JP2004519451A5 - - Google Patents
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- Publication number
- JP2004519451A5 JP2004519451A5 JP2002554088A JP2002554088A JP2004519451A5 JP 2004519451 A5 JP2004519451 A5 JP 2004519451A5 JP 2002554088 A JP2002554088 A JP 2002554088A JP 2002554088 A JP2002554088 A JP 2002554088A JP 2004519451 A5 JP2004519451 A5 JP 2004519451A5
- Authority
- JP
- Japan
- Prior art keywords
- phimosis
- corticosteroids
- treatment
- pharmaceutical composition
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003246 corticosteroid Substances 0.000 claims 17
- 229960001334 corticosteroids Drugs 0.000 claims 17
- 206010034878 phimosis Diseases 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 230000000699 topical effect Effects 0.000 claims 12
- 229960002537 betamethasone Drugs 0.000 claims 6
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000001974 Hyaluronidases Human genes 0.000 claims 4
- 229940088598 enzyme Drugs 0.000 claims 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
- -1 acetate ester Chemical class 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 230000003054 hormonal effect Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 229940125379 topical corticosteroid Drugs 0.000 claims 3
- 229940070710 valerate Drugs 0.000 claims 3
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 3
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 2
- 108050009363 Hyaluronidases Proteins 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims 2
- 229960001259 diclofenac Drugs 0.000 claims 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 2
- 229960002773 hyaluronidase Drugs 0.000 claims 2
- 229960000890 hydrocortisone Drugs 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 claims 1
- AIGNCQCMONAWOL-UHFFFAOYSA-N 1,3-benzoselenazole Chemical compound C1=CC=C2[se]C=NC2=C1 AIGNCQCMONAWOL-UHFFFAOYSA-N 0.000 claims 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003470 adrenal cortex hormone Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960002842 clobetasol Drugs 0.000 claims 1
- 229960004703 clobetasol propionate Drugs 0.000 claims 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229960003662 desonide Drugs 0.000 claims 1
- WBGKWQHBNHJJPZ-LECWWXJVSA-N desonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O WBGKWQHBNHJJPZ-LECWWXJVSA-N 0.000 claims 1
- 229960002593 desoximetasone Drugs 0.000 claims 1
- VWVSBHGCDBMOOT-IIEHVVJPSA-N desoximetasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@@H]2O VWVSBHGCDBMOOT-IIEHVVJPSA-N 0.000 claims 1
- 229960001419 fenoprofen Drugs 0.000 claims 1
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 1
- 229960000785 fluocinonide Drugs 0.000 claims 1
- 229960002390 flurbiprofen Drugs 0.000 claims 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229960001067 hydrocortisone acetate Drugs 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- 229940013798 meclofenamate Drugs 0.000 claims 1
- 229960001293 methylprednisolone acetate Drugs 0.000 claims 1
- PLBHSZGDDKCEHR-LFYFAGGJSA-N methylprednisolone acetate Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(C)=O)CC[C@H]21 PLBHSZGDDKCEHR-LFYFAGGJSA-N 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 229960002739 oxaprozin Drugs 0.000 claims 1
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 claims 1
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229960002702 piroxicam Drugs 0.000 claims 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims 1
- 229950010765 pivalate Drugs 0.000 claims 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 229960000894 sulindac Drugs 0.000 claims 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 229960001017 tolmetin Drugs 0.000 claims 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 claims 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 1
- 229950008396 ulobetasol propionate Drugs 0.000 claims 1
