|
US4237224A
(en)
|
1974-11-04 |
1980-12-02 |
Board Of Trustees Of The Leland Stanford Jr. University |
Process for producing biologically functional molecular chimeras
|
|
US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
|
US4489710A
(en)
|
1981-06-23 |
1984-12-25 |
Xoma Corporation |
Composition and method for transplantation therapy
|
|
US4429008B1
(en)
|
1981-12-10 |
1995-05-16 |
Univ California |
Thiol reactive liposomes
|
|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
|
US4603112A
(en)
|
1981-12-24 |
1986-07-29 |
Health Research, Incorporated |
Modified vaccinia virus
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US4866034A
(en)
|
1982-05-26 |
1989-09-12 |
Ribi Immunochem Research Inc. |
Refined detoxified endotoxin
|
|
US4436727A
(en)
|
1982-05-26 |
1984-03-13 |
Ribi Immunochem Research, Inc. |
Refined detoxified endotoxin product
|
|
JPS59116229A
(ja)
|
1982-12-24 |
1984-07-05 |
Teijin Ltd |
細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
|
|
US4673562A
(en)
|
1983-08-19 |
1987-06-16 |
The Children's Medical Center Corporation |
Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
|
|
US4873088A
(en)
|
1983-09-06 |
1989-10-10 |
Liposome Technology, Inc. |
Liposome drug delivery method and composition
|
|
US4625014A
(en)
|
1984-07-10 |
1986-11-25 |
Dana-Farber Cancer Institute, Inc. |
Cell-delivery agent
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4708930A
(en)
|
1984-11-09 |
1987-11-24 |
Coulter Corporation |
Monoclonal antibody to a human carcinoma tumor associated antigen
|
|
US4883750A
(en)
|
1984-12-13 |
1989-11-28 |
Applied Biosystems, Inc. |
Detection of specific sequences in nucleic acids
|
|
US4918164A
(en)
|
1987-09-10 |
1990-04-17 |
Oncogen |
Tumor immunotherapy using anti-idiotypic antibodies
|
|
US6200764B1
(en)
*
|
1985-01-29 |
2001-03-13 |
Bayer Corporation |
Detection, quantitation and classification of ras proteins in body fluids and tissues
|
|
US4638045A
(en)
|
1985-02-19 |
1987-01-20 |
Massachusetts Institute Of Technology |
Non-peptide polyamino acid bioerodible polymers
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
GB8508845D0
(en)
|
1985-04-04 |
1985-05-09 |
Hoffmann La Roche |
Vaccinia dna
|
|
US4777127A
(en)
|
1985-09-30 |
1988-10-11 |
Labsystems Oy |
Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
US5453566A
(en)
|
1986-03-28 |
1995-09-26 |
Calgene, Inc. |
Antisense regulation of gene expression in plant/cells
|
|
US4877611A
(en)
|
1986-04-15 |
1989-10-31 |
Ribi Immunochem Research Inc. |
Vaccine containing tumor antigens and adjuvants
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US6024983A
(en)
|
1986-10-24 |
2000-02-15 |
Southern Research Institute |
Composition for delivering bioactive agents for immune response and its preparation
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
GB8702816D0
(en)
|
1987-02-07 |
1987-03-11 |
Al Sumidaie A M K |
Obtaining retrovirus-containing fraction
|
|
US5219740A
(en)
|
1987-02-13 |
1993-06-15 |
Fred Hutchinson Cancer Research Center |
Retroviral gene transfer into diploid fibroblasts for gene therapy
|
|
AU622104B2
(en)
|
1987-03-11 |
1992-04-02 |
Sangtec Molecular Diagnostics Ab |
Method of assaying of nucleic acids, a reagent combination and kit therefore
|
|
US4735792A
(en)
|
1987-04-28 |
1988-04-05 |
The United States Of America As Represented By The United States Department Of Energy |
Radioiodinated maleimides and use as agents for radiolabeling antibodies
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
IL86724A
(en)
|
1987-06-19 |
1995-01-24 |
Siska Diagnostics Inc |
Methods and kits for amplification and testing of nucleic acid sequences
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
DE10399032I1
(de)
|
1987-08-28 |
2004-01-29 |
Health Research Inc |
Rekombinante Viren.
