JP2004529088A - ＩｋＢキナーゼ（ＩＫＫ）のインヒビターを用いる炎症性および免疫疾患の処置法 - Google Patents

ＩｋＢキナーゼ（ＩＫＫ）のインヒビターを用いる炎症性および免疫疾患の処置法 Download PDF

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JP2004529088A
JP2004529088A JP2002560582A JP2002560582A JP2004529088A JP 2004529088 A JP2004529088 A JP 2004529088A JP 2002560582 A JP2002560582 A JP 2002560582A JP 2002560582 A JP2002560582 A JP 2002560582A JP 2004529088 A JP2004529088 A JP 2004529088A
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ikk
inhibitor
activity
disease
inflammatory
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Japanese (ja)
Inventor
ジェイムズ・アール・バーク
スティーブン・ナドラー
キウ・ユピン
ロバート・エム・タウンセンド
フレッド・クリストファー・ズシ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Priority claimed from US09/965,977 external-priority patent/US6960585B2/en
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Physical Education & Sports Medicine (AREA)
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  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
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  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002560582A 2001-02-01 2002-02-01 ＩｋＢキナーゼ（ＩＫＫ）のインヒビターを用いる炎症性および免疫疾患の処置法 Pending JP2004529088A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26585301P 2001-02-01 2001-02-01
US09/965,977 US6960585B2 (en) 2000-10-03 2001-09-27 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
PCT/US2002/003060 WO2002060386A2 (en) 2001-02-01 2002-02-01 METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF IλB KINASE (IKK)

Publications (1)

Publication Number Publication Date
JP2004529088A true JP2004529088A (ja) 2004-09-24

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JP2002560582A Pending JP2004529088A (ja) 2001-02-01 2002-02-01 ＩｋＢキナーゼ（ＩＫＫ）のインヒビターを用いる炎症性および免疫疾患の処置法

Country Status (10)

Country Link
EP (1) EP1363993A4 (cs)
JP (1) JP2004529088A (cs)
AU (1) AU2002247059B2 (cs)
CA (1) CA2436770A1 (cs)
CZ (1) CZ20032287A3 (cs)
HU (1) HUP0304045A3 (cs)
MX (1) MXPA03006817A (cs)
NO (1) NO20033429L (cs)
PL (1) PL364111A1 (cs)
WO (1) WO2002060386A2 (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004512281A (ja) * 2000-10-03 2004-04-22 ブリストル−マイヤーズ　スクイブ　カンパニー 抗炎症薬として有用なアミノ置換４環化合物および該化合物を含有する医薬組成物
WO2008072779A1 (ja) * 2006-12-13 2008-06-19 Aska Pharmaceutical Co., Ltd. キノキサリン誘導体
JP2021505611A (ja) * 2017-12-07 2021-02-18 ユニベルジテート ツー ケルンＵｎｉｖｅｒｓｉｔａｅｔ ｚｕ Ｋｏｅｌｎ 免疫疾患の予防または治療のためのｒｉｐｋ１阻害剤とｉｋｋ阻害剤の組み合わせ

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846834B2 (en) 2000-10-26 2005-01-25 Amgen Inc. Antiinflammation agents
WO2003048152A2 (en) 2001-12-05 2003-06-12 Tularik Inc. Inflammation modulators
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
CA2502429A1 (en) 2002-10-31 2004-05-21 Amgen Inc. Antiinflammation agents
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
BRPI0611674A2 (pt) 2005-06-30 2009-04-28 Smithkline Beecham Corp compostos quÍmicos
US20100069387A1 (en) * 2005-09-07 2010-03-18 Palmer Stephen S IKK Inhibitors for the Treatment of Endometriosis
US20090175852A1 (en) 2006-06-06 2009-07-09 Schering Corporation Imidazopyrazines as protein kinase inhibitors
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
BRPI0910850B1 (pt) 2008-04-21 2022-06-14 Otonomy, Inc. Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva
WO2010000903A2 (es) * 2008-06-30 2010-01-07 Centro De Investigaciones Energéticas, Medioambientales Y Tecnológicas (Ciemat) Composición capaz de modular la actividad de ikkalpha para el tratamiento de enfermedades que cursan con acantolisis
KR101323448B1 (ko) 2008-10-02 2013-11-27 아사히 가세이 파마 가부시키가이샤 ８위 치환 이소퀴놀린 유도체 및 이의 용도
JP2012520257A (ja) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160097A (en) * 1977-01-07 1979-07-03 Westwind Pharmaceuticals, Inc. 1-(2-Phenylureylene)imidazoles
US5851812A (en) * 1997-07-01 1998-12-22 Tularik Inc. IKK-β proteins, nucleic acids and methods
US6235740B1 (en) * 1997-08-25 2001-05-22 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
US6030834A (en) * 1997-12-30 2000-02-29 Chiron Corporation Human IKK-beta DNA constructs and cells
GB0003154D0 (en) * 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
HRP20020748A2 (en) * 2000-03-15 2005-02-28 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines with ikb-kinase inhibiting activity
DE60117835T2 (de) * 2000-10-03 2006-10-19 Bristol-Myers Squibb Co. Amino- substituierte tetracyclische Verbindungen,die als entzündungshemmende Mittel nützlich sind, und diese enthaltende Arzneimittel

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004512281A (ja) * 2000-10-03 2004-04-22 ブリストル−マイヤーズ　スクイブ　カンパニー 抗炎症薬として有用なアミノ置換４環化合物および該化合物を含有する医薬組成物
WO2008072779A1 (ja) * 2006-12-13 2008-06-19 Aska Pharmaceutical Co., Ltd. キノキサリン誘導体
JP5578786B2 (ja) * 2006-12-13 2014-08-27 あすか製薬株式会社 キノキサリン誘導体
JP2021505611A (ja) * 2017-12-07 2021-02-18 ユニベルジテート ツー ケルンＵｎｉｖｅｒｓｉｔａｅｔ ｚｕ Ｋｏｅｌｎ 免疫疾患の予防または治療のためのｒｉｐｋ１阻害剤とｉｋｋ阻害剤の組み合わせ
JP7527639B2 (ja) 2017-12-07 2024-08-05 ユニベルジテート ツー ケルン 免疫疾患の予防または治療のためのｒｉｐｋ１阻害剤とｉｋｋ阻害剤の組み合わせ

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HUP0304045A2 (hu) 2004-04-28
MXPA03006817A (es) 2003-11-13
CZ20032287A3 (cs) 2004-02-18
WO2002060386A2 (en) 2002-08-08
EP1363993A2 (en) 2003-11-26
EP1363993A4 (en) 2008-11-12
HUP0304045A3 (en) 2005-05-30
WO2002060386A3 (en) 2002-10-10
NO20033429L (no) 2003-09-24
CA2436770A1 (en) 2002-08-08
NO20033429D0 (no) 2003-07-31
PL364111A1 (en) 2004-12-13
AU2002247059B2 (en) 2006-11-16

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