JP2004521897A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004521897A5 JP2004521897A5 JP2002562325A JP2002562325A JP2004521897A5 JP 2004521897 A5 JP2004521897 A5 JP 2004521897A5 JP 2002562325 A JP2002562325 A JP 2002562325A JP 2002562325 A JP2002562325 A JP 2002562325A JP 2004521897 A5 JP2004521897 A5 JP 2004521897A5
- Authority
- JP
- Japan
- Prior art keywords
- itraconazole
- particles
- dosage form
- particle
- strong acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 24
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 17
- 229960004130 itraconazole Drugs 0.000 claims 17
- 238000000034 method Methods 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 8
- 239000011162 core material Substances 0.000 claims 8
- 239000002552 dosage form Substances 0.000 claims 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 6
- 229920003169 water-soluble polymer Polymers 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 4
- 239000006186 oral dosage form Substances 0.000 claims 4
- 201000002909 Aspergillosis Diseases 0.000 claims 3
- 208000036641 Aspergillus infections Diseases 0.000 claims 3
- 201000002563 Histoplasmosis Diseases 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 208000010195 Onychomycosis Diseases 0.000 claims 3
- 201000005882 tinea unguium Diseases 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 239000000049 pigment Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 150000003460 sulfonic acids Chemical class 0.000 claims 2
- 239000004408 titanium dioxide Substances 0.000 claims 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26665301P | 2001-02-06 | 2001-02-06 | |
| US09/933,032 US6663897B2 (en) | 2001-02-06 | 2001-08-20 | Oral itraconazole formulations and methods of making the same |
| PCT/NL2002/000080 WO2002062318A2 (en) | 2001-02-06 | 2002-02-01 | Oral itraconazole formulations and methods of making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521897A JP2004521897A (ja) | 2004-07-22 |
| JP2004521897A5 true JP2004521897A5 (https=) | 2005-12-22 |
Family
ID=26951964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562325A Pending JP2004521897A (ja) | 2001-02-06 | 2002-02-01 | 経口イトラコナゾール調製物およびその製造法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6663897B2 (https=) |
| EP (1) | EP1357899B1 (https=) |
| JP (1) | JP2004521897A (https=) |
| AT (1) | ATE369840T1 (https=) |
| AU (1) | AU2002233822A1 (https=) |
| CA (1) | CA2437372A1 (https=) |
| DE (1) | DE60221795T2 (https=) |
| MX (1) | MXPA03006980A (https=) |
| WO (1) | WO2002062318A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015239D0 (en) * | 2000-06-21 | 2000-08-16 | Biochemie Gmbh | Organic compounds |
| US8071133B2 (en) | 2001-08-20 | 2011-12-06 | Stiefel Laboratories, Inc. | Oral dosage forms of water insoluble drugs and methods of making the same |
| US20040115266A1 (en) * | 2002-02-01 | 2004-06-17 | Namburi Ranga Raju | Oral itraconazole formulations and methods of making the same |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7446107B2 (en) | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
| WO2004000284A1 (en) | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| CA2477923C (en) | 2002-03-01 | 2021-02-23 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
| EP1511490A4 (en) | 2002-05-31 | 2009-03-11 | Transform Pharmaceuticals Inc | NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| EP1539111A1 (en) * | 2002-08-05 | 2005-06-15 | DSM IP Assets B.V. | Oral dosage forms of water insoluble drugs and methods of making the same |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| US20050074494A1 (en) * | 2003-10-06 | 2005-04-07 | Xiu-Xiu Cheng | Itraconazole immediate release formulation |
