JP2004523217A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004523217A5 JP2004523217A5 JP2002545150A JP2002545150A JP2004523217A5 JP 2004523217 A5 JP2004523217 A5 JP 2004523217A5 JP 2002545150 A JP2002545150 A JP 2002545150A JP 2002545150 A JP2002545150 A JP 2002545150A JP 2004523217 A5 JP2004523217 A5 JP 2004523217A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- undifferentiated
- population
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 description 45
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 230000001665 lethal effect Effects 0.000 description 11
- 210000000130 stem cell Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 108010017842 Telomerase Proteins 0.000 description 4
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 description 4
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 description 4
- 230000006907 apoptotic process Effects 0.000 description 4
- 230000000779 depleting effect Effects 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 4
- 241000288906 Primates Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000006601 Thymidine Kinase Human genes 0.000 description 2
- 108020004440 Thymidine kinase Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
- 229960002963 ganciclovir Drugs 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25344300P | 2000-11-27 | 2000-11-27 | |
| US25335700P | 2000-11-27 | 2000-11-27 | |
| US09/783,203 US6576464B2 (en) | 2000-11-27 | 2001-02-13 | Methods for providing differentiated stem cells |
| PCT/US2001/044309 WO2002042445A2 (en) | 2000-11-27 | 2001-11-26 | Differentiated cells suitable for human therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004523217A JP2004523217A (ja) | 2004-08-05 |
| JP2004523217A5 true JP2004523217A5 (enExample) | 2005-05-26 |
Family
ID=27400669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002545150A Pending JP2004523217A (ja) | 2000-11-27 | 2001-11-26 | ヒトの治療に適した分化細胞 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6576464B2 (enExample) |
| EP (1) | EP1337632B1 (enExample) |
| JP (1) | JP2004523217A (enExample) |
| KR (1) | KR20030081334A (enExample) |
| CN (2) | CN101928692A (enExample) |
| AU (2) | AU3768102A (enExample) |
| CA (1) | CA2434760C (enExample) |
| ES (1) | ES2544942T3 (enExample) |
| GB (1) | GB2386120B (enExample) |
| IL (2) | IL155695A0 (enExample) |
| WO (1) | WO2002042445A2 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| BR0014864A (pt) * | 1999-10-15 | 2002-11-19 | Advanced Cell Tech Inc | Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
| US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
| US20030104426A1 (en) * | 2001-06-18 | 2003-06-05 | Linsley Peter S. | Signature genes in chronic myelogenous leukemia |
| CA2478681A1 (en) * | 2001-10-22 | 2003-05-01 | University Of Rochester | Telomerase interference |
| US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US8404229B2 (en) | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
| EP1463803B1 (en) | 2001-12-07 | 2018-02-14 | Asterias Biotherapeutics, Inc. | Hematopoietic cells from human embryonic stem cells |
| US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
| US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US7595043B2 (en) * | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| US9597395B2 (en) * | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US20050095228A1 (en) * | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US20030161816A1 (en) | 2001-12-07 | 2003-08-28 | Fraser John K. | Systems and methods for treating patients with processed lipoaspirate cells |
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| WO2003066839A1 (en) * | 2002-02-05 | 2003-08-14 | Rappaport Family Institute For Research In The Medical Sciences | Lineage committed stem cells selected for telomerase promoter activity |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| AU2003231950A1 (en) * | 2002-05-30 | 2003-12-19 | Celgene Corporation | Modulating cell differentiation and treating myeloproliferative disorders with JNK/MKK inhibitors |
