JP2004525082A5 - - Google Patents

Download PDF

Info

Publication number
JP2004525082A5
JP2004525082A5 JP2002532445A JP2002532445A JP2004525082A5 JP 2004525082 A5 JP2004525082 A5 JP 2004525082A5 JP 2002532445 A JP2002532445 A JP 2002532445A JP 2002532445 A JP2002532445 A JP 2002532445A JP 2004525082 A5 JP2004525082 A5 JP 2004525082A5
Authority
JP
Japan
Prior art keywords
fifteen
amino acid
natural
cycloalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002532445A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004525082A (ja
JP4269144B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/030951 external-priority patent/WO2002028862A2/en
Publication of JP2004525082A publication Critical patent/JP2004525082A/ja
Publication of JP2004525082A5 publication Critical patent/JP2004525082A5/ja
Application granted granted Critical
Publication of JP4269144B2 publication Critical patent/JP4269144B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002532445A 2000-10-02 2001-10-02 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ Expired - Fee Related JP4269144B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23755700P 2000-10-02 2000-10-02
PCT/US2001/030951 WO2002028862A2 (en) 2000-10-02 2001-10-02 Triptolide analogs for the treatment of autoimmune and inflammatory disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008331610A Division JP2009102371A (ja) 2000-10-02 2008-12-25 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ

Publications (3)

Publication Number Publication Date
JP2004525082A JP2004525082A (ja) 2004-08-19
JP2004525082A5 true JP2004525082A5 (https=) 2008-07-17
JP4269144B2 JP4269144B2 (ja) 2009-05-27

Family

ID=22894243

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002532445A Expired - Fee Related JP4269144B2 (ja) 2000-10-02 2001-10-02 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ
JP2008331610A Pending JP2009102371A (ja) 2000-10-02 2008-12-25 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008331610A Pending JP2009102371A (ja) 2000-10-02 2008-12-25 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ

Country Status (8)

Country Link
US (3) US6777441B2 (https=)
EP (2) EP1330459B1 (https=)
JP (2) JP4269144B2 (https=)
AT (2) ATE469907T1 (https=)
AU (2) AU9654201A (https=)
CA (1) CA2424555A1 (https=)
DE (2) DE60121986T2 (https=)
WO (1) WO2002028862A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002028862A2 (en) 2000-10-02 2002-04-11 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EP2468277A1 (en) * 2002-05-31 2012-06-27 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
WO2004023984A2 (en) * 2002-09-13 2004-03-25 Smith C Steven Novel composition and method for treatment of upper respiratory conditions
TW200509958A (en) * 2003-02-14 2005-03-16 Combinatorx Inc Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
WO2005012294A1 (en) * 2003-07-30 2005-02-10 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US20050192261A1 (en) * 2003-09-15 2005-09-01 Jost-Price Edward R. Methods and reagents for the treatment of immunoinflammatory disorders
WO2005062913A2 (en) * 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en) * 2004-02-09 2009-09-16 Pharmagenesis Inc METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
WO2005084365A2 (en) * 2004-03-02 2005-09-15 Pharmagenesis, Inc. Triptolide lactone ring derivatives as immunomodulators and anticancer agents
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
WO2006012204A2 (en) * 2004-06-25 2006-02-02 Pharmagenesis, Inc. Method for treatment of inflammatory disorders using triptolide compounds
WO2006044496A2 (en) * 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
WO2007053844A2 (en) * 2005-10-31 2007-05-10 Rigel Pharmaceuticals, Inc. Compositions and methods for treating inflammatory disorders
EP2240460A4 (en) * 2008-01-07 2012-02-22 Univ Emory BRANCHED DIEPXYDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
US8147882B2 (en) 2009-09-30 2012-04-03 Leonard Lomax Herbal pain killer compositions
CN104478832B (zh) * 2015-01-05 2016-04-20 项敬来 二萜化合物，含其的药物组合物及其制备方法和应用
JP6743135B2 (ja) * 2015-09-02 2020-08-19 アッヴィ・インコーポレイテッド 抗ウィルス性テトラヒドロフラン誘導体