| US20050118265A1 (en) * | 2003-11-28 | 2005-06-02 | Anandi Krishnan | Antifungal oral dosage forms and the methods for preparation |
| GB0612695D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Gent | Process for preparing a solid dosage form |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791111A (en) | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| IT1263831B (it) | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| CA2258683C (en) * | 1996-06-28 | 2007-07-31 | Schering Corporation | Oral composition comprising a triazole antifungal compound |
| FR2758461A1 (fr) | 1997-01-17 | 1998-07-24 | Pharma Pass | Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation |
| JP3608800B2 (ja) * | 1997-03-26 | 2005-01-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗真菌剤およびポリマーでコートされたコアを有するペレット剤 |
| BR9906712A (pt) * | 1998-07-17 | 2000-10-10 | Janssen Pharmaceutica Nv | Péletes que apresentam um núcleo revestido com um antifúngico e um polìmero |
| SK288117B6 (sk) | 1998-11-20 | 2013-09-03 | Skyepharma Canada Inc. | Rapidly dispersing solid dry therapeutic dosage form |
| ES2251985T3 (es) | 1999-03-24 | 2006-05-16 | R.P. Scherer Technologies, Inc. | Particula granulada para mejorar la solubilidad acuosa de farmacos, y su procedimiento de preparacion. |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| KR100331529B1 (ko) | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
-
2001
- 2001-08-20 US US09/933,032 patent/US6663897B2/en not_active Expired - Lifetime
-
2002
- 2002-02-01 EP EP02700887A patent/EP1357899B1/en not_active Expired - Lifetime
- 2002-02-01 DE DE60221795T patent/DE60221795T2/de not_active Expired - Fee Related
- 2002-02-01 JP JP2002562325A patent/JP2004521897A/ja active Pending
- 2002-02-01 AT AT02700887T patent/ATE369840T1/de not_active IP Right Cessation
- 2002-02-01 CA CA002437372A patent/CA2437372A1/en not_active Abandoned
- 2002-02-01 MX MXPA03006980A patent/MXPA03006980A/es active IP Right Grant
- 2002-02-01 AU AU2002233822A patent/AU2002233822A1/en not_active Abandoned
- 2002-02-01 WO PCT/NL2002/000080 patent/WO2002062318A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004521897A5 (https=) | ||
| IT9020054A1 (https=) | ||
| EP1778201B1 (en) | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof | |
| US5580578A (en) | Controlled release formulations coated with aqueous dispersions of acrylic polymers | |
| CA2038245C (en) | Pharmaceutically useful micropellets | |
| US7070806B2 (en) | Controlled release formulations coated with aqueous dispersions of acrylic polymers | |
| JP2007517050A5 (https=) | ||
| JP2012107048A (ja) | 時限拍動性薬物送達システム | |
| JP2012153724A5 (https=) | ||
| JP2009537611A5 (ja) | リポ酸のペレット | |
| NO170912B (no) | Fremgangsmaate for fremstilling av en fast, holdbar administreringsform | |
| JP2010540548A (ja) | アリスキレンとバルサルタンの医薬組み合わせ剤 | |
| HRP20231012T1 (hr) | Novi sastav s odgođenim oslobađenjem za peroralno davanje | |
| JP2011502140A5 (https=) | ||
| JP2005306778A (ja) | 徐放性製剤及びその製造方法 | |
| JP2004517064A (ja) | 活性成分をベースとする微小顆粒およびその製造方法 | |
| TW407058B (en) | Oral cisapride dosage forms with an extended duration | |
| WO2007102714A1 (en) | Safe controlled release preparation composition containing zolpidem or its salt | |
| CN102727460B (zh) | 一种含有非洛地平和美托洛尔盐的缓释片及其制备方法 | |
| MXPA04009582A (es) | Combinaciones de epinastina, belladona y pseudoefedrina como nuevas formulaciones farmaceuticas. | |
| Bando et al. | Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit® S100: L100 dispersion | |
| AU2003245763B2 (en) | Oral dosage form for controlled drug release | |
| CN105434398B (zh) | 一种雷贝拉唑肠溶微丸及其制备方法 | |
| CA2433915C (en) | Improved controlled release oral dosage form | |
| WO2005107716A1 (en) | Controlled release paroxetine-containing tablets based on a core and a coating |