JP2004525928A - ニコチン含有経口剤形 - Google Patents

ニコチン含有経口剤形 Download PDF

Info

Publication number
JP2004525928A
JP2004525928A JP2002574739A JP2002574739A JP2004525928A JP 2004525928 A JP2004525928 A JP 2004525928A JP 2002574739 A JP2002574739 A JP 2002574739A JP 2002574739 A JP2002574739 A JP 2002574739A JP 2004525928 A JP2004525928 A JP 2004525928A
Authority
JP
Japan
Prior art keywords
nicotine
dosage form
active
sugar alcohol
oral administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002574739A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004525928A5 (https=
Inventor
ジョン・リウ
スタンリー・ジェイ・レッチ
スチュアート・プラットカウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JP2004525928A publication Critical patent/JP2004525928A/ja
Publication of JP2004525928A5 publication Critical patent/JP2004525928A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2002574739A 2001-03-26 2002-03-22 ニコチン含有経口剤形 Pending JP2004525928A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27860601P 2001-03-26 2001-03-26
PCT/US2002/008914 WO2002076211A1 (en) 2001-03-26 2002-03-22 Nicotine-containing oral dosage form

Publications (2)

Publication Number Publication Date
JP2004525928A true JP2004525928A (ja) 2004-08-26
JP2004525928A5 JP2004525928A5 (https=) 2005-12-22

Family

ID=23065632

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002574739A Pending JP2004525928A (ja) 2001-03-26 2002-03-22 ニコチン含有経口剤形

Country Status (11)

Country Link
EP (1) EP1372392A4 (https=)
JP (1) JP2004525928A (https=)
CN (2) CN101301275A (https=)
AR (1) AR033444A1 (https=)
AU (1) AU2002252470B2 (https=)
BR (1) BR0208382A (https=)
CA (1) CA2440713A1 (https=)
MX (1) MXPA03008762A (https=)
NZ (1) NZ528167A (https=)
PL (1) PL364621A1 (https=)
WO (1) WO2002076211A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013528588A (ja) * 2010-05-07 2013-07-11 ニコノバム・ユー・エス・エイ・インコーポレイテツド ニコチン含有医薬組成物
JP2014526278A (ja) * 2011-09-22 2014-10-06 アール・ジエイ・レイノルズ・タバコ・カンパニー 半透明無煙タバコ製品
JP2015516153A (ja) * 2012-04-17 2015-06-11 アール・ジエイ・レイノルズ・タバコ・カンパニー 再融解摂取製品
JP2022535586A (ja) * 2019-06-07 2022-08-09 エヌシーピー ネクストジェン アクティーゼルスカブ ニコチンパウチ組成物
JP2024513464A (ja) * 2021-04-06 2024-03-25 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 口腔用製品に含有させるための噴霧乾燥ニコチン
JP2024515559A (ja) * 2021-04-06 2024-04-10 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー カプセル化ニコチン顆粒及びその調製方法

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253307A1 (en) * 2003-02-04 2004-12-16 Brian Hague Sugar-free oral transmucosal solid dosage forms and uses thereof
IL155666A (en) 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
EP1648421B1 (en) * 2003-07-24 2017-10-18 GlaxoSmithKline LLC Orally dissolving films
GB0320854D0 (en) 2003-09-05 2003-10-08 Arrow No 7 Ltd Buccal drug delivery
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8469036B2 (en) 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
BRPI0514283A (pt) * 2004-08-11 2008-06-10 Cadbury Adams Usa Llc composições para aquecimento e sistemas de liberação para as mesmas
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
JP5254616B2 (ja) 2004-09-13 2013-08-07 クロノ セラピューティクス、インコーポレイテッド 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達
MX2009005671A (es) * 2006-12-01 2009-06-08 Cima Labs Inc Forma de dosificacion de nicotina transmucosal oral.
GB2468424B (en) * 2007-04-02 2011-11-09 Parkinson S Inst Methods and compositions for reduction of side effects of therapeutic treatments
EP2322168A1 (en) 2007-04-02 2011-05-18 Parkinson's Institute Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments
DE102008012015A1 (de) * 2008-03-01 2009-09-10 Südzucker AG Mannheim/Ochsenfurt Verbesserte Isomalt-haltige Komprimate und Verfahren zu ihrer Herstellung
BR112012020731A2 (pt) * 2010-02-18 2016-04-26 Jatin Vasant Thakkar pastilhas gelatinosas suaves com nicotina.
UA112974C2 (uk) * 2010-09-16 2016-11-25 Джеі. Бі. Кемікалс Енд Фармасьютікалс Лімітид Нікотиновмісна композиція (варіанти)
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9629392B2 (en) 2011-09-22 2017-04-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9084439B2 (en) 2011-09-22 2015-07-21 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
TW201507726A (zh) * 2013-05-10 2015-03-01 Glaxosmithkline Llc 菸鹼菱形錠配製物
CN104132895B (zh) * 2014-07-08 2017-08-25 国家烟草质量监督检验中心 适用于连续流动法测定烟草及烟草制品中总植物碱的缓冲体系
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
SE541358C2 (en) * 2017-05-30 2019-08-13 Enorama Pharma Ab Nicotine-containing chewing gum compositions
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited METHODS AND SYSTEMS FOR DRUG DELIVERY
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
US20230053622A1 (en) * 2020-01-15 2023-02-23 Mcneil Ab Lozenge
USD1081739S1 (en) 2021-04-06 2025-07-01 Altria Client Services Llc Die for gum forming
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5549906A (en) * 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
DE19536394A1 (de) * 1995-09-29 1997-04-03 Basf Ag Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze
DE19639342C2 (de) * 1996-09-25 1998-07-16 Suedzucker Ag Kaugummi, enthaltend ein Süßungsmittel
US6322806B1 (en) * 1999-04-06 2001-11-27 Wm. Wrigley Jr. Company Over-coated chewing gum formulations including tableted center

