JP2004517843A5 - - Google Patents
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- Publication number
- JP2004517843A5 JP2004517843A5 JP2002549675A JP2002549675A JP2004517843A5 JP 2004517843 A5 JP2004517843 A5 JP 2004517843A5 JP 2002549675 A JP2002549675 A JP 2002549675A JP 2002549675 A JP2002549675 A JP 2002549675A JP 2004517843 A5 JP2004517843 A5 JP 2004517843A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- phenyl
- alkoxy
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- -1 phenyloxy Chemical group 0.000 claims 3
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000013329 compounding Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- YDIQCMNIHAHECP-UHFFFAOYSA-N ethyl 8,9-dimethoxy-3-methyl-2-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate Chemical compound CC=1N2CCC3=CC(OC)=C(OC)C=C3C2=C(C(=O)OCC)C=1C1=CC=CC=C1 YDIQCMNIHAHECP-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25520600P | 2000-12-13 | 2000-12-13 | |
| US31031201P | 2001-08-06 | 2001-08-06 | |
| PCT/EP2001/014187 WO2002048144A1 (en) | 2000-12-13 | 2001-12-04 | Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517843A JP2004517843A (ja) | 2004-06-17 |
| JP2004517843A5 true JP2004517843A5 (OSRAM) | 2005-12-22 |
Family
ID=26944520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002549675A Pending JP2004517843A (ja) | 2000-12-13 | 2001-12-04 | ピロロ［２．１−ａ］ジヒドロイソキノリンおよびホスホジエステラーゼ１０ａ阻害薬としてのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6930114B2 (OSRAM) |
| EP (1) | EP1347973A1 (OSRAM) |
| JP (1) | JP2004517843A (OSRAM) |
| AU (1) | AU2002227985A1 (OSRAM) |
| CA (1) | CA2431326A1 (OSRAM) |
| HN (1) | HN2001000277A (OSRAM) |
| PE (1) | PE20021085A1 (OSRAM) |
| SV (1) | SV2002000761A (OSRAM) |
| UY (1) | UY27067A1 (OSRAM) |
| WO (1) | WO2002048144A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030236276A1 (en) * | 2001-08-06 | 2003-12-25 | Ulrich Niewohner | Pyrrolo[2.1-a]isoquinoline derivatives |
| WO2003014115A1 (en) * | 2001-08-06 | 2003-02-20 | Bayer Aktiengesellschaft | 3-substituted pyrrolo (2.1-a) isoquinoline derivatives |
| AU2002366362A1 (en) * | 2001-12-18 | 2003-06-30 | Bayer Aktiengesellschaft | 2-substituted pyrrolo(2.1-a)isoquinolines against cancer |
| DE10230604A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| US8338420B1 (en) | 2002-12-04 | 2012-12-25 | Mitsubishi Tanabe Pharma Corporation | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor |
| US7135480B2 (en) * | 2002-12-12 | 2006-11-14 | Cytovia, Inc. | Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis |
| MXPA05013822A (es) * | 2003-06-30 | 2006-02-28 | Altana Pharma Ag | Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer. |
| ES2331519T3 (es) * | 2003-06-30 | 2010-01-07 | Nycomed Gmbh | Derivados de pirrolo-dihidroisoquinolina como inhibidores de pde10. |
| DE602006006544D1 (de) * | 2005-01-12 | 2009-06-10 | Nycomed Gmbh | Neue pyrrolodihydroisochinoline als pde10-inhibitoren |
| CA2595075A1 (en) * | 2005-01-12 | 2006-07-20 | Matthias Vennemann | Pyrrolodihydroisoquinolines as antiproliferative agents |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| CA2654394A1 (en) * | 2006-06-26 | 2008-01-03 | Pfizer Products Inc. | Tricyclic heteroaryl compounds as pde10 inhibitors |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2507244B1 (en) | 2009-12-04 | 2014-11-05 | Nerviano Medical Sciences S.r.l. | Tricyclopyrazole derivatives |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| GB202002926D0 (en) * | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE690792A (OSRAM) | 1966-12-07 | 1967-05-16 | ||
| FR7348M (OSRAM) * | 1967-12-07 | 1969-10-13 | ||
| US4719216A (en) | 1983-06-23 | 1988-01-12 | Mcneilab, Inc. | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants |
| DE3401018A1 (de) | 1984-01-13 | 1985-07-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen |
| GB8718980D0 (en) | 1987-08-11 | 1987-09-16 | May & Baker Ltd | Compositions of matter |
| IT1292092B1 (it) | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
| US6673564B2 (en) | 1999-10-18 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Methods for using 22045, a human cyclic nucleotide phosphodiesterase |
-
2001
- 2001-12-04 US US10/451,707 patent/US6930114B2/en not_active Expired - Fee Related
- 2001-12-04 CA CA002431326A patent/CA2431326A1/en not_active Abandoned
- 2001-12-04 AU AU2002227985A patent/AU2002227985A1/en not_active Abandoned
- 2001-12-04 WO PCT/EP2001/014187 patent/WO2002048144A1/en not_active Ceased
- 2001-12-04 JP JP2002549675A patent/JP2004517843A/ja active Pending
- 2001-12-04 EP EP01989571A patent/EP1347973A1/en not_active Withdrawn
- 2001-12-12 HN HN2001000277A patent/HN2001000277A/es unknown
- 2001-12-12 SV SV2001000761A patent/SV2002000761A/es unknown
- 2001-12-12 UY UY27067A patent/UY27067A1/es not_active Application Discontinuation
-
2002
- 2002-04-23 PE PE2002000338A patent/PE20021085A1/es not_active Application Discontinuation
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