| US7285415B2 (en) | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US20050265983A1 (en) * | 2002-11-17 | 2005-12-01 | Eldad Melamed | Methods, nucleic acid constructs and cells for treating neurodegenerative disorders |
| US20050014116A1 (en) * | 2002-11-27 | 2005-01-20 | Reid Gregory S. | Testing information comprehension of contact center users |
| US20040214324A1 (en) * | 2002-12-09 | 2004-10-28 | Ole Isacson | Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases |
| EP2457999B1 (en) | 2002-12-16 | 2018-10-17 | Technion Research & Development Foundation Ltd. | Culture medium for pluripotent stem cells |
| US20060211111A1 (en) * | 2002-12-18 | 2006-09-21 | Maisam Mitalipova | Compositions and methods for neural cell production and stabilization |
| US7153650B2 (en) | 2003-03-13 | 2006-12-26 | Geron Corporation | Marker system for preparing and characterizing high-quality human embryonic stem cells |
| WO2004104184A1 (ja) * | 2003-05-20 | 2004-12-02 | Riken | 内胚葉系幹細胞の調製 |
| WO2004113515A2 (en) | 2003-06-20 | 2004-12-29 | Axiogenesis Ag | Tissue modeling in embryonic stem (es) cell system |
| AR046076A1 (es) * | 2003-07-18 | 2005-11-23 | Otsuka Pharma Co Ltd | Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida |
| US20050054100A1 (en) * | 2003-09-08 | 2005-03-10 | Rennard Stephen I. | Methods for fibroblast differentiation |
| JP2007512838A (ja) | 2003-12-01 | 2007-05-24 | インヴィトロジェン コーポレーション | 組換え部位を含む核酸分子およびその使用方法 |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| SG188122A1 (en) * | 2004-01-23 | 2013-03-28 | Advanced Cell Tech Inc | Improved modalities for the treatment of degenerative diseases of the retina |
| WO2005079849A2 (en) * | 2004-02-25 | 2005-09-01 | Zgene A/S | Compounds for enhanced cancer therapy |
| US20050277124A1 (en) | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
| WO2006014159A2 (en) * | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| EP1812556A4 (en) * | 2004-10-05 | 2011-02-02 | Univ Georgia | NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| WO2006126972A1 (en) * | 2005-05-27 | 2006-11-30 | Agency For Science, Technology And Research | Method of delivering nucleic acid molecules into embryonic stem cells using baculoviral vectors |
| ES2524996T3 (es) | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC |
| AU2006262369B2 (en) | 2005-06-22 | 2012-07-05 | Asterias Biotherapeutics, Inc. | Suspension culture of human embryonic stem cells |
| EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| CN1966080B (zh) * | 2005-11-17 | 2011-06-08 | 李凌松 | 一种治疗老年痴呆症、帕金森病的神经干细胞注射液 |
| WO2007066338A1 (en) * | 2005-12-08 | 2007-06-14 | Ramot At Tel Aviv University Ltd. | Isolated oligodendrocyte-like cells and populations comprising same for the treatment of cns diseases |
| WO2007139551A1 (en) * | 2006-05-30 | 2007-12-06 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells from adipose tissue |
| WO2008013863A2 (en) * | 2006-07-26 | 2008-01-31 | Cytori Therapeutics, Inc. | Generation of adipose tissue and adipocytes |
| DK3441459T3 (da) | 2006-08-02 | 2021-06-07 | Technion Res & Dev Foundation | Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur |
| US20080081370A1 (en) * | 2006-09-28 | 2008-04-03 | Peiman Hematti | Directed differentiation of human embryonic stem cells into mesenchymal/stromal cells |
| ES2764473T3 (es) | 2007-10-12 | 2020-06-03 | Astellas Inst For Regenerative Medicine | Métodos mejorados para producir células RPE y composiciones de células RPE |
| US8501474B2 (en) * | 2007-10-15 | 2013-08-06 | Technion Research & Development Foundation Limited | Methods of generating embryoid bodies and uses of same |
| DK2285951T3 (en) | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| WO2010114136A1 (ja) * | 2009-03-30 | 2010-10-07 | 第一三共株式会社 | 多能性幹細胞及び心筋細胞以外の分化細胞に対する細胞死誘導方法 |
| CA2760574C (en) * | 2009-05-01 | 2020-10-27 | Cytori Therapeutics, Inc. | Device and method for preparing tissue for an adipose graft |
| WO2010151782A1 (en) * | 2009-06-25 | 2010-12-29 | Geron Corporation | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
