JP2004527530A5 - - Google Patents
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- Publication number
- JP2004527530A5 JP2004527530A5 JP2002579414A JP2002579414A JP2004527530A5 JP 2004527530 A5 JP2004527530 A5 JP 2004527530A5 JP 2002579414 A JP2002579414 A JP 2002579414A JP 2002579414 A JP2002579414 A JP 2002579414A JP 2004527530 A5 JP2004527530 A5 JP 2004527530A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyacetamide
- group
- hydroxy
- acetamide
- diiodophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 125000003158 alcohol group Chemical group 0.000 claims 3
- 150000001408 amides Chemical group 0.000 claims 3
- 150000001412 amines Chemical group 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- BDBFKEFBGHYVRI-UHFFFAOYSA-N 2-(3,5-diiodo-4-methoxyphenyl)-n-hydroxyacetamide Chemical compound COC1=C(I)C=C(CC(=O)NO)C=C1I BDBFKEFBGHYVRI-UHFFFAOYSA-N 0.000 claims 2
- WQMVCLNJMNIZON-UHFFFAOYSA-N 2-(3,5-diiodo-4-phenoxyphenyl)-n-hydroxyacetamide Chemical compound IC1=CC(CC(=O)NO)=CC(I)=C1OC1=CC=CC=C1 WQMVCLNJMNIZON-UHFFFAOYSA-N 0.000 claims 2
- SGUQHLKFZZCQGA-UHFFFAOYSA-N 2-(3,5-diiodo-4-phenylmethoxyphenyl)-n-hydroxyacetamide Chemical compound IC1=CC(CC(=O)NO)=CC(I)=C1OCC1=CC=CC=C1 SGUQHLKFZZCQGA-UHFFFAOYSA-N 0.000 claims 2
- KYJMRQVYZISFBB-UHFFFAOYSA-N 2-(3,5-ditert-butyl-4-hydroxyphenyl)-n-hydroxyacetamide Chemical compound CC(C)(C)C1=CC(CC(=O)NO)=CC(C(C)(C)C)=C1O KYJMRQVYZISFBB-UHFFFAOYSA-N 0.000 claims 2
- XBRDWTYULANWRV-UHFFFAOYSA-N 2-(3,5-ditert-butyl-4-methoxyphenyl)-n-hydroxyacetamide Chemical compound COC1=C(C(C)(C)C)C=C(CC(=O)NO)C=C1C(C)(C)C XBRDWTYULANWRV-UHFFFAOYSA-N 0.000 claims 2
- CDAGXQJXQNAKBU-UHFFFAOYSA-N 2-[3-chloro-4-(cyclopropylmethoxy)phenyl]-n-hydroxyacetamide Chemical compound ClC1=CC(CC(=O)NO)=CC=C1OCC1CC1 CDAGXQJXQNAKBU-UHFFFAOYSA-N 0.000 claims 2
- CLAPXZCWNKDKFD-UHFFFAOYSA-N 2-[4-(ethylamino)-3,5-diiodophenyl]-n-hydroxyacetamide Chemical compound CCNC1=C(I)C=C(CC(=O)NO)C=C1I CLAPXZCWNKDKFD-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 150000001735 carboxylic acids Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- INFZLXMDXXPQGA-UHFFFAOYSA-N n-hydroxy-2-(3,4,5-trimethoxyphenyl)acetamide Chemical compound COC1=CC(CC(=O)NO)=CC(OC)=C1OC INFZLXMDXXPQGA-UHFFFAOYSA-N 0.000 claims 2
- UEJPVKVKTCZGFP-UHFFFAOYSA-N n-hydroxy-2-(3-iodo-4-methoxyphenyl)acetamide Chemical compound COC1=CC=C(CC(=O)NO)C=C1I UEJPVKVKTCZGFP-UHFFFAOYSA-N 0.000 claims 2
- MEBKBOJNQHJGCA-UHFFFAOYSA-N n-hydroxy-2-(4-hydroxy-3,5-diiodophenyl)acetamide Chemical compound ONC(=O)CC1=CC(I)=C(O)C(I)=C1 MEBKBOJNQHJGCA-UHFFFAOYSA-N 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- KKTHMPAJCDVKBJ-UHFFFAOYSA-N 2-(3,5-dichloro-4-methoxyphenyl)-n-hydroxyacetamide Chemical compound COC1=C(Cl)C=C(CC(=O)NO)C=C1Cl KKTHMPAJCDVKBJ-UHFFFAOYSA-N 0.000 claims 1
- SMNAANDQAOLROJ-UHFFFAOYSA-N 2-(3,5-dichloro-4-phenoxyphenyl)-n-hydroxyacetamide Chemical compound ClC1=CC(CC(=O)NO)=CC(Cl)=C1OC1=CC=CC=C1 SMNAANDQAOLROJ-UHFFFAOYSA-N 0.000 claims 1
- MWVYYUXWRATDHP-UHFFFAOYSA-N 2-(4-amino-3,5-diiodophenyl)-n-hydroxyacetamide Chemical compound NC1=C(I)C=C(CC(=O)NO)C=C1I MWVYYUXWRATDHP-UHFFFAOYSA-N 0.000 claims 1
