JP2004529118A5 - - Google Patents
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- Publication number
- JP2004529118A5 JP2004529118A5 JP2002571109A JP2002571109A JP2004529118A5 JP 2004529118 A5 JP2004529118 A5 JP 2004529118A5 JP 2002571109 A JP2002571109 A JP 2002571109A JP 2002571109 A JP2002571109 A JP 2002571109A JP 2004529118 A5 JP2004529118 A5 JP 2004529118A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- conjugate
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01105350A EP1238678A1 (en) | 2001-03-08 | 2001-03-08 | Enzyme-activated cytostatic conjugates with integrin ligands |
| PCT/EP2002/002501 WO2002072151A1 (en) | 2001-03-08 | 2002-03-07 | Enzyme-activated cytostatic conjugates with integrin ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529118A JP2004529118A (ja) | 2004-09-24 |
| JP2004529118A5 true JP2004529118A5 (https=) | 2005-12-22 |
Family
ID=8176682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571109A Pending JP2004529118A (ja) | 2001-03-08 | 2002-03-07 | インテグリンリガンドを有する酵素活性化細胞分裂停止接合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7304037B2 (https=) |
| EP (2) | EP1238678A1 (https=) |
| JP (1) | JP2004529118A (https=) |
| CA (1) | CA2439897A1 (https=) |
| WO (1) | WO2002072151A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102453036B (zh) * | 2010-10-27 | 2015-12-02 | 李红玉 | 一种喜树碱类化合物及其制备方法和在农药中的用途 |
| US9737556B2 (en) | 2014-06-13 | 2017-08-22 | Trustees Of Tufts College | FAP-activated therapeutic agents, and uses related thereto |
| CN106573073B (zh) | 2014-06-13 | 2021-09-28 | 塔夫茨大学信托人 | Fap激活的治疗剂以及其相关用途 |
| EA202191244A1 (ru) * | 2018-11-05 | 2021-10-11 | Байер Фарма Акциенгезельшафт | Новые цитостатические конъюгаты с лигандами интегрина |
| CN109575051B (zh) * | 2019-01-23 | 2021-07-27 | 遵义医科大学 | 一种天然药物成分修饰衍生物及其抗肿瘤应用 |
| US20230293716A1 (en) | 2020-05-08 | 2023-09-21 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
| WO2023057813A1 (en) | 2021-10-04 | 2023-04-13 | Vincerx Pharma Gmbh | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders |
| WO2023057814A1 (en) | 2021-10-04 | 2023-04-13 | Vincerx Pharma Gmbh | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders |
| WO2023057812A1 (en) | 2021-10-04 | 2023-04-13 | Vincerx Pharma Gmbh | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder |
| JP2025537882A (ja) | 2022-11-17 | 2025-11-20 | ハンス－ゲオルク レルケン | 腫瘍微小環境において切断可能な小分子－薬物コンジュゲート |
| GB202407865D0 (en) | 2024-06-03 | 2024-07-17 | Elasmogen Ltd | Self immolative compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3611194A1 (de) | 1986-04-04 | 1987-10-08 | Bayer Ag | Cancerostatisches mittel |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US4980343A (en) | 1988-10-27 | 1990-12-25 | Bayer Aktiengesellschaft | Aminooxodihydroisoindoloquinazoline carcinostatic agents |
| CA2076982A1 (en) | 1990-12-27 | 1992-06-28 | Akira Okura | Pyridonecarboxylic acid derivatives |
| US5561116A (en) * | 1991-04-11 | 1996-10-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Solid product containing propolis components, and preparation and uses thereof |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| DE4120646A1 (de) | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| DE4229903A1 (de) | 1992-09-08 | 1994-03-10 | Bayer Ag | Neue Acetale von Ketophosphamid und Alkylglycosiden |
| DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| DE19512484A1 (de) | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
| CA2265484C (en) * | 1996-09-10 | 2008-12-02 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
| ID23424A (id) | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
| JP2002510709A (ja) * | 1998-04-08 | 2002-04-09 | ジー・ディー・サール・アンド・カンパニー | 二重Ａｖｂ３及び転移関連受容体リガンド |
| US6291503B1 (en) | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
| CA2370245A1 (en) * | 1999-05-14 | 2000-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Enzyme-activated anti-tumor prodrug compounds |
| ATE438413T1 (de) * | 1999-09-08 | 2009-08-15 | Markus Albers | Integrin-vermittelte arzneimittel-zielrichtung |
-
2001
- 2001-03-08 EP EP01105350A patent/EP1238678A1/en not_active Withdrawn
-
2002
- 2002-03-07 EP EP20020702402 patent/EP1372732A1/en not_active Withdrawn
- 2002-03-07 WO PCT/EP2002/002501 patent/WO2002072151A1/en not_active Ceased
- 2002-03-07 JP JP2002571109A patent/JP2004529118A/ja active Pending
- 2002-03-07 CA CA002439897A patent/CA2439897A1/en not_active Abandoned
- 2002-03-08 US US10/096,120 patent/US7304037B2/en not_active Expired - Fee Related
-
2007
- 2007-12-04 US US11/999,445 patent/US20080108576A1/en not_active Abandoned
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