JP2004526459A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004526459A5 JP2004526459A5 JP2002589661A JP2002589661A JP2004526459A5 JP 2004526459 A5 JP2004526459 A5 JP 2004526459A5 JP 2002589661 A JP2002589661 A JP 2002589661A JP 2002589661 A JP2002589661 A JP 2002589661A JP 2004526459 A5 JP2004526459 A5 JP 2004526459A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphocytes
- antigen
- cells
- specific
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004698 lymphocyte Anatomy 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 108010084313 CD58 Antigens Proteins 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 102000005373 Keratin-3 Human genes 0.000 claims 1
- 108010070918 Keratin-3 Proteins 0.000 claims 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 101710094000 Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000012761 co-transfection Methods 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- -1 fibroblast Proteins 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001114 myogenic effect Effects 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 210000004116 schwann cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0106231A FR2824567B1 (fr) | 2001-05-11 | 2001-05-11 | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
| PCT/FR2002/001586 WO2002092793A1 (fr) | 2001-05-11 | 2002-05-10 | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526459A JP2004526459A (ja) | 2004-09-02 |
| JP2004526459A5 true JP2004526459A5 (https=) | 2005-12-22 |
| JP4185366B2 JP4185366B2 (ja) | 2008-11-26 |
Family
ID=8863160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589661A Expired - Fee Related JP4185366B2 (ja) | 2001-05-11 | 2002-05-10 | 抗原−特異的Ｔｒ１リンパ球を得る方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8076133B2 (https=) |
| EP (1) | EP1390474B1 (https=) |
| JP (1) | JP4185366B2 (https=) |
| AT (1) | ATE354641T1 (https=) |
| CA (1) | CA2446981C (https=) |
| DE (1) | DE60218302T2 (https=) |
| DK (1) | DK1390474T3 (https=) |
| ES (1) | ES2282425T3 (https=) |
| FR (1) | FR2824567B1 (https=) |
| WO (1) | WO2002092793A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358506B1 (en) | 1997-11-05 | 2002-03-19 | University Of Southern California | Use of cytokines and mitogens to inhibit pathological immune responses |
| WO1999048524A1 (en) | 1998-03-03 | 1999-09-30 | University Of Southern California | Use of cytokines and mitogens to inhibit graft versus host disease |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| CA2469800A1 (en) * | 2001-12-21 | 2003-07-24 | University Of Southern California | Methods for the induction of professional and cytokine-producing regulatory cells |
| WO2003057171A2 (en) * | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
| US7745140B2 (en) * | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| US7638326B2 (en) * | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| AU2003292137A1 (en) * | 2002-11-29 | 2004-06-23 | Maria Grazia Roncarolo | Rapamycin and il-10 for the treatment of immune diseases |
| FR2852967B1 (fr) * | 2003-03-26 | 2007-12-07 | Txcell | Procede d'obtention de cellules dendritiques et de cellules t |
| FR2856700B1 (fr) * | 2003-06-24 | 2007-06-08 | Txcell | Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications |
| US20070275005A1 (en) * | 2003-11-12 | 2007-11-29 | Tx-Cell | Use of Lipopeptides for Activating T Lymphocytes Through the Skin |
| AU2005250408B2 (en) | 2004-05-27 | 2010-09-23 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| CA2575689C (en) * | 2004-08-11 | 2013-04-02 | Txcell | Tr1 cells for use in atherosclerosis |
| EP1812563B1 (en) * | 2004-10-29 | 2013-04-10 | Benaroya Research Institute at Virginia Mason | Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use |
| EP1712615A1 (en) * | 2005-04-15 | 2006-10-18 | Txcell | In vitro production of a cell population using feeder cells |
| CN101355965A (zh) | 2005-06-08 | 2009-01-28 | 达纳－法伯癌症研究院 | 通过抑制程序性细胞死亡1（pd-1）途经治疗持续性感染和癌症的方法及组合物 |
| ES2368152T3 (es) * | 2005-07-01 | 2011-11-14 | Txcell S.A. | Obtención de células tr1 específicas de antígenos de los alimentos o de autoantígenos a partir de una población de leucocitos o pbmc. |
| US8852581B2 (en) * | 2005-08-31 | 2014-10-07 | Ith Immune Therapy Holdings Ab | Treatment of inflammatory bowel disease |
| GB0603081D0 (en) * | 2006-02-15 | 2006-03-29 | Dynal Biotech Asa Oslo | Method |
| CA2665568C (en) * | 2006-10-04 | 2018-01-09 | Janssen Pharmaceutica, N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| EA201000131A1 (ru) * | 2007-08-02 | 2010-08-30 | АйЭсЭс ИММЬЮН СИСТЕМ СТИМУЛЕЙШН АБ | Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника |
| EP2050814A1 (en) | 2007-10-17 | 2009-04-22 | Txcell | Compositions for treating multiple sclerosis |