- VQOWOIXHPJYOAJ-UHFFFAOYSA-N 2-[4-[4-[2-(diethylamino)ethoxy]phenoxy]-3,5-diiodophenyl]-n-hydroxyacetamide Chemical compound C1=CC(OCCN(CC)CC)=CC=C1OC1=C(I)C=C(CC(=O)NO)C=C1I VQOWOIXHPJYOAJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- USLUOOGWHDRFFN-UHFFFAOYSA-N n-hydroxy-2-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetamide Chemical compound IC1=CC(CC(=O)NO)=CC(I)=C1OC1=CC=C(O)C=C1 USLUOOGWHDRFFN-UHFFFAOYSA-N 0.000 claims 1
- HSIALXIYDPTUSI-UHFFFAOYSA-N n-hydroxy-2-[4-(4-hydroxyphenoxy)-3-iodophenyl]acetamide Chemical compound IC1=CC(CC(=O)NO)=CC=C1OC1=CC=C(O)C=C1 HSIALXIYDPTUSI-UHFFFAOYSA-N 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 claims 1
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28161301P | 2001-04-05 | 2001-04-05 | |
| PCT/US2002/010506 WO2002081426A1 (en) | 2001-04-05 | 2002-04-04 | Peptide deformylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527530A JP2004527530A (ja) | 2004-09-09 |
| JP2004527530A5 true JP2004527530A5 (https=) | 2005-12-22 |
Family
ID=23078046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579414A Pending JP2004527530A (ja) | 2001-04-05 | 2002-04-04 | ペプチドデホルミラーゼ阻害物質 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20040267015A1 (https=) |
| EP (1) | EP1383729A4 (https=) |
| JP (1) | JP2004527530A (https=) |
| WO (1) | WO2002081426A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140107166A1 (en) * | 2011-02-14 | 2014-04-17 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors and methods of use thereof |
| CN109020825B (zh) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | 抗流感病毒化合物及其制备方法 |
| WO2019168842A1 (en) | 2018-03-02 | 2019-09-06 | Oregon Health & Science University | Amide prodrugs of small molecule nuclear receptor modulators |
| EP3894383A1 (en) | 2018-12-12 | 2021-10-20 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| CA3130371A1 (en) | 2019-03-01 | 2020-09-10 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| KR20220121239A (ko) | 2019-11-29 | 2022-08-31 | 아우토반 쎄라퓨틱스, 인크. | 신규한 갑상선 호르몬 모방제 |
| JP7813730B2 (ja) | 2020-06-17 | 2026-02-13 | オートバーン セラピューティクス，インク． | 甲状腺様作用剤 |
| WO2021257851A1 (en) | 2020-06-17 | 2021-12-23 | Autobahn Therapeutics, Inc. | Thyromimetics |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE689347A (https=) * | 1965-12-09 | 1967-04-14 | Madan Ag | |
| US4052514A (en) * | 1971-03-26 | 1977-10-04 | The Boots Company Limited | Trihalosubstituted biphenylyl propionic acids |
| US4792560A (en) * | 1985-04-03 | 1988-12-20 | Rorer Pharmaceutical Corporation | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
| NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
| WO2001038561A1 (en) * | 1999-11-29 | 2001-05-31 | Questcor Pharmaceuticals, Inc. | Methods of use of peptide deformylase inhibitors as novel antibacterial agents |
-
2002
- 2002-04-04 US US10/473,104 patent/US20040267015A1/en not_active Abandoned
- 2002-04-04 WO PCT/US2002/010506 patent/WO2002081426A1/en not_active Ceased
- 2002-04-04 EP EP02721667A patent/EP1383729A4/en not_active Withdrawn
- 2002-04-04 JP JP2002579414A patent/JP2004527530A/ja active Pending
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