JP2004517824A5 - - Google Patents
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- Publication number
- JP2004517824A5 JP2004517824A5 JP2002544060A JP2002544060A JP2004517824A5 JP 2004517824 A5 JP2004517824 A5 JP 2004517824A5 JP 2002544060 A JP2002544060 A JP 2002544060A JP 2002544060 A JP2002544060 A JP 2002544060A JP 2004517824 A5 JP2004517824 A5 JP 2004517824A5
- Authority
- JP
- Japan
- Prior art keywords
- kit according
- repinotan
- concentration
- measuring
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YGYBFMRFXNDIPO-QGZVFWFLSA-N repinotan Chemical compound O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 YGYBFMRFXNDIPO-QGZVFWFLSA-N 0.000 claims 3
- 229950009693 repinotan Drugs 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- IGKYREHZJIHPML-UNTBIKODSA-N 2-[4-[[(2r)-3,4-dihydro-2h-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydron;chloride Chemical compound Cl.O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 IGKYREHZJIHPML-UNTBIKODSA-N 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10058119A DE10058119A1 (de) | 2000-11-22 | 2000-11-22 | Pepinotan-Kit |
| PCT/EP2001/012968 WO2002041881A2 (de) | 2000-11-22 | 2001-11-09 | Repinotan-kit |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005128270A Division JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004517824A JP2004517824A (ja) | 2004-06-17 |
| JP2004517824A5 true JP2004517824A5 (enExample) | 2005-12-22 |
Family
ID=7664358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002544060A Pending JP2004517824A (ja) | 2000-11-22 | 2001-11-09 | レピノタンのキット |
| JP2005128270A Pending JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005128270A Pending JP2005232189A (ja) | 2000-11-22 | 2005-04-26 | 神経変性疾患の緊急処置のためのレピノタン |
Country Status (37)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE102004010050A1 (de) * | 2004-03-02 | 2005-09-22 | Bayer Healthcare Ag | Spezifische monoklonale und polyklonale Antikörper für Repinotan und dessen ringoffene Form |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US8329695B2 (en) * | 2007-08-03 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| JP2016525532A (ja) | 2013-07-26 | 2016-08-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 骨髄異形成症候群の処置 |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| DE19522088A1 (de) * | 1995-06-19 | 1997-01-02 | Bayer Ag | Benzisothiazolyl-substituierte Aminomethylchromane |
| DE19543476A1 (de) * | 1995-11-22 | 1997-05-28 | Troponwerke Gmbh & Co Kg | Verwendung von substituierten Aminomethyl-chromanen zur Behandlung von Schädel-Hirn-Trauma |
| DE19751949A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| DE19754573A1 (de) * | 1997-12-09 | 1999-06-10 | Bayer Ag | Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma |
| EP1062510A2 (en) * | 1998-03-10 | 2000-12-27 | Strategic Diagnostics Inc. | Integrated assay device and methods of production and use |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DE19936281C2 (de) | 1999-08-02 | 2002-04-04 | Bayer Ag | Verfahren zur Gefriertrocknung |
-
2000
- 2000-11-22 DE DE10058119A patent/DE10058119A1/de not_active Ceased
-
2001
- 2001-11-09 HR HR20030490A patent/HRP20030490A2/hr not_active Application Discontinuation
- 2001-11-09 PT PT01989448T patent/PT1339403E/pt unknown
- 2001-11-09 EP EP01989448A patent/EP1339403B1/de not_active Expired - Lifetime
- 2001-11-09 WO PCT/EP2001/012968 patent/WO2002041881A2/de not_active Ceased
- 2001-11-09 NZ NZ525964A patent/NZ525964A/en unknown
- 2001-11-09 SK SK592-2003A patent/SK5922003A3/sk unknown
- 2001-11-09 KR KR10-2003-7006854A patent/KR20030096237A/ko not_active Withdrawn
- 2001-11-09 CZ CZ20031401A patent/CZ20031401A3/cs unknown
- 2001-11-09 AT AT01989448T patent/ATE284212T1/de not_active IP Right Cessation
- 2001-11-09 BR BR0115518-0A patent/BR0115518A/pt not_active IP Right Cessation
- 2001-11-09 ES ES01989448T patent/ES2234922T3/es not_active Expired - Lifetime
- 2001-11-09 CN CNA018221440A patent/CN1518446A/zh active Pending
- 2001-11-09 HU HU0303294A patent/HUP0303294A2/hu unknown
- 2001-11-09 RU RU2003118583/15A patent/RU2003118583A/ru not_active Application Discontinuation
- 2001-11-09 AU AU2002227912A patent/AU2002227912A1/en not_active Abandoned
- 2001-11-09 EE EEP200300242A patent/EE200300242A/xx unknown
- 2001-11-09 IL IL15597501A patent/IL155975A0/xx unknown
- 2001-11-09 DE DE2001504790 patent/DE50104790D1/de not_active Expired - Fee Related
- 2001-11-09 CN CNA2005100859302A patent/CN1715279A/zh active Pending
- 2001-11-09 CA CA002429310A patent/CA2429310A1/en not_active Abandoned
- 2001-11-09 JP JP2002544060A patent/JP2004517824A/ja active Pending
- 2001-11-09 SI SI200130270T patent/SI1339403T1/xx unknown
- 2001-11-09 MX MXPA03004499A patent/MXPA03004499A/es unknown
- 2001-11-09 PL PL36162801A patent/PL361628A1/xx not_active Application Discontinuation
- 2001-11-16 US US09/991,222 patent/US6605255B2/en not_active Expired - Fee Related
- 2001-11-19 UY UY27027A patent/UY27027A1/es not_active Application Discontinuation
- 2001-11-20 AR ARP010105412A patent/AR031761A1/es unknown
- 2001-11-20 MY MYPI20015310A patent/MY118345A/en unknown
- 2001-11-21 PE PE2001001162A patent/PE20020533A1/es not_active Application Discontinuation
- 2001-11-21 HN HN2001000262A patent/HN2001000262A/es unknown
- 2001-11-21 SV SV2001000744A patent/SV2003000744A/es unknown
- 2001-11-21 DO DO2001000293A patent/DOP2001000293A/es unknown
- 2001-11-22 GT GT200100236A patent/GT200100236A/es unknown
-
2003
- 2003-05-12 BG BG107803A patent/BG107803A/bg unknown
- 2003-05-15 NO NO20032212A patent/NO20032212D0/no not_active Application Discontinuation
- 2003-05-20 ZA ZA200303888A patent/ZA200303888B/en unknown
- 2003-05-21 EC EC2003004617A patent/ECSP034617A/es unknown
- 2003-05-22 US US10/444,820 patent/US20030203953A1/en not_active Abandoned
- 2003-05-22 MA MA27170A patent/MA26059A1/fr unknown
-
2005
- 2005-04-26 JP JP2005128270A patent/JP2005232189A/ja active Pending
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