JP2004525952A5 - - Google Patents
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- Publication number
- JP2004525952A5 JP2004525952A5 JP2002579468A JP2002579468A JP2004525952A5 JP 2004525952 A5 JP2004525952 A5 JP 2004525952A5 JP 2002579468 A JP2002579468 A JP 2002579468A JP 2002579468 A JP2002579468 A JP 2002579468A JP 2004525952 A5 JP2004525952 A5 JP 2004525952A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- benzyl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000004043 oxo group Chemical group O=* 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 11
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 hydroxy, Phenyl Chemical group 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28264201P | 2001-04-09 | 2001-04-09 | |
| PCT/US2002/006662 WO2002081480A1 (en) | 2001-04-09 | 2002-03-27 | Compounds and pharmaceutical compositions for inhibiting mrp1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525952A JP2004525952A (ja) | 2004-08-26 |
| JP2004525952A5 true JP2004525952A5 (enExample) | 2005-12-22 |
Family
ID=23082449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579468A Pending JP2004525952A (ja) | 2001-04-09 | 2002-03-27 | Ｍｒｐ１を阻害するための化合物および医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7101891B2 (enExample) |
| EP (1) | EP1392701A1 (enExample) |
| JP (1) | JP2004525952A (enExample) |
| CA (1) | CA2442141A1 (enExample) |
| WO (1) | WO2002081480A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| JP2009508963A (ja) * | 2005-09-21 | 2009-03-05 | インサイト・コーポレイション | アミド化合物および医薬組成物としてのその使用 |
| WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6369070B1 (en) * | 1998-04-08 | 2002-04-09 | Eli Lilly And Company | Methods for inhibiting mrp1 |
| US6743794B2 (en) * | 1999-12-22 | 2004-06-01 | Eli Lilly And Company | Methods and compounds for inhibiting MRP1 |
-
2002
- 2002-03-27 WO PCT/US2002/006662 patent/WO2002081480A1/en not_active Ceased
- 2002-03-27 EP EP02723331A patent/EP1392701A1/en not_active Withdrawn
- 2002-03-27 JP JP2002579468A patent/JP2004525952A/ja active Pending
- 2002-03-27 CA CA002442141A patent/CA2442141A1/en not_active Abandoned
- 2002-03-27 US US10/473,236 patent/US7101891B2/en not_active Expired - Fee Related
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