EA201000131A1 - Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника - Google Patents

Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника

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Publication number
EA201000131A1
EA201000131A1 EA201000131A EA201000131A EA201000131A1 EA 201000131 A1 EA201000131 A1 EA 201000131A1 EA 201000131 A EA201000131 A EA 201000131A EA 201000131 A EA201000131 A EA 201000131A EA 201000131 A1 EA201000131 A1 EA 201000131A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sample
ibd
helper cells
significantly increased
suspension
Prior art date
Application number
EA201000131A
Other languages
English (en)
Inventor
Магнус Тёрн
Ола Винквист
Original Assignee
АйЭсЭс ИММЬЮН СИСТЕМ СТИМУЛЕЙШН АБ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by АйЭсЭс ИММЬЮН СИСТЕМ СТИМУЛЕЙШН АБ filed Critical АйЭсЭс ИММЬЮН СИСТЕМ СТИМУЛЕЙШН АБ
Publication of EA201000131A1 publication Critical patent/EA201000131A1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Способ различения активного и неактивного воспалительного заболевания кишечника (IBD) в образце слизистой оболочки желудочно-кишечного тракта или образце из сторожевого лимфатического узла, дренирующего слизистую оболочку желудочно-кишечного тракта, включающий приготовление суспензии отдельных клеток из указанного образца; анализ указанной суспензии в отношении экспрессии маркера активации воспаления CD69 на CD4+ Т-клетках-хелперах с использованием непосредственно меченного флуоресцентной меткой антитела к CD69; сравнение количества Т-клеток-хелперов, экспрессирующих CD69, в указанном образце с количеством, полученным из соответствующего образца от здорового человека, причем значительно повышенный уровень Т-клеток-хелперов, экспрессирующих CD69, означает наличие активного IBD, и менее значительно повышенный уровень Т-клеток-хелперов означает наличие неактивного IBD. Также раскрыты способы различения неспецифического язвенного колита (НЯК) и болезни Крона (БК), выявления НЯК и БК и определения чувствительности пациента с IBD к лечению стероидами.
EA201000131A 2007-08-02 2008-07-29 Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника EA201000131A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0701807 2007-08-02
PCT/SE2008/000464 WO2009017444A2 (en) 2007-08-02 2008-07-29 Diagnosis, staging and monitoring of inflammatory bowel disease

Publications (1)

Publication Number Publication Date
EA201000131A1 true EA201000131A1 (ru) 2010-08-30

Family

ID=40305076

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000131A EA201000131A1 (ru) 2007-08-02 2008-07-29 Диагностика, определение стадии и мониторинг воспалительного заболевания кишечника

Country Status (10)

Country Link
US (1) US20110081649A1 (ru)
EP (1) EP2185936A4 (ru)
JP (1) JP2010535336A (ru)
KR (1) KR20100063052A (ru)
CN (1) CN101815945A (ru)
AU (1) AU2008283077A1 (ru)
CA (1) CA2695360A1 (ru)
EA (1) EA201000131A1 (ru)
WO (1) WO2009017444A2 (ru)
ZA (1) ZA201001486B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG165328A1 (en) 2005-08-31 2010-10-28 Ith Immune Therapy Holdings Ab Treatment of inflammatory bowel disease
ES2809171T3 (es) 2008-01-18 2021-03-03 Harvard College Métodos para detectar distintivos de enfermedades o afecciones en fluidos corporales
WO2011127351A1 (en) * 2010-04-09 2011-10-13 Exagen Diagnostics, Inc. Biomarkers for ulcerative colitis and crohn's disease
JP5837761B2 (ja) * 2010-05-12 2015-12-24 イーエヌ大塚製薬株式会社 クローン病の活動性の分類
CN103124795A (zh) 2010-07-23 2013-05-29 哈佛大学校长及研究员协会 利用吞噬细胞检测疾病或病症的方法
CA2806304A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
SG10201505723UA (en) 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
IT1406051B1 (it) * 2010-08-05 2014-02-06 D M G Italia S R L Uso di hmgb1 come marcatore biologico di infiammazione intestinale umana, metodo non invasivo per la sua rilevazione in campioni fecali e kit relativo.
AU2013261162A1 (en) * 2012-05-18 2014-12-04 Igr-Institut Gustave Roussy Characterization of biological tissues at a cellular level using red and far-red fluorescent dyes
GB201223223D0 (en) 2012-12-21 2013-02-06 Norinnova Technology Transfer As Inflammatory bowel disease
WO2014164366A1 (en) 2013-03-09 2014-10-09 Harry Stylli Methods of detecting cancer
EP2965086A4 (en) 2013-03-09 2017-02-08 Harry Stylli Methods of detecting prostate cancer
WO2015175861A1 (en) * 2014-05-16 2015-11-19 Amgen Inc. Assay for detecting th1 and th2 cell populations
EP3693742B1 (en) 2014-09-11 2022-04-06 Harry Stylli Methods of detecting prostate cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746670B2 (en) * 2000-08-15 2004-06-08 Schering Corporation Regulatory T cells; methods
FR2824567B1 (fr) * 2001-05-11 2003-08-08 Inst Nat Sante Rech Med Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene
JP4395070B2 (ja) * 2002-06-25 2010-01-06 インデックス・ダイアグノスティックス・アクチエボラーグ 潰瘍性大腸炎を診断するための方法およびキット
WO2005009339A2 (en) * 2003-05-30 2005-02-03 Pathway Diagnostics Corporation, Inc. (a Delaware Corporation) Inflammatory bowel diseases
US8449489B2 (en) * 2006-05-12 2013-05-28 Ith Immune Therapy Holdings Ab Method and means for treating inflammatory bowel disease
CN101899587B (zh) * 2006-07-21 2012-07-04 株式会社神户制钢所 电气电子零件用铜合金板
US7877602B2 (en) * 2007-07-27 2011-01-25 International Business Machines Corporation Transparent aware data transformation at file system level for efficient encryption and integrity validation of network files

Also Published As

Publication number Publication date
AU2008283077A1 (en) 2009-02-05
ZA201001486B (en) 2013-05-29
JP2010535336A (ja) 2010-11-18
CA2695360A1 (en) 2009-02-05
WO2009017444A3 (en) 2009-03-19
KR20100063052A (ko) 2010-06-10
EP2185936A4 (en) 2010-08-04
WO2009017444A2 (en) 2009-02-05
CN101815945A (zh) 2010-08-25
EP2185936A2 (en) 2010-05-19
US20110081649A1 (en) 2011-04-07

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