JP2004517824A5 - - Google Patents
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- Publication number
- JP2004517824A5 JP2004517824A5 JP2002544060A JP2002544060A JP2004517824A5 JP 2004517824 A5 JP2004517824 A5 JP 2004517824A5 JP 2002544060 A JP2002544060 A JP 2002544060A JP 2002544060 A JP2002544060 A JP 2002544060A JP 2004517824 A5 JP2004517824 A5 JP 2004517824A5
- Authority
- JP
- Japan
- Prior art keywords
- kit according
- repinotan
- concentration
- measuring
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YGYBFMRFXNDIPO-QGZVFWFLSA-N Repinotan Chemical compound O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 YGYBFMRFXNDIPO-QGZVFWFLSA-N 0.000 claims 3
- 229950009693 Repinotan Drugs 0.000 claims 3
- 210000004369 Blood Anatomy 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- IGKYREHZJIHPML-UNTBIKODSA-N 2-[4-[[(2R)-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydron;chloride Chemical compound Cl.O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 IGKYREHZJIHPML-UNTBIKODSA-N 0.000 claims 1
- 210000001124 Body Fluids Anatomy 0.000 claims 1
- 208000001183 Brain Injury Diseases 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (7)
- ａ） レピノタンおよび／またはレピノタンの生理学的に許容される塩を含有する医薬組成物、および
ｂ） 体液中のレピノタンまたはその代謝産物の濃度を測定するための手段、
を含む、神経変性疾患の緊急処置のためのキット。 - 該医薬組成物がレピノタン塩酸塩を含有する請求項１に記載のキット。
- 血液中または血液から得られる画分中の被分析物の濃度を測定するための手段を包含する、請求項１または２に記載のキット。
- 血漿中の被分析物の濃度を測定するための手段を包含する、請求項３に記載のキット。
- 該手段が免疫反応に従って作用する、請求項１から４までのいずれかに記載のキット。
- 該手段を処置する場所にて使用する、請求項１から５までのいずれかに記載のキット。
- 脳卒中または頭蓋脳損傷の緊急処置のための、請求項１から６までのいずれかに記載のキット。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10058119A DE10058119A1 (de) | 2000-11-22 | 2000-11-22 | Pepinotan-Kit |
| PCT/EP2001/012968 WO2002041881A2 (de) | 2000-11-22 | 2001-11-09 | Repinotan-kit |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005128270A Division JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517824A JP2004517824A (ja) | 2004-06-17 |
| JP2004517824A5 true JP2004517824A5 (ja) | 2005-12-22 |
Family
ID=7664358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002544060A Pending JP2004517824A (ja) | 2000-11-22 | 2001-11-09 | レピノタンのキット |
| JP2005128270A Pending JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005128270A Pending JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6605255B2 (ja) |
| EP (1) | EP1339403B1 (ja) |
| JP (2) | JP2004517824A (ja) |
| KR (1) | KR20030096237A (ja) |
| CN (2) | CN1518446A (ja) |
| AR (1) | AR031761A1 (ja) |
| AT (1) | ATE284212T1 (ja) |
| AU (1) | AU2002227912A1 (ja) |
| BG (1) | BG107803A (ja) |
| BR (1) | BR0115518A (ja) |
| CA (1) | CA2429310A1 (ja) |
| CZ (1) | CZ20031401A3 (ja) |
| DE (2) | DE10058119A1 (ja) |
| DO (1) | DOP2001000293A (ja) |
| EC (1) | ECSP034617A (ja) |
| EE (1) | EE200300242A (ja) |
| ES (1) | ES2234922T3 (ja) |
| GT (1) | GT200100236A (ja) |
| HN (1) | HN2001000262A (ja) |
| HR (1) | HRP20030490A2 (ja) |
| HU (1) | HUP0303294A2 (ja) |
| IL (1) | IL155975A0 (ja) |
| MA (1) | MA26059A1 (ja) |
| MX (1) | MXPA03004499A (ja) |
| MY (1) | MY118345A (ja) |
| NO (1) | NO20032212L (ja) |
| NZ (1) | NZ525964A (ja) |
| PE (1) | PE20020533A1 (ja) |
| PL (1) | PL361628A1 (ja) |
| PT (1) | PT1339403E (ja) |
| RU (1) | RU2003118583A (ja) |
| SI (1) | SI1339403T1 (ja) |
| SK (1) | SK5922003A3 (ja) |
| SV (1) | SV2003000744A (ja) |
| UY (1) | UY27027A1 (ja) |
| WO (1) | WO2002041881A2 (ja) |
| ZA (1) | ZA200303888B (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE102004010050A1 (de) * | 2004-03-02 | 2005-09-22 | Bayer Healthcare Ag | Spezifische monoklonale und polyklonale Antikörper für Repinotan und dessen ringoffene Form |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| WO2009019205A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Crystalline form of a dihydropteridione derivative |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| WO2015011236A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DE19522088A1 (de) * | 1995-06-19 | 1997-01-02 | Bayer Ag | Benzisothiazolyl-substituierte Aminomethylchromane |