- BDSYKGHYMJNPAB-LICBFIPMSA-N ulobetasol propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O BDSYKGHYMJNPAB-LICBFIPMSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0006556-0 | 2000-12-28 | ||
| BR0006556-0A BR0006556A (pt) | 2000-12-28 | 2000-12-28 | Composição farmacêutica para uso tópico à base de corticosteróide para tratamento de fimose |
| PCT/BR2001/000154 WO2002053137A2 (en) | 2000-12-28 | 2001-12-13 | Pharmaceutical composition for treatment of phimosis using topical corticosteroid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004519451A JP2004519451A (ja) | 2004-07-02 |
| JP2004519451A5 true JP2004519451A5 (enExample) | 2005-12-22 |
| JP5095907B2 JP5095907B2 (ja) | 2012-12-12 |
Family
ID=36686652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002554088A Expired - Fee Related JP5095907B2 (ja) | 2000-12-28 | 2001-12-13 | 局所コルチコステロイドを用いた包茎の治療のための医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7666858B2 (enExample) |
| EP (1) | EP1365766B1 (enExample) |
| JP (1) | JP5095907B2 (enExample) |
| CN (1) | CN1270719C (enExample) |
| AR (1) | AR032208A1 (enExample) |
| AU (1) | AU2002221365A1 (enExample) |
| BR (1) | BR0006556A (enExample) |
| DE (1) | DE60121047T2 (enExample) |
| ES (1) | ES2267671T3 (enExample) |
| MX (1) | MXPA03005813A (enExample) |
| RU (1) | RU2279893C2 (enExample) |
| WO (1) | WO2002053137A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070134232A1 (en) * | 2005-12-14 | 2007-06-14 | Joel Studin | Topical bite care composition |
| US20070225670A1 (en) * | 2006-03-14 | 2007-09-27 | Connell Thomas J | Diapers for improving male genital health and methods of using the same |
| JP2010519211A (ja) * | 2007-02-15 | 2010-06-03 | アラーガン、インコーポレイテッド | 膀胱もしくは前立腺障害または多汗症を処置するためのボツリヌス毒素および酵素の使用 |
| CN102933233A (zh) * | 2010-06-17 | 2013-02-13 | 日东电工株式会社 | 肾纤维化处理剂 |
| MX348420B (es) | 2010-07-20 | 2017-06-12 | Halozyme Inc | Efectos secundarios adversos asociados con la administracion de agentes anti-hialuronano y metodos para mejorar o prevenir los efectos secundarios. |
| CN102302779A (zh) * | 2011-07-29 | 2012-01-04 | 岳中瑾 | 治疗包茎的乳膏制剂及其应用 |
| RU2569431C2 (ru) * | 2013-07-08 | 2015-11-27 | Александр Васильевич Газаматов | Способ консервативного лечения фимоза |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| CN110314168A (zh) * | 2019-07-27 | 2019-10-11 | 清远市人民医院 | 一种用于治疗小儿包茎的药物组合物及其制备方法 |
| RU2730476C1 (ru) * | 2019-12-24 | 2020-08-24 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный аграрный университет" | Противовоспалительная мазь для животных |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2058780C1 (ru) * | 1992-11-17 | 1996-04-27 | Совместное русско-американское акционерное общество закрытого типа "Неофарм" | Средство, обладающее тонизирующим действием на гладкую мускулатуру вен, мочевого пузыря и предстательной железы |
-
2000
- 2000-12-28 BR BR0006556-0A patent/BR0006556A/pt active Search and Examination
-
2001
- 2001-12-13 JP JP2002554088A patent/JP5095907B2/ja not_active Expired - Fee Related
- 2001-12-13 ES ES01272567T patent/ES2267671T3/es not_active Expired - Lifetime
- 2001-12-13 WO PCT/BR2001/000154 patent/WO2002053137A2/en not_active Ceased
- 2001-12-13 AU AU2002221365A patent/AU2002221365A1/en not_active Abandoned
- 2001-12-13 RU RU2003119439/15A patent/RU2279893C2/ru not_active IP Right Cessation
- 2001-12-13 EP EP01272567A patent/EP1365766B1/en not_active Expired - Lifetime
- 2001-12-13 US US10/465,977 patent/US7666858B2/en not_active Expired - Fee Related
- 2001-12-13 DE DE60121047T patent/DE60121047T2/de not_active Expired - Lifetime
- 2001-12-13 CN CNB01822296XA patent/CN1270719C/zh not_active Expired - Fee Related
- 2001-12-13 MX MXPA03005813A patent/MXPA03005813A/es active IP Right Grant
- 2001-12-27 AR ARP010106081A patent/AR032208A1/es unknown
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