JP2004525983A5 - - Google Patents
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- Publication number
- JP2004525983A5 JP2004525983A5 JP2002583415A JP2002583415A JP2004525983A5 JP 2004525983 A5 JP2004525983 A5 JP 2004525983A5 JP 2002583415 A JP2002583415 A JP 2002583415A JP 2002583415 A JP2002583415 A JP 2002583415A JP 2004525983 A5 JP2004525983 A5 JP 2004525983A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- those
- preferred compounds
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims description 2
- -1 indol-4-yl Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 description 10
- KVFQMAZOBTXCAZ-UHFFFAOYSA-N 3,4-Hexanedione Chemical group CCC(=O)C(=O)CC KVFQMAZOBTXCAZ-UHFFFAOYSA-N 0.000 description 2
- JPBHXUJZGVAFDP-UHFFFAOYSA-N 6-(2-bromoethyl)-2,3-diethylquinoxaline Chemical group C1=C(CCBr)C=C2N=C(CC)C(CC)=NC2=C1 JPBHXUJZGVAFDP-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- YLVACWCCJCZITJ-UHFFFAOYSA-N 1,4-dioxane-2,3-diol Chemical compound OC1OCCOC1O YLVACWCCJCZITJ-UHFFFAOYSA-N 0.000 description 1
- NIWKKMCAOZJRRT-UHFFFAOYSA-N 2,3-diethyl-6-[2-[4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridin-1-yl]ethyl]quinoxaline Chemical compound C1=C2N=C(CC)C(CC)=NC2=CC=C1CCN(CC=1)CCC=1C1=CC=CC(C(F)(F)F)=C1 NIWKKMCAOZJRRT-UHFFFAOYSA-N 0.000 description 1
- IETGHNBXRLPDNJ-UHFFFAOYSA-N 2-(2,3-diethylquinoxalin-6-yl)ethanol Chemical compound C1=C(CCO)C=C2N=C(CC)C(CC)=NC2=C1 IETGHNBXRLPDNJ-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0105360A FR2823748B1 (fr) | 2001-04-20 | 2001-04-20 | Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR0105362A FR2823750B1 (fr) | 2001-04-20 | 2001-04-20 | Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenant |
| PCT/FR2002/001343 WO2002085888A1 (fr) | 2001-04-20 | 2002-04-19 | Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525983A JP2004525983A (ja) | 2004-08-26 |
| JP2004525983A5 true JP2004525983A5 (https=) | 2009-06-18 |
| JP4324382B2 JP4324382B2 (ja) | 2009-09-02 |
Family
ID=26212980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002583415A Expired - Fee Related JP4324382B2 (ja) | 2001-04-20 | 2002-04-19 | テトラヒドロピリジル−アルキル−複素環、その製造方法およびそれを含む医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7186720B2 (https=) |
| EP (1) | EP1383762B1 (https=) |
| JP (1) | JP4324382B2 (https=) |
| AT (1) | ATE365162T1 (https=) |
| DE (1) | DE60220779T2 (https=) |
| WO (1) | WO2002085888A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2831166B1 (fr) * | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| FR2883285B1 (fr) * | 2005-03-17 | 2007-05-18 | Sanofi Aventis Sa | Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique |
| US7662824B2 (en) * | 2005-03-18 | 2010-02-16 | Janssen Pharmaceutica Nv | Acylhydrazones as kinase modulators |
| HRP20170103T1 (hr) | 2005-12-21 | 2017-03-24 | Janssen Pharmaceutica N.V. | Triazolopiridazini kao modulatori tirozin kinaze |
| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| US8497269B2 (en) | 2008-10-10 | 2013-07-30 | Amgen Inc. | Phthalazine compounds as p38 map kinase modulators and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421641A1 (de) * | 1984-06-09 | 1985-12-12 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
| FR2736053B1 (fr) * | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| FR2762514B1 (fr) | 1997-04-29 | 1999-10-22 | Sanofi Sa | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation |
-
2002
- 2002-04-19 US US10/475,460 patent/US7186720B2/en not_active Expired - Fee Related
- 2002-04-19 WO PCT/FR2002/001343 patent/WO2002085888A1/fr not_active Ceased
- 2002-04-19 JP JP2002583415A patent/JP4324382B2/ja not_active Expired - Fee Related
- 2002-04-19 DE DE60220779T patent/DE60220779T2/de not_active Expired - Lifetime
- 2002-04-19 AT AT02727676T patent/ATE365162T1/de not_active IP Right Cessation
- 2002-04-19 EP EP02727676A patent/EP1383762B1/fr not_active Expired - Lifetime
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