|
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
WO1989006280A1
(en)
|
1988-01-04 |
1989-07-13 |
E.I. Du Pont De Nemours And Company |
Multiple stage affinity process for isolation of specific cells from a cell mixture
|
|
EP0359789B1
(en)
|
1988-01-21 |
1993-08-04 |
Genentech, Inc. |
Amplification and detection of nucleic acid sequences
|
|
CA1340807C
(en)
|
1988-02-24 |
1999-11-02 |
Lawrence T. Malek |
Nucleic acid amplification process
|
|
US5215926A
(en)
|
1988-06-03 |
1993-06-01 |
Cellpro, Inc. |
Procedure for designing efficient affinity cell separation processes
|
|
AP129A
(en)
|
1988-06-03 |
1991-04-17 |
Smithkline Biologicals S A |
Expression of retrovirus gag protein eukaryotic cells
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
CA1340323C
(en)
|
1988-09-20 |
1999-01-19 |
Arnold E. Hampel |
Rna catalyst for cleaving specific rna sequences
|
|
GB8822492D0
(en)
|
1988-09-24 |
1988-10-26 |
Considine J |
Apparatus for removing tumours from hollow organs of body
|
|
US5549910A
(en)
|
1989-03-31 |
1996-08-27 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
WO1990013361A1
(en)
|
1989-05-04 |
1990-11-15 |
Southern Research Institute |
Improved encapsulation process and products therefrom
|
|
US5725871A
(en)
|
1989-08-18 |
1998-03-10 |
Danbiosyst Uk Limited |
Drug delivery compositions comprising lysophosphoglycerolipid
|
|
EP1001032A3
(en)
|
1989-08-18 |
2005-02-23 |
Chiron Corporation |
Recombinant retroviruses delivering vector constructs to target cells
|
|
KR920007887B1
(ko)
|
1989-08-29 |
1992-09-18 |
스즈키 지도오샤 고오교오 가부시키가이샤 |
내연기관의 배기가스 정화장치
|
|
CA2039718C
(en)
|
1989-08-31 |
2003-02-25 |
John J. Rossi |
Chimeric dna-rna catalytic sequences
|
|
US5707644A
(en)
|
1989-11-04 |
1998-01-13 |
Danbiosyst Uk Limited |
Small particle compositions for intranasal drug delivery
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
EP0500799B1
(en)
|
1989-11-16 |
1998-01-14 |
Duke University |
Particle mediated transformation of animal skin tissue cells
|
|
FR2658432B1
(fr)
|
1990-02-22 |
1994-07-01 |
Medgenix Group Sa |
Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation.
|
|
US5466468A
(en)
|
1990-04-03 |
1995-11-14 |
Ciba-Geigy Corporation |
Parenterally administrable liposome formulation comprising synthetic lipids
|
|
WO1991016116A1
(en)
|
1990-04-23 |
1991-10-31 |
Cellpro Incorporated |
Immunoselection device and method
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
AU8200191A
(en)
|
1990-07-09 |
1992-02-04 |
United States of America, as represented by the Secretary, U.S. Department of Commerce, The |
High efficiency packaging of mutant adeno-associated virus using amber suppressions
|
|
JP3218637B2
(ja)
|
1990-07-26 |
2001-10-15 |
大正製薬株式会社 |
安定なリポソーム水懸濁液
|
|
US5789573A
(en)
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
|
MY109299A