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1179866A (en) * 1967-09-08 1970-02-04 Agfa Gevaert Nv Photopolymerisation of Ethylenically Unsaturated Organic Compounds
US3917652A (en) * 1968-04-29 1975-11-04 Hoffmann La Roche Juvabione and derivatives thereof
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
US3816437A (en) * 1972-12-22 1974-06-11 Sandoz Ag Thieno(2,3-g)indazoles
US3957816A (en) * 1973-01-31 1976-05-18 Sandoz, Inc. Substituted naphtho pyrazoles
JPS5473766A (en) 1977-11-21 1979-06-13 Nippon Terpen Kagaku Kk Manufacture of menthofuran
GB2104516B (en) 1981-07-13 1985-12-04 Univ Brunel M-alkylphenol derivatives and their use in copper extraction
DE3219048A1 (de) 1982-05-21 1983-11-24 Basf Ag, 6700 Ludwigshafen Thermoplastische formmassen
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE3440826A1 (de) 1983-11-10 1985-05-23 Basf Ag, 6700 Ludwigshafen 1,1-ethanoretinsaeuren und ihre c(pfeil abwaerts)1(pfeil abwaerts)-c(pfeil abwaerts)4(pfeil abwaerts)-alkylester
JPS61197573A (ja) 1985-02-26 1986-09-01 Chugai Pharmaceut Co Ltd ５，６−エポキシ化トランスビタミンｄ３
JP2865211B2 (ja) 1988-09-15 1999-03-08 ファルマシア・アンド・アップジョン・カンパニー ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
DE3913310A1 (de) 1989-04-20 1990-10-25 Schering Ag Spirocyclopropane in der vitamin d-reihe
JPH03197464A (ja) 1989-12-16 1991-08-28 Basf Ag 置換アゾリルメチルシクロアルカノール及びこれを含有する殺菌剤
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
AU7570191A (en) * 1990-03-14 1991-10-10 Board Of Regents, The University Of Texas System Tripterygium wilfordii hook f extracts and components thereof for immunosuppression
US5216175A (en) * 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
US5581004A (en) * 1991-09-23 1996-12-03 Board Of Regents Of The University Of Nebraska Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis
AU2466092A (en) 1992-07-22 1994-02-14 Michael F. Lucey Highly filled polymeric compositions
WO1994026265A1 (en) * 1993-05-06 1994-11-24 Pharmagenesis, Inc. 16-hydroxytriptolide composition and method for immunotherapy
FR2707992B1 (fr) 1993-07-21 1995-10-13 Flamel Tech Sa Nouveaux produits organiques contenant des fonctions thiols réactives, l'un de leurs procédés de préparation et les biomatériaux les contenant.
GB9325415D0 (en) 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
GB9405715D0 (en) 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
FR2733498B1 (fr) * 1995-04-27 1997-05-30 Adir Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
IT1287174B1 (it) 1996-11-15 1998-08-04 Angelini Ricerche Spa Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
US5972998A (en) * 1997-05-23 1999-10-26 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
WO1999019298A1 (en) 1997-10-14 1999-04-22 The Scripps Research Institute iso-CBI AND iso-CI ANALOGS OF CC-1065 AND THE DUOCARMYCINS
NZ504884A (en) 1997-12-08 2002-10-25 Scripps Research Inst Synthesis of the dihydroindole C-ring of CC-1065/duocarmycin analogs and certain intermediates
DE19855859A1 (de) * 1998-12-03 2000-06-08 Degussa Katalysatoren für die enantioselektive Epoxidierung von C=C-Doppelbindungen
FR2787451B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AR023071A1 (es) 1998-12-23 2002-09-04 Syngenta Participations Ag Compuestos de piridincetona, compuestos intermediarios, composicion herbicida e inhibidora del crecimiento de plantas, metodo para controlar la vegetacion indeseada, metodo para inhibir el crecimiento de las plantas, y uso de la composicion para controlar el crecimiento indeseado de plantas.
US6331642B1 (en) 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
WO2002028862A2 (en) * 2000-10-02 2002-04-11 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US20040204394A1 (en) * 2003-04-11 2004-10-14 Aderis Pharmaceuticals, Inc. Triptolide analogues

Similar Documents

Publication Publication Date Title
US8193249B2 (en) Triptolide analogs for the treatment of autoimmune and inflammatory disorders
JP2004525082A5 (https=)
US6608101B1 (en) 1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
US7078431B2 (en) 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
AU2001296542A1 (en) Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US9447025B2 (en) Bicyclic analgesic compounds
US9457004B2 (en) Opsin-binding ligands, compositions and methods of use
US7271274B2 (en) Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20040204394A1 (en) Triptolide analogues
EP4613736A1 (en) Gamma-aminobutyric acid derivative comprising polycyclic structure, method for preparing same, and use thereof
CA2036920A1 (fr) Sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2768307B1 (en) Opsin-binding ligands, compositions and methods of use
AU2007237317A1 (en) Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US20100324133A1 (en) Branched Diepoxide Compounds for the Treatment of Inflammatory Disorders
KR100618006B1 (ko) 나프티리딘 유도체
AU595397B2 (en) 4-hydroxy-4-(substituted thioalkenyl)-cyclohexane- carboxylic acids and derivatives thereof
HK40128965A (en) Gamma-aminobutyric acid derivative comprising polycyclic structure, method for preparing same, and use thereof
Krishna Synthetic studies toward CMI-977, scyphoststin,(R)-(-)-phenylephrine and herbicidin
Reddy Synthetic studies towards the CMI-977, calditol and calanolide