Getraenketechnologie | Wirkstoffkonzentrate sowie Verfahren zu ihrer Herstellung |
| DE50213362D1 (de) * | 2001-02-11 | 2009-04-30 | Aquanova Ag | Verfahren zur herstellung eines isoflavon-konzentrats |
-
2002
- 2002-02-11 DE DE50213362T patent/DE50213362D1/de not_active Expired - Lifetime
- 2002-02-11 WO PCT/EP2002/001416 patent/WO2002085328A2/de not_active Ceased
- 2002-02-11 AU AU2002250914A patent/AU2002250914A1/en not_active Abandoned
- 2002-02-11 CA CA002436273A patent/CA2436273A1/en not_active Abandoned
- 2002-02-11 US US10/470,749 patent/US20040081670A1/en not_active Abandoned
- 2002-02-11 MX MXPA03007141A patent/MXPA03007141A/es active IP Right Grant
- 2002-02-11 EP EP02719799A patent/EP1377273B1/de not_active Expired - Lifetime
- 2002-02-11 EP EP05027278A patent/EP1645267A3/de not_active Withdrawn
- 2002-02-11 JP JP2002582902A patent/JP2004531530A/ja active Pending
- 2002-02-11 EP EP04010510A patent/EP1475083B1/de not_active Expired - Lifetime
- 2002-02-11 ES ES02719799T patent/ES2324400T3/es not_active Expired - Lifetime
- 2002-02-11 DE DE50211435T patent/DE50211435D1/de not_active Expired - Lifetime
- 2002-02-11 AT AT02719799T patent/ATE425743T1/de active
- 2002-02-11 AT AT04010510T patent/ATE381923T1/de active
-
2006
- 2006-04-19 JP JP2006115962A patent/JP2006241167A/ja active Pending
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