(en)
|
1990-08-15 |
1996-12-31 |
Virogenetics Corp |
Recombinant pox virus encoding flaviviral structural proteins
|
|
JP2958076B2
(ja)
|
1990-08-27 |
1999-10-06 |
株式会社ビタミン研究所 |
遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
|
|
AU649074B2
(en)
|
1990-10-12 |
1994-05-12 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Modified ribozymes
|
|
DK0553288T3
(da)
|
1990-10-18 |
1997-12-29 |
Cellpro Inc |
Apparat og fremgangsmåde til udskillelse af partikler ved brug af en eftergivende beholder
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
JP3015969B2
(ja)
*
|
1990-11-30 |
2000-03-06 |
ダイナボット株式会社 |
扁平上皮癌関連抗原蛋白質及び該蛋白質をコードするｄｎａ
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5399363A
(en)
|
1991-01-25 |
1995-03-21 |
Eastman Kodak Company |
Surface modified anticancer nanoparticles
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
ATE237694T1
(de)
|
1991-08-20 |
2003-05-15 |
Us Gov Health & Human Serv |
Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
|
|
US5240856A
(en)
|
1991-10-23 |
1993-08-31 |
Cellpro Incorporated |
Apparatus for cell separation
|
|
US5756353A
(en)
|
1991-12-17 |
1998-05-26 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol-and liposome-based delivery
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
CA2135646A1
(en)
|
1992-05-11 |
1993-11-25 |
Kenneth G. Draper |
Method and reagent for inhibiting viral replication
|
|
ATE155681T1
(de)
|
1992-05-18 |
1997-08-15 |
Minnesota Mining & Mfg |
Einrichtung zur transmucosalen wirkstoffabgabe
|
|
US5792451A
(en)
|
1994-03-02 |
1998-08-11 |
Emisphere Technologies, Inc. |
Oral drug delivery compositions and methods
|
|
DE69313134T2
(de)
|
1992-06-25 |
1998-02-26 |
Smithkline Beecham Biolog |
Adjuvantien enthaltende impfstoffzusammensetzung
|
|
JPH07509133A
(ja)
|
1992-07-17 |
1995-10-12 |
リボザイム・ファーマシューティカルズ・インコーポレイテッド |
動物疾患の処置のための方法および剤
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5359681A
(en)
|
1993-01-11 |
1994-10-25 |
University Of Washington |
Fiber optic sensor and methods and apparatus relating thereto
|
|
DE69418699T2
(de)
|
1993-01-11 |
1999-09-30 |
Dana-Farber Cancer Institute, Boston |
Induktion der antworten zytotoxischer t-lymphozyten
|
|
US5633234A
(en)
|
1993-01-22 |
1997-05-27 |
The Johns Hopkins University |
Lysosomal targeting of immunogens
|
|
IL108367A0
(en)
|
1993-01-27 |
1994-04-12 |
Hektoen Inst For Medical Resea |
Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
|
|
US5654186A
(en)
|
1993-02-26 |
1997-08-05 |
The Picower Institute For Medical Research |
Blood-borne mesenchymal cells
|
|
FR2702160B1
(fr)
|
1993-03-02 |
1995-06-02 |
Biovecteurs As |
Vecteurs particulaires synthétiques et procédé de préparation.
|
|
FR2704145B1
(fr)
|
1993-04-21 |
1995-07-21 |
Pasteur Institut |
Vecteur particulaire et composition pharmaceutique le contenant.
