JP2004525888A5 - - Google Patents

Info

Publication number

JP2004525888A5

JP2004525888A5 JP2002559370A JP2002559370A JP2004525888A5 JP 2004525888 A5 JP2004525888 A5 JP 2004525888A5 JP 2002559370 A JP2002559370 A JP 2002559370A JP 2002559370 A JP2002559370 A JP 2002559370A JP 2004525888 A5 JP2004525888 A5 JP 2004525888A5

Authority

JP

Japan

Prior art keywords

group

methoxy

phenylsulfonyl

integer

substituted

Prior art date

2002-01-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims description 13
• -1 4-methoxy-phenylsulfonyl group Chemical group 0.000 claims 12
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 125000004432 carbon atoms Chemical group C* 0.000 claims 7
• 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 7
• 239000003112 inhibitor Substances 0.000 claims 5
• 230000002401 inhibitory effect Effects 0.000 claims 5
• 125000001424 substituent group Chemical group 0.000 claims 5
• 125000003118 aryl group Chemical group 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 229920001515 polyalkylene glycol Polymers 0.000 claims 3
• 101700006801 THBI Proteins 0.000 claims 2
• 125000003710 aryl alkyl group Chemical group 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 230000001737 promoting Effects 0.000 claims 2
• 239000003868 thrombin inhibitor Substances 0.000 claims 2
• NKCXQMYPWXSLIZ-PSRDDEIFSA-N (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-m Chemical compound O=C([C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O NKCXQMYPWXSLIZ-PSRDDEIFSA-N 0.000 claims 1
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• 230000036826 Excretion Effects 0.000 claims 1
• 210000003722 Extracellular Fluid Anatomy 0.000 claims 1
• 210000003734 Kidney Anatomy 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 108090000190 Thrombin Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 125000004103 aminoalkyl group Chemical group 0.000 claims 1
• 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 1
• 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 238000004090 dissolution Methods 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
• 230000029142 excretion Effects 0.000 claims 1
• 125000003827 glycol group Chemical group 0.000 claims 1
• 125000005842 heteroatoms Chemical group 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
• 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
• 230000000268 renotropic Effects 0.000 claims 1
• 229960004072 thrombin Drugs 0.000 claims 1
• 0 *OC([C@](CCC1)N1C([C@@](CC1CCCCC1)NCC(NCC*O)=O)=O)=O Chemical compound *OC([C@](CCC1)N1C([C@@](CC1CCCCC1)NCC(NCC*O)=O)=O)=O 0.000 description 3
• LDDXTZJQVINROX-UHFFFAOYSA-N CNCc(cc1)ccc1C(N)=N Chemical compound CNCc(cc1)ccc1C(N)=N LDDXTZJQVINROX-UHFFFAOYSA-N 0.000 description 2
• MSPORBDQRNSRAM-UHFFFAOYSA-N CNCC(CC1)CCN1C(N)=N Chemical compound CNCC(CC1)CCN1C(N)=N MSPORBDQRNSRAM-UHFFFAOYSA-N 0.000 description 1