| US20100247577A1 (en) * | 2007-10-17 | 2010-09-30 | Txcell | Tr1 cells, mesenchymal stem cells and uses thereof |
| EP2062970A1 (en) * | 2007-11-26 | 2009-05-27 | Txcell | Compositions for treating an intestinal inflammatory condition |
| PL2113254T3 (pl) | 2008-04-28 | 2013-01-31 | Txcell | Kompozycje do leczenia autoimmunologicznego stanu zapalnego |
| EP2113560A1 (en) * | 2008-04-28 | 2009-11-04 | TXCell | Compositions for treating an arthritic condition |
| CA2744449C (en) | 2008-11-28 | 2019-01-29 | Emory University | Methods for the treatment of infections and tumors |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| EP2221364A1 (en) * | 2009-02-23 | 2010-08-25 | TXCell | Compositions for treating an allergic or asthmatic condition |
| EP2412802A1 (en) * | 2010-07-29 | 2012-02-01 | TXCell | IL-13 producing TR1-like cells and use thereof |
| EP2439534A1 (en) * | 2010-10-08 | 2012-04-11 | TXCell | Method for assessing the efficacy of a TR1 cell therapy in asubject |
| WO2012131419A1 (en) | 2011-03-25 | 2012-10-04 | Txcell | Method for using regulatory t cells in therapy |
| EP2982746A1 (en) | 2014-08-07 | 2016-02-10 | TXCell | Regulatory T cells with therapeutic potential |
| AU2019269601A1 (en) | 2018-05-17 | 2020-11-26 | Regents Of The University Of Minnesota | Drug-resistant immune cells and methods of use thereof |
| WO2019237378A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 一种将CD274基因定点整合至Jurkat细胞的方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277635B1 (en) * | 1992-03-04 | 2001-08-21 | Schering Corporation | Use of interleukin-10 to produce a population of suppressor cells |
| JP2000505650A (ja) * | 1996-02-08 | 2000-05-16 | アメリカ合衆国 | 樹状突起細胞を形質転換し、そしてｔ細胞を活性化するための方法及び組成物 |
| ATE347588T1 (de) * | 1996-05-23 | 2006-12-15 | Scripps Research Inst | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
| US6746670B2 (en) * | 2000-08-15 | 2004-06-08 | Schering Corporation | Regulatory T cells; methods |
| US6670146B2 (en) * | 2000-10-04 | 2003-12-30 | Schering Corporation | Regulatory T cells; methods |
-
2001
- 2001-05-11 FR FR0106231A patent/FR2824567B1/fr not_active Expired - Fee Related
-
2002
- 2002-05-10 US US10/477,671 patent/US8076133B2/en not_active Expired - Fee Related
- 2002-05-10 WO PCT/FR2002/001586 patent/WO2002092793A1/fr not_active Ceased
- 2002-05-10 EP EP02740789A patent/EP1390474B1/fr not_active Expired - Lifetime
- 2002-05-10 CA CA2446981A patent/CA2446981C/fr not_active Expired - Fee Related
- 2002-05-10 ES ES02740789T patent/ES2282425T3/es not_active Expired - Lifetime
- 2002-05-10 DK DK02740789T patent/DK1390474T3/da active
- 2002-05-10 JP JP2002589661A patent/JP4185366B2/ja not_active Expired - Fee Related
- 2002-05-10 AT AT02740789T patent/ATE354641T1/de not_active IP Right Cessation
- 2002-05-10 DE DE60218302T patent/DE60218302T2/de not_active Expired - Lifetime
-
2007
- 2007-10-30 US US11/928,189 patent/US20080233095A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004526459A5 (https=) | ||
| EP1390474B1 (fr) | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene | |
| US20230310562A1 (en) | Antigen presenting scaffolds for immune-cell manipulation | |
| Enk et al. | Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. | |
| Hauser et al. | Activation and expansion of hapten-and protein-specific T helper cells from nonsensitized mice. | |
| Moser et al. | γδ T-APCs: a novel tool for immunotherapy? | |
| JP2021502414A5 (https=) | ||
| JP2006020648A5 (https=) | ||
| Northrop et al. | CD8+ T-cell memory: only the good ones last | |
| US8603815B2 (en) | CD4+ CD25− T cells and Tr1-like regulatory T cells | |
| JP2002539805A5 (https=) | ||
| Xia et al. | Prevention of allograft rejection by amplification of Foxp3+ CD4+ CD25+ regulatory T cells | |
| Sordi et al. | Therapeutic plasticity of stem cells and allograft tolerance | |
| Li et al. | Artificial antigen-presenting cells: the booster for the obtaining of functional adoptive cells | |
| Wang et al. | Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapy | |
| IL273698B2 (en) | Methods for selectively expanding cells expressing a tcr with a murine constant region | |
| Freudenthal et al. | Human blood dendritic cells | |
| JP2002500872A5 (https=) | ||
| Spits et al. | Cloning of human T and natural killer cells | |
| Moberg | An appreciation of Ralph Marvin Steinman (1943–2011) | |
| Arthur et al. | Dental pulp stem cells | |
| EP1391504A1 (en) | CD4+ CD25- T cells and Tr1-like regulatory T cells | |
| Kuncorojakti | Establishment of encapsulated human dental pulp stem cell-derived insulin producing cells (hDPSC-IPCs) for translational stem cell based diabetes therapy | |
| Heeger | What's new and what's hot in transplantation: basic science ATC 2003 | |
| Yingxi et al. | Strategies for Generating Regulatory Dendritic Cells and the Clinical Application of Immune Tolerance. |