| EP2499236B1 (en) | 2009-11-12 | 2020-01-01 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| CN102933704A (zh) | 2010-04-08 | 2013-02-13 | 爱丁堡大学管理处 | 软骨祖细胞、用于细胞衍生的方案和其用途 |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| JP6037393B2 (ja) * | 2011-03-29 | 2016-12-07 | 国立大学法人 鹿児島大学 | 幹細胞における腫瘍化原因細胞の除去方法 |
| US10745468B2 (en) | 2011-12-22 | 2020-08-18 | Kota Biotherapeutics, Llc | Compositions and methods for modified B cells expressing reassigned biological agents |
| US9175072B2 (en) | 2011-12-22 | 2015-11-03 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen |
| US8962315B2 (en) | 2011-12-22 | 2015-02-24 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen |
| US10233424B2 (en) | 2011-12-22 | 2019-03-19 | Elwha Llc | Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin |
| WO2013134015A2 (en) | 2012-03-05 | 2013-09-12 | Wake Forest University Health Sciences | Non-viral episomal suicide construct |
| KR102423106B1 (ko) | 2013-06-11 | 2022-07-21 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| CN109563482A (zh) | 2016-06-10 | 2019-04-02 | 埃尔瓦有限公司 | 含表达异于分泌免疫球蛋白和细胞溶解功能的膜免疫球蛋白的b淋巴细胞系的组合物和方法 |
| KR102106895B1 (ko) * | 2017-02-16 | 2020-05-07 | 고려대학교 산학협력단 | 골재생 효능이 우수한 골질환 예방 또는 치료용 조성물 |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| EP3692139B1 (en) | 2017-10-03 | 2024-11-06 | SDF BioPharma Inc. | Treating diabetes with genetically modified beta cells |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN119709646A (zh) * | 2024-09-14 | 2025-03-28 | 青岛阿尔泰基因工程有限公司 | 一种治疗颅咽管瘤的慢病毒及其制备方法和应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959313A (en) | 1987-06-22 | 1990-09-25 | The Jackson Laboratory | Cellular enhancer for expressing genes in undifferentiated stem cells |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5639613A (en) | 1992-05-13 | 1997-06-17 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
| AU678988B2 (en) | 1992-07-27 | 1997-06-19 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
| US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
| US5489304A (en) | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
| US5639618A (en) | 1994-05-13 | 1997-06-17 | Plurion, Inc. | Method of isolating a lineage specific stem cell in vitro |
| GB9417831D0 (en) | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| GB9505663D0 (en) | 1995-03-21 | 1995-05-10 | Stringer Bradley M J | Genetically modified neural cells |
| US6117985A (en) | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
| GB9526509D0 (en) | 1995-12-23 | 1996-02-28 | Univ Dundee | Gene control |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| WO1997032025A1 (en) | 1996-03-01 | 1997-09-04 | Regents Of The University Of Minnesota | Method for selective engraftment of drug-resistant hematopoietic stem cells |
| EP0929328A4 (en) | 1996-08-26 | 2000-08-02 | Hemasure Inc | PROCESS FOR REMOVING TUMOR CELLS FROM PRODUCTS CONTAINING STEM CELLS CONTAMINATED BY TUMOR CELLS |
| FI990655A7 (fi) | 1996-10-01 | 1999-06-01 | Geron Corp | Ihmistelomeraasin katalyyttinen alayksikkö |
| GB9621383D0 (en) | 1996-10-14 | 1996-12-04 | Roslin Inst Edinburgh | Transgene expression |
| EP0991321A4 (en) | 1997-02-05 | 2002-01-30 | Gen Hospital Corp | TOLERANCE TO ANTIGENT NATURAL ANTIBODIES |
| AU6346898A (en) | 1997-03-06 | 1998-09-22 | University Of Massachusetts | Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| DE19727962A1 (de) | 1997-07-02 | 1999-01-14 | Juergen Hescheler | Fluoreszierende Proteine als zelltypspezifische Reporter |
| AU9200298A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6482937B1 (en) | 1997-10-09 | 2002-11-19 | Biotransplant, Inc. | Porcine Oct-4 promoter |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
| DE19757984A1 (de) | 1997-12-24 | 1999-07-01 | Bayer Ag | Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung |
| WO1999045100A1 (en) | 1998-03-02 | 1999-09-10 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Embryonic or stem-like cell lines produced by cross-species nuclear transplantation |
| GB9811859D0 (en) | 1998-06-02 | 1998-07-29 | Biotech & Biolog Scien Res | Biological manipulation |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| BR9914465A (pt) | 1998-09-29 | 2001-10-09 | Gamida Cell Ltd | Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células |