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013528588A (ja) * 2010-05-07 2013-07-11 ニコノバム・ユー・エス・エイ・インコーポレイテツド ニコチン含有医薬組成物
JP2014526278A (ja) * 2011-09-22 2014-10-06 アール・ジエイ・レイノルズ・タバコ・カンパニー 半透明無煙タバコ製品
JP2015516153A (ja) * 2012-04-17 2015-06-11 アール・ジエイ・レイノルズ・タバコ・カンパニー 再融解摂取製品
JP2022535586A (ja) * 2019-06-07 2022-08-09 エヌシーピー ネクストジェン アクティーゼルスカブ ニコチンパウチ組成物
JP7682812B2 (ja) 2019-06-07 2025-05-26 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチンパウチ組成物
JP2024513464A (ja) * 2021-04-06 2024-03-25 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 口腔用製品に含有させるための噴霧乾燥ニコチン
JP2024515559A (ja) * 2021-04-06 2024-04-10 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー カプセル化ニコチン顆粒及びその調製方法
JP7789800B2 (ja) 2021-04-06 2025-12-22 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー カプセル化ニコチン顆粒及びその調製方法
JP7789799B2 (ja) 2021-04-06 2025-12-22 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 口腔用製品に含有させるための噴霧乾燥ニコチン

Also Published As

Publication number Publication date
WO2002076211A1 (en) 2002-10-03
PL364621A1 (en) 2004-12-13
CA2440713A1 (en) 2002-10-03
CN1553771A (zh) 2004-12-08
BR0208382A (pt) 2004-06-15
MXPA03008762A (es) 2004-02-18
EP1372392A4 (en) 2004-06-23
CN101301275A (zh) 2008-11-12
AR033444A1 (es) 2003-12-17
AU2002252470B2 (en) 2008-05-22
NZ528167A (en) 2005-04-29
EP1372392A1 (en) 2004-01-02

Similar Documents

Publication Publication Date Title
AU2002252470B2 (en) Nicotine-containing oral dosage form
US20040101543A1 (en) Nicotine-containing oral dosage form
AU2003267268B2 (en) Modified release oral dosage form
AU2002252470A1 (en) Nicotine-containing oral dosage form
CA2652499C (en) Pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent
JP2024170422A (ja) 多層状ニコチン含有医薬組成物
KR101414063B1 (ko) 완충제로서 트로메타몰을 포함하는, 니코틴의 구강내 전달을 위한 피복된 약제학적 제품
AU776019B2 (en) Medicated chewing gum delivery system for nicotine
US20100124560A1 (en) Multi portion intra-oral dosage form and use thereof
KR20100017820A (ko) 아미노산으로 완충된 경구 니코틴 제형
NZ575073A (en) Medicinal delivery system and related methods comprising a nicotine coated on a saliva-soluble powder such as sorbitol
NZ529780A (en) A coated nicotine-containing chewing gum, manufacture and use thereof
CA2685456A1 (en) Coated oral nicotine formulation buffered with amino acid
EP1429770B1 (en) New formulations and use thereof
AU2002334523A1 (en) New formulations and use thereof
AU2008202048A1 (en) Nicotine-containing oral dosage form
AU2012241150B2 (en) Medicinal delivery system and related methods
JUNO et al. PHARMACEUTICAL SCIENCES

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050308

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050308

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081111

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090205

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090213

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090512