JP2004531530A - 活性物質の濃縮物の製法および活性物質の濃縮物 - Google Patents

活性物質の濃縮物の製法および活性物質の濃縮物 Download PDF

Info

Publication number
JP2004531530A
JP2004531530A JP2002582902A JP2002582902A JP2004531530A JP 2004531530 A JP2004531530 A JP 2004531530A JP 2002582902 A JP2002582902 A JP 2002582902A JP 2002582902 A JP2002582902 A JP 2002582902A JP 2004531530 A JP2004531530 A JP 2004531530A
Authority
JP
Japan
Prior art keywords
active substance
water
micelles
polysorbate
concentrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002582902A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004531530A5 (https=
Inventor
ダリウシュ・ベーナム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aquanova AG
Original Assignee
Aquanova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10109708A external-priority patent/DE10109708A1/de
Priority claimed from DE10108614A external-priority patent/DE10108614B4/de
Application filed by Aquanova AG filed Critical Aquanova AG
Publication of JP2004531530A publication Critical patent/JP2004531530A/ja
Publication of JP2004531530A5 publication Critical patent/JP2004531530A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11Plant sterols or derivatives thereof, e.g. phytosterols
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
JP2002582902A 2001-02-11 2002-02-11 活性物質の濃縮物の製法および活性物質の濃縮物 Pending JP2004531530A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10109708A DE10109708A1 (de) 2001-02-11 2001-02-11 Wasserlösliches Wirkstoffkonzentrat
DE10108614A DE10108614B4 (de) 2001-02-22 2001-02-22 Wasserlösliches Konzentrat eines stoffwechselbeeinflussenden Wirkstoffes
PCT/EP2002/001416 WO2002085328A2 (de) 2001-02-11 2002-02-11 Verfahren zur herstellung eines wirkstoffkonzentrats sowie wirkstoffkonzentrat

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006115962A Division JP2006241167A (ja) 2001-02-11 2006-04-19 活性物質の濃縮物の製法および活性物質の濃縮物

Publications (2)

Publication Number Publication Date
JP2004531530A true JP2004531530A (ja) 2004-10-14
JP2004531530A5 JP2004531530A5 (https=) 2006-06-15

Family

ID=26008603

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002582902A Pending JP2004531530A (ja) 2001-02-11 2002-02-11 活性物質の濃縮物の製法および活性物質の濃縮物
JP2006115962A Pending JP2006241167A (ja) 2001-02-11 2006-04-19 活性物質の濃縮物の製法および活性物質の濃縮物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006115962A Pending JP2006241167A (ja) 2001-02-11 2006-04-19 活性物質の濃縮物の製法および活性物質の濃縮物

Country Status (10)

Country Link
US (1) US20040081670A1 (https=)
EP (3) EP1377273B1 (https=)
JP (2) JP2004531530A (https=)
AT (2) ATE425743T1 (https=)
AU (1) AU2002250914A1 (https=)
CA (1) CA2436273A1 (https=)
DE (2) DE50213362D1 (https=)
ES (1) ES2324400T3 (https=)
MX (1) MXPA03007141A (https=)
WO (1) WO2002085328A2 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006241167A (ja) * 2001-02-11 2006-09-14 Aquanova German Solubilisate Technologies (Agt) Gmbh 活性物質の濃縮物の製法および活性物質の濃縮物
JP2007016000A (ja) * 2005-07-11 2007-01-25 Taiyo Kagaku Co Ltd チオクト酸含有組成物
JP2013508361A (ja) * 2009-10-22 2013-03-07 エイピーアイ・ジェネシス,エルエルシー フラボノイド含有組成物の製造方法及び使用
JP2013508296A (ja) * 2009-10-16 2013-03-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 組成物
KR20150095698A (ko) * 2012-12-19 2015-08-21 아쿠아노바 아게 커큐민 가용화물
US9730953B2 (en) 2009-10-22 2017-08-15 Vizuri Health Sciences Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound
JP2019026623A (ja) * 2017-08-03 2019-02-21 花王株式会社 膜構造体の製造方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531616A (ja) 2002-06-29 2005-10-20 アクヴァノヴァ・ジャーマン・ソリュービリセイト・テクノロジーズ・(アーゲーテー)・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング イソフラボン濃縮物およびその製造法
DE10306177A1 (de) * 2003-02-13 2004-09-02 Aquanova German Solubilisate Technologies (Agt) Wirkstoffkonzentrate
DE20319249U1 (de) * 2003-12-10 2004-12-30 Aquanova German Solubilisate Technologies (Agt) Gmbh Lutein-Konzentrat
CN1870906A (zh) * 2004-07-22 2006-11-29 德国阿奎诺瓦增溶技术有限公司 醚油和其他物质的溶解物
US20060287384A1 (en) * 2004-08-18 2006-12-21 Dariush Behnam Lipoic acid concentrate
CN101026966A (zh) * 2004-09-27 2007-08-29 雀巢技术公司 护肤饮料组合物
DE102006024911A1 (de) * 2006-05-24 2007-11-29 Aquanova Ag Boswellinsäure-Konzentrat
EP1904042A2 (de) * 2005-07-08 2008-04-02 Aquanova Ag Wirkstoffextrakt-solubilisate
RU2440779C2 (ru) * 2006-03-07 2012-01-27 Дритте Патентпортфолио Бетайлигунгсгезельшафт Мбх Унд Ко.Кг, Солюбилизаты консервантов и способ их получения
US20100129453A1 (en) * 2006-09-22 2010-05-27 Daniel Strasser Emulsions comprising rubber arabicum
CA2707010A1 (en) * 2007-12-14 2009-06-25 Kazuhisa Sugimoto .alpha.-lipoic acid nanoparticles and methods for preparing thereof
CN105168135A (zh) 2010-03-12 2015-12-23 博格有限责任公司 辅酶Q10(CoQ10)的静脉内制剂及其使用方法
KR101817635B1 (ko) * 2010-10-22 2018-01-11 비쭈리 헬스 사이언스 엘엘씨 난용성 화합물의 용해도를 증가시키는 방법과 이와 같은 화합물의 제형을 제조하는 방법 및 사용하는 방법
US10973763B2 (en) 2011-06-17 2021-04-13 Berg Llc Inhalable pharmaceutical compositions
DE102012103767A1 (de) * 2012-04-27 2013-10-31 Chemische Fabrik Budenheim Kg Antimikrobielles Mittel