| US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6087168A (en) | 1999-01-20 | 2000-07-11 | Cedars Sinai Medical Center | Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells |
| ES2220448T3 (es) | 1999-02-04 | 2004-12-16 | Geron Corporation | Secuencias reguladoras de la transcripcion de la telomerasa transcriptasa inversa. |
| DK1226233T3 (da) | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US6921665B2 (en) | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
| CA2430653A1 (en) | 2000-11-27 | 2002-08-08 | Yissum Research Development Company Of The Hebrew University In Jerusalem | Transfection of human embryonic stem cells |
| US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
-
2001
- 2001-02-13 US US09/783,203 patent/US6576464B2/en not_active Expired - Lifetime
- 2001-11-26 WO PCT/US2001/044309 patent/WO2002042445A2/en not_active Ceased
- 2001-11-26 CN CN2009102249802A patent/CN101928692A/zh active Pending
- 2001-11-26 KR KR10-2003-7007100A patent/KR20030081334A/ko not_active Withdrawn
- 2001-11-26 IL IL15569501A patent/IL155695A0/xx active IP Right Grant
- 2001-11-26 EP EP01986488.3A patent/EP1337632B1/en not_active Expired - Lifetime
- 2001-11-26 ES ES01986488.3T patent/ES2544942T3/es not_active Expired - Lifetime
- 2001-11-26 CN CNA018196470A patent/CN1478145A/zh active Pending
- 2001-11-26 CA CA 2434760 patent/CA2434760C/en not_active Expired - Fee Related
- 2001-11-26 GB GB0313389A patent/GB2386120B/en not_active Expired - Fee Related
- 2001-11-26 AU AU3768102A patent/AU3768102A/xx active Pending
- 2001-11-26 AU AU2002237681A patent/AU2002237681B2/en not_active Ceased
- 2001-11-26 JP JP2002545150A patent/JP2004523217A/ja active Pending
-
2002
- 2002-05-07 US US10/141,220 patent/US20030040111A1/en not_active Abandoned
-
2003
- 2003-04-30 IL IL155695A patent/IL155695A/en not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/359,341 patent/US8426198B2/en not_active Expired - Fee Related
-
2013
- 2013-03-15 US US13/837,522 patent/US9023645B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004523217A5 (enExample) | ||
| CA2438501C (en) | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof | |
| JP6272628B2 (ja) | 多能性成体幹細胞およびそれを単離する方法 | |
| US7015037B1 (en) | Multiponent adult stem cells and methods for isolation | |
| Hirano et al. | Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells | |
| JP2011525798A (ja) | 歯髄類似細胞（ｄｐｍｓｃ）ならびにその単離および使用の方法 | |
| JP2017148079A5 (enExample) | ||
| Nishikawa | A complex linkage in the developmental pathway of endothelial and hematopoietic cells | |
| JP2022191462A (ja) | 神経幹細胞組成物および神経変性障害を処置するための方法 | |
| Schmandt et al. | High-purity lineage selection of embryonic stem cell-derived neurons | |
| Hara et al. | Embryonic stem cells are capable of generating a neuronal network in the adult mouse retina | |
| JP2009017891A (ja) | 多能性成体幹細胞、その起源、それを得る方法および維持する方法、それを分化させる方法、その使用法、ならびにそれ由来の細胞 | |
| Lengerke et al. | Disease Models from Pluripotent Stem Cells: Turning Back Time in Disease Pathogenesis? | |
| Greenberg et al. | Pluripotent Adult Stem Cells: A Potential Revolution in Regenerative Medicine and Tissue Engineering | |
| US20060008451A1 (en) | In vivo methods for effecting tissue specific differentiation of embryonic stem cells | |
| Mukhopadhyay | Perspective on liver regeneration by bone marrow–derived stem cells—A scientific realization or a paradox | |
| WO2021190226A1 (zh) | 单碱基编辑介导的剪接修复在制备治疗脊髓性肌萎缩症中的应用 | |
| Tada | Nuclear reprogramming: an overview | |
| Seo et al. | Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency | |
| WO2013144409A2 (es) | Vectores para la identificación del linaje hematopoyético | |
| Hu et al. | A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control | |
| Zaki et al. | Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size | |
| Samokhvalov et al. | Hematopoietic Development of Human Pluripotent Stem Cells | |
| ES2368809T3 (es) | Células madre adultas multipotentes y procedimientos para su aislamiento. | |
| D'Amour | Sox2 defines distinct functional classes of stem cells |