JP2004525154A5 - - Google Patents
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- Publication number
- JP2004525154A5 JP2004525154A5 JP2002577781A JP2002577781A JP2004525154A5 JP 2004525154 A5 JP2004525154 A5 JP 2004525154A5 JP 2002577781 A JP2002577781 A JP 2002577781A JP 2002577781 A JP2002577781 A JP 2002577781A JP 2004525154 A5 JP2004525154 A5 JP 2004525154A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- cycloalkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- 239000001257 hydrogen Substances 0.000 claims 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 28
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 26
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000002877 alkyl aryl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000002452 interceptive effect Effects 0.000 claims 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 6
- 208000012659 Joint disease Diseases 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 208000036487 Arthropathies Diseases 0.000 claims 5
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 206010003246 arthritis Diseases 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 4
- 150000003536 tetrazoles Chemical class 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 206010006448 Bronchiolitis Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 208000002574 reactive arthritis Diseases 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 206010000599 Acromegaly Diseases 0.000 claims 1
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000018565 Hemochromatosis Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 206010020877 Hypertrophic osteoarthropathy Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 201000002661 Spondylitis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000002240 Tennis Elbow Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 208000021240 acute bronchiolitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 208000002849 chondrocalcinosis Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 208000034737 hemoglobinopathy Diseases 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 201000004990 juvenile ankylosing spondylitis Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000011201 multicentric reticulohistiocytosis Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 230000003156 vasculitic effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27930001P | 2001-03-28 | 2001-03-28 | |
| PCT/US2002/006636 WO2002079154A1 (en) | 2001-03-28 | 2002-03-15 | Substituted carbazoles as inhibitors of spla2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525154A JP2004525154A (ja) | 2004-08-19 |
| JP2004525154A5 true JP2004525154A5 (enExample) | 2006-01-05 |
Family
ID=23068394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002577781A Pending JP2004525154A (ja) | 2001-03-28 | 2002-03-15 | ｓＰＬＡ２インヒビターとしての置換カルバゾール |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6933313B2 (enExample) |
| EP (1) | EP1395554B1 (enExample) |
| JP (1) | JP2004525154A (enExample) |
| AT (1) | ATE353876T1 (enExample) |
| CA (1) | CA2441077A1 (enExample) |
| DE (1) | DE60218155D1 (enExample) |
| WO (1) | WO2002079154A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1852433B1 (en) | 2004-10-29 | 2011-11-23 | Zeria Pharmaceutical Co., Ltd. | Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof |
| US8580795B2 (en) | 2009-01-22 | 2013-11-12 | Orchid Chemicals & Pharmaceuticals Limited | Heterocyclic compounds as phosphodiesterase inhibitors |
| CN107233337A (zh) | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| WO2013072915A1 (en) * | 2011-11-15 | 2013-05-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Tricyclic compounds, compositions comprising them and uses thereof |
| CN102727752A (zh) * | 2012-06-19 | 2012-10-17 | 卞毓平 | 五虎丹胶囊在制备治疗痛风药物中的应用 |
| US9492460B2 (en) * | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| US10307406B2 (en) | 2013-08-31 | 2019-06-04 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for re-activating Epstein-Barr virus and screening compounds therefor |
| WO2016203468A1 (en) | 2015-06-15 | 2016-12-22 | Raziel Therapeutics Ltd. | Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420289A (en) | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| IL129484A0 (en) * | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| WO2001021587A2 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors |
| WO2001049662A2 (en) * | 2000-01-07 | 2001-07-12 | Eli Lilly And Company | Carbazole derivatives as inhibitors of spla2 |
-
2002
- 2002-03-15 DE DE60218155T patent/DE60218155D1/de not_active Expired - Fee Related
- 2002-03-15 CA CA002441077A patent/CA2441077A1/en not_active Abandoned
- 2002-03-15 US US10/467,965 patent/US6933313B2/en not_active Expired - Fee Related
- 2002-03-15 AT AT02709779T patent/ATE353876T1/de not_active IP Right Cessation
- 2002-03-15 JP JP2002577781A patent/JP2004525154A/ja active Pending
- 2002-03-15 EP EP02709779A patent/EP1395554B1/en not_active Expired - Lifetime
- 2002-03-15 WO PCT/US2002/006636 patent/WO2002079154A1/en not_active Ceased
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