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052608A (en) * 1959-05-07 1962-09-04 Joseph J Hirsh Lanolin transparent emulsions
US3390098A (en) * 1964-06-08 1968-06-25 Armour Pharma Antioxidant composition
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
JP2565513B2 (ja) * 1987-09-25 1996-12-18 三省製薬株式会社 メラニン生成抑制外用薬剤
JPH03165833A (ja) * 1989-02-28 1991-07-17 Isamu Horikoshi 新規懸濁化方法及びこの方法によって得られる組成物
CA2010894A1 (en) * 1989-02-28 1990-08-31 Isamu Horikoshi Method of forming a suspension and composition formed by said method
DE59010810D1 (de) * 1989-11-09 1998-04-16 Asta Medica Ag Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure
DE4038385C2 (de) * 1990-12-01 1998-09-17 Hoyer Gmbh & Co Kg Sitosterol und seine Glykoside mit verbesserter Bioverfügbarkeit
US5569670A (en) * 1992-06-05 1996-10-29 Asta Medica Aktiengesellschaft Combination medications containing alpha-lipoic acid and related
CH685325A5 (de) * 1994-01-04 1995-06-15 Marigen Sa Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit schwer löslichen Carotinen.
DE69515028T2 (de) * 1994-03-22 2000-06-29 The Immune Response Corp., Carlsbad Die hocheffiziente herstellung und isolierung von viruspartikeln
WO1997010814A1 (en) * 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
DE69727244T2 (de) * 1996-10-03 2004-11-25 Hermes Biosciences Inc., San Francisco Hydrophile Mikroteilchen und Verfahren zu deren Herstellung
DE19647352C2 (de) * 1996-11-15 2000-06-29 Aqua Nova Getraenketechnologie Nicht alkoholisches Getränk mit einem Gehalt an Q 10
WO1999029316A1 (en) * 1997-12-10 1999-06-17 Severson, Mary, L. Pharmaceutical compositions containing an omega-3 fatty acid oil
US6251420B1 (en) * 1998-01-28 2001-06-26 Dusan Miljkovic Isoflavanoid formulations for oral administration
JP3335307B2 (ja) * 1998-03-19 2002-10-15 株式会社東芝 ソルダーペースト及びハンダ接合形成用フラックス
AU3843999A (en) * 1998-05-07 1999-11-23 Elan Corporation, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
EP0956779A1 (de) * 1998-05-11 1999-11-17 Vesifact Ag Nahrungsmittel, welche wasserunlösliche Komponenten enthalten
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
AU7638300A (en) * 1999-10-20 2001-04-30 Vesifact Ag Microemulsion preconcentrates and microemulsions
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
DE10104847B4 (de) * 2000-06-09 2006-12-21 Aquanova German Solubilisate Technologies (Agt) Gmbh Tocopherol-Konzentrat und Verfahren zu seiner Herstellung
DE10103454A1 (de) * 2000-12-29 2002-08-01 Aquanova Getraenketechnologie Wirkstoffkonzentrate sowie Verfahren zu ihrer Herstellung
DE50213362D1 (de) * 2001-02-11 2009-04-30 Aquanova Ag Verfahren zur herstellung eines isoflavon-konzentrats