|
|
US5543158A
(en)
|
1993-07-23 |
1996-08-06 |
Massachusetts Institute Of Technology |
Biodegradable injectable nanoparticles
|
|
US5705159A
(en)
*
|
1993-08-31 |
1998-01-06 |
John Wayne Cancer Institute |
Immunoreactive peptide sequence from a 43 KD human cancer antigen
|
|
US6015686A
(en)
|
1993-09-15 |
2000-01-18 |
Chiron Viagene, Inc. |
Eukaryotic layered vector initiation systems
|
|
US5595721A
(en)
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
WO1995019799A1
(en)
|
1994-01-21 |
1995-07-27 |
Agracetus, Inc. |
Gas driven gene delivery instrument
|
|
US5591317A
(en)
|
1994-02-16 |
1997-01-07 |
Pitts, Jr.; M. Michael |
Electrostatic device for water treatment
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5631359A
(en)
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
|
US5505947A
(en)
|
1994-05-27 |
1996-04-09 |
The University Of North Carolina At Chapel Hill |
Attenuating mutations in Venezuelan Equine Encephalitis virus
|
|
AU713040B2
(en)
|
1994-07-15 |
1999-11-18 |
University Of Iowa Research Foundation, The |
Immunomodulatory oligonucleotides
|
|
US5589579A
(en)
*
|
1994-07-19 |
1996-12-31 |
Cytoclonal Pharmaceutics, Inc. |
Gene sequence and probe for a marker of non-small cell lung carinoma
|
|
FR2723849B1
(fr)
|
1994-08-31 |
1997-04-11 |
Biovector Therapeutics Sa |
Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique
|
|
US5783683A
(en)
|
1995-01-10 |
1998-07-21 |
Genta Inc. |
Antisense oligonucleotides which reduce expression of the FGFRI gene
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
GB9502879D0
(en)
|
1995-02-14 |
1995-04-05 |
Oxford Biosciences Ltd |
Particle delivery
|
|
US5580579A
(en)
|
1995-02-15 |
1996-12-03 |
Nano Systems L.L.C. |
Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
|
|
IE80468B1
(en)
|
1995-04-04 |
1998-07-29 |
Elan Corp Plc |
Controlled release biodegradable nanoparticles containing insulin
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
EP0832282A1
(en)
|
1995-06-02 |
1998-04-01 |
Incyte Pharmaceuticals, Inc. |
IMPROVED METHOD FOR OBTAINING FULL-LENGTH cDNA SEQUENCES
|
|
US5747470A
(en)
|
1995-06-07 |
1998-05-05 |
Gen-Probe Incorporated |
Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
|
|
US5738868A
(en)
|
1995-07-18 |
1998-04-14 |
Lipogenics Ltd. |
Liposome compositions and kits therefor
|
|
EP0871747A1
(en)
|
1996-01-02 |
1998-10-21 |
Chiron Viagene, Inc. |
Immunostimulation mediated by gene-modified dendritic cells
|
|
US5856462A
(en)
|
1996-09-10 |
1999-01-05 |
Hybridon Incorporated |
Oligonucleotides having modified CpG dinucleosides
|
|
US5739119A
(en)
|
1996-11-15 |
1998-04-14 |
Galli; Rachel L. |
Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
|
|
US5811407A
(en)
|
1997-02-19 |
1998-09-22 |
The University Of North Carolina At Chapel Hill |
System for the in vivo delivery and expression of heterologous genes in the bone marrow
|
|
US5993412A
(en)
|
1997-05-19 |
1999-11-30 |
Bioject, Inc. |
Injection apparatus
|
|
GB9727262D0
(en)
|
1997-12-24 |
1998-02-25 |
Smithkline Beecham Biolog |
Vaccine
|
|
JP4480268B2
(ja)
|
1998-02-12 |
2010-06-16 |
イミューン コンプレックス コーポレイション |
戦略的修飾されたｂ型肝炎コアタンパク質及びそれらの誘導体
|
|
BR9909915A
(pt)
|
1998-04-09 |
2000-12-26 |
Smithkline Beecham Biolog |
Composições adjuvantes
|
|
US6297364B1
(en)
*
|
1998-04-17 |
2001-10-02 |
Ludwig Institute For Cancer Research |
Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof
|
|
ATE315405T1
(de)
|
1998-08-10 |
2006-02-15 |
Antigenics Inc |
Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung
|
|
ATE399793T1
(de)
*
|
1999-04-02 |
2008-07-15 |
Corixa Corp |
Verbindungen und verfahren für therapie und diagnose von lungenkrebs
|
|
AU2001264559A1
(en)
*
|
2000-06-05 |
2001-12-17 |
Avalon Pharmaceuticals |
Cancer gene determination and therapeutic screening using signature gene sets
|
|
EP1319069B1
(en)
*
|
2000-06-28 |
2008-05-21 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of lung cancer
|
|
EP1317275A1
(de)
*
|
2000-09-06 |
2003-06-11 |
Müller, Friederike |
Arzneimittel mit einer für das rna-bindende koc-protein kodierenden dna-sequenz, einem koc-protein oder einer dna-sequenz des koc-promotors
|