| DE19543476A1 (de) * | 1995-11-22 | 1997-05-28 | Troponwerke Gmbh & Co Kg | Verwendung von substituierten Aminomethyl-chromanen zur Behandlung von Schädel-Hirn-Trauma |
| DE19751949A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| DE19754573A1 (de) * | 1997-12-09 | 1999-06-10 | Bayer Ag | Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma |
| WO1999046591A2 (en) * | 1998-03-10 | 1999-09-16 | Strategic Diagnostics, Inc. | Integrated assay device and methods of production and use |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DE19936281C2 (de) | 1999-08-02 | 2002-04-04 | Bayer Ag | Verfahren zur Gefriertrocknung |
-
2000
- 2000-11-22 DE DE10058119A patent/DE10058119A1/de not_active Ceased
-
2001
- 2001-11-09 CN CNA018221440A patent/CN1518446A/zh active Pending
- 2001-11-09 MX MXPA03004499A patent/MXPA03004499A/es unknown
- 2001-11-09 CN CNA2005100859302A patent/CN1715279A/zh active Pending
- 2001-11-09 DE DE2001504790 patent/DE50104790D1/de not_active Expired - Fee Related
- 2001-11-09 SI SI200130270T patent/SI1339403T1/xx unknown
- 2001-11-09 BR BR0115518-0A patent/BR0115518A/pt not_active IP Right Cessation
- 2001-11-09 CZ CZ20031401A patent/CZ20031401A3/cs unknown
- 2001-11-09 AT AT01989448T patent/ATE284212T1/de not_active IP Right Cessation
- 2001-11-09 IL IL15597501A patent/IL155975A0/xx unknown
- 2001-11-09 HU HU0303294A patent/HUP0303294A2/hu unknown
- 2001-11-09 KR KR10-2003-7006854A patent/KR20030096237A/ko not_active Application Discontinuation
- 2001-11-09 AU AU2002227912A patent/AU2002227912A1/en not_active Abandoned
- 2001-11-09 EE EEP200300242A patent/EE200300242A/xx unknown
- 2001-11-09 CA CA002429310A patent/CA2429310A1/en not_active Abandoned
- 2001-11-09 EP EP01989448A patent/EP1339403B1/de not_active Expired - Lifetime
- 2001-11-09 RU RU2003118583/15A patent/RU2003118583A/ru not_active Application Discontinuation
- 2001-11-09 WO PCT/EP2001/012968 patent/WO2002041881A2/de not_active Application Discontinuation
- 2001-11-09 PL PL36162801A patent/PL361628A1/xx not_active Application Discontinuation
- 2001-11-09 PT PT01989448T patent/PT1339403E/pt unknown
- 2001-11-09 JP JP2002544060A patent/JP2004517824A/ja active Pending
- 2001-11-09 NZ NZ525964A patent/NZ525964A/en unknown
- 2001-11-09 SK SK592-2003A patent/SK5922003A3/sk unknown
- 2001-11-09 ES ES01989448T patent/ES2234922T3/es not_active Expired - Lifetime
- 2001-11-16 US US09/991,222 patent/US6605255B2/en not_active Expired - Fee Related
- 2001-11-19 UY UY27027A patent/UY27027A1/es not_active Application Discontinuation
- 2001-11-20 AR ARP010105412A patent/AR031761A1/es unknown
- 2001-11-20 MY MYPI20015310A patent/MY118345A/en unknown
- 2001-11-21 DO DO2001000293A patent/DOP2001000293A/es unknown
- 2001-11-21 HN HN2001000262A patent/HN2001000262A/es unknown
- 2001-11-21 SV SV2001000744A patent/SV2003000744A/es unknown
- 2001-11-21 PE PE2001001162A patent/PE20020533A1/es not_active Application Discontinuation
- 2001-11-22 GT GT200100236A patent/GT200100236A/es unknown
-
2003
- 2003-05-12 BG BG107803A patent/BG107803A/bg unknown
- 2003-05-15 NO NO20032212A patent/NO20032212L/no not_active Application Discontinuation
- 2003-05-20 ZA ZA200303888A patent/ZA200303888B/en unknown
- 2003-05-21 EC EC2003004617A patent/ECSP034617A/es unknown
- 2003-05-22 MA MA27170A patent/MA26059A1/fr unknown
- 2003-05-22 US US10/444,820 patent/US20030203953A1/en not_active Abandoned
- 2003-06-17 HR HR20030490A patent/HRP20030490A2/hr not_active Application Discontinuation
-
2005
- 2005-04-26 JP JP2005128270A patent/JP2005232189A/ja active Pending
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