JP2004525123A5 - - Google Patents

Info

Publication number

JP2004525123A5

JP2004525123A5 JP2002571034A JP2002571034A JP2004525123A5 JP 2004525123 A5 JP2004525123 A5 JP 2004525123A5 JP 2002571034 A JP2002571034 A JP 2002571034A JP 2002571034 A JP2002571034 A JP 2002571034A JP 2004525123 A5 JP2004525123 A5 JP 2004525123A5

Authority

JP

Japan

Prior art keywords

layer

peptide

pharmaceutical composition

lowering agent

dosage form

Prior art date

2002-03-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 20
• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 239000003795 chemical substances by application Substances 0.000 claims 17
• 239000002702 enteric coating Substances 0.000 claims 13
• 238000009505 enteric coating Methods 0.000 claims 13
• 238000000576 coating method Methods 0.000 claims 12
• 239000002552 dosage form Substances 0.000 claims 12
• 239000011248 coating agent Substances 0.000 claims 10
• 239000000463 material Substances 0.000 claims 10
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 8
• 238000010521 absorption reaction Methods 0.000 claims 8
• 239000003623 enhancer Substances 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 230000015572 biosynthetic process Effects 0.000 claims 5
• 230000003993 interaction Effects 0.000 claims 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims 4
• 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 4
• 235000017557 sodium bicarbonate Nutrition 0.000 claims 4
• 239000004094 surface-active agent Substances 0.000 claims 4
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 3
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 3
• 229960003773 calcitonin (salmon synthetic) Drugs 0.000 claims 3
• 229960004203 carnitine Drugs 0.000 claims 3
• 239000003638 chemical reducing agent Substances 0.000 claims 3
• 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 108010068072 salmon calcitonin Proteins 0.000 claims 3
• 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
• 229960001681 croscarmellose sodium Drugs 0.000 claims 2
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
• 239000007884 disintegrant Substances 0.000 claims 2
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
• 239000008108 microcrystalline cellulose Substances 0.000 claims 2
• 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 claims 1
• 239000003613 bile acid Substances 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 210000000936 intestine Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000003904 phospholipids Chemical class 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 210000002784 stomach Anatomy 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1