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006241167A (ja) * 2001-02-11 2006-09-14 Aquanova German Solubilisate Technologies (Agt) Gmbh 活性物質の濃縮物の製法および活性物質の濃縮物
JP2007016000A (ja) * 2005-07-11 2007-01-25 Taiyo Kagaku Co Ltd チオクト酸含有組成物
JP2018048163A (ja) * 2009-10-16 2018-03-29 持田製薬株式会社 組成物
JP2013508296A (ja) * 2009-10-16 2013-03-07 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 組成物
US9730953B2 (en) 2009-10-22 2017-08-15 Vizuri Health Sciences Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound
JP2013508361A (ja) * 2009-10-22 2013-03-07 エイピーアイ・ジェネシス,エルエルシー フラボノイド含有組成物の製造方法及び使用
US11135177B2 (en) 2009-10-22 2021-10-05 Vizuri Health Sciences Consumer Healthcare, Inc. Methods of making and using compositions comprising flavonoids
US11491226B2 (en) 2009-10-22 2022-11-08 Technology Investments Lc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound
JP2016505579A (ja) * 2012-12-19 2016-02-25 アクアノヴァ アクチエンゲゼルシャフト クルクミン可溶化物
KR20150095698A (ko) * 2012-12-19 2015-08-21 아쿠아노바 아게 커큐민 가용화물
KR101983332B1 (ko) * 2012-12-19 2019-09-03 아쿠아노바 아게 커큐민 가용화물
US11311483B2 (en) 2012-12-19 2022-04-26 Aquanova Ag Curcumin solubilisate
JP2019026623A (ja) * 2017-08-03 2019-02-21 花王株式会社 膜構造体の製造方法
JP7063558B2 (ja) 2017-08-03 2022-05-09 花王株式会社 膜構造体の製造方法

Also Published As

Publication number Publication date
EP1377273A2 (de) 2004-01-07
EP1377273B1 (de) 2009-03-18
ATE381923T1 (de) 2008-01-15
DE50213362D1 (de) 2009-04-30
WO2002085328A2 (de) 2002-10-31
MXPA03007141A (es) 2003-11-18
EP1645267A2 (de) 2006-04-12
EP1475083B1 (de) 2007-12-26
DE50211435D1 (de) 2008-02-07
WO2002085328A3 (de) 2003-11-06
JP2006241167A (ja) 2006-09-14
ES2324400T3 (es) 2009-08-06
US20040081670A1 (en) 2004-04-29
HK1073994A1 (zh) 2005-10-28
CA2436273A1 (en) 2002-10-31
AU2002250914A1 (en) 2002-11-05
ATE425743T1 (de) 2009-04-15
EP1475083A1 (de) 2004-11-10
EP1645267A3 (de) 2007-10-10

Similar Documents

Publication Publication Date Title
JP2004531530A (ja) 活性物質の濃縮物の製法および活性物質の濃縮物
Tang et al. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) as food-grade nanovehicles for hydrophobic nutraceuticals or bioactives
JP7581151B2 (ja) マルチサプリメント組成物
Huang et al. Nanostructured lipid carrier (NLC) as a strategy for encapsulation of quercetin and linseed oil: Preparation and in vitro characterization studies
Mouhid et al. Improving in vivo efficacy of bioactive molecules: An overview of potentially antitumor phytochemicals and currently available lipid‐based delivery systems
JP4117184B2 (ja) アスコルビン酸水溶液
CN102131407A (zh) 含有非极性化合物的组合物
JP2005500369A (ja) 改良された生物学的利用能を有する製剤における高分子量で親油性で経口摂取可能な生物活性物質
JP2002508336A (ja) 構造化グリセリドを用いた脂溶性化合物の吸収および輸送の促進方法
CN103190631A (zh) 非水性预乳液组合物及制备包含植物甾醇的饮料的方法
CN112399847B (zh) 维生素k2微胶囊及其制备方法和在制备防治心脑血管疾病的药物中的应用
JP2015514683A (ja) 食品性栄養組成物および使用方法
Kumar et al. Scope of nanotechnology in nutraceuticals
Ezzat et al. Lecithin
WO2015040616A1 (en) Potato protein nanoparticles
TWI339125B (en) Aqueous solution of ascorbic acid and method for producing same
Chandan et al. Formulation and stability enhancement using vitamin A encapsulation in ocular abnormalities: A scientific review
JP5735576B2 (ja) コエンザイムq10を含有する組成物
Cvetković et al. Can Carotenoids Cure Or Protect Us? A
JP5683768B2 (ja) コエンザイムq10を含有する組成物
KR102573152B1 (ko) 커큐민 및 선택적으로 적어도 1종의 다른 활성 물질을 갖는 가용화물
HK1073994B (en) Method for producing an active ingredient concentrate, and active ingredient concentrate
JP2024060517A (ja) 油性組成物及びそれを含むカプセル製剤
HK1059733A (en) Aqeous solution of ascorbic acid

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040824

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060419

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080422

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080924