JP2004517321A5 - - Google Patents
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- Publication number
- JP2004517321A5 JP2004517321A5 JP2002554723A JP2002554723A JP2004517321A5 JP 2004517321 A5 JP2004517321 A5 JP 2004517321A5 JP 2002554723 A JP2002554723 A JP 2002554723A JP 2002554723 A JP2002554723 A JP 2002554723A JP 2004517321 A5 JP2004517321 A5 JP 2004517321A5
- Authority
- JP
- Japan
- Prior art keywords
- donor
- sensor
- phase
- acceptor
- matrix material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 7
- 239000000463 material Substances 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 2
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000002378 acidificating Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
Claims (11)
- 受容体(発色団もしくは発光団)および供与体(発光団)が別個の化学相中に配置され、それにより、供与体を含有する相が該発光団に特徴的な発光に影響を及ぼすサンプル媒体もしくはサンプル媒体の成分に本質的に不浸透性であることを特徴とする、FRET原理に従って機能しかつサンプル媒体中に含有される被検体に応答性の受容体ならびに供与体を表す、光化学センサー。
- 供与体および受容体がそれぞれマトリックス素材中に存在し、それにより、受容体および供与体相のマトリックス素材がそれぞれ混合された形態もしくは薄層(センサー層)の形態で提供されることを特徴とする、請求項1記載のセンサー。
- 被検体に浸透性かつセンサー層と分析されるべき物質との間に配置される光絶縁層が提供されることを特徴とする、請求項2記載のセンサー。
- センサー層が薄い多孔性素材よりなり、その素材の孔が供与体相のマトリックス素材および受容体相のマトリックス素材を含有する(図5)ことを特徴とする、請求項2および3のいずれか記載のセンサー。
- センサー相が薄膜よりなり、前記薄膜が受容体相のマトリックス素材を表す(図6)ことを特徴とする、請求項2および3のいずれか記載のセンサー。
- 供与体相のマトリックス素材が、受容体相のマトリックス素材中に均一に分布された様式で提供されることを特徴とする、請求項5記載のセンサー。
- 供与体相が粒子の形態で提供されることを特徴とする、請求項2ないし6のいずれか記載のセンサー。
- 受容体分子が供与体相の粒子の表面に結合されることを特徴とする、請求項7記載のセンサー。
- 無可塑ポリマーが供与体相の素材として使用されることを特徴とする、先行する請求項のいずれか記載のセンサー。
- 請求項1ないし9のいずれか記載のセンサーの使用を特徴とする、FRET原理に従った最低1種の被検体および/または気体もしくは液体の測定媒体の成分の定性的および/もしくは定量的測定方法。
- それがサンプルのpH値の測定、サンプル中のイオンの濃度および/もしくは活量の測定、または通常条件下で気体である一方で水性媒体中で酸性もしくはアルカリ性反応を表す成分の測定のために実施されることを特徴とする、請求項10記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0216100A AT410601B (de) | 2000-12-29 | 2000-12-29 | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
PCT/EP2001/015186 WO2002054076A2 (de) | 2000-12-29 | 2001-12-21 | Sensor zur lumineszenz-optischen bestimmung eines analyten |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004517321A JP2004517321A (ja) | 2004-06-10 |
JP2004517321A5 true JP2004517321A5 (ja) | 2005-06-30 |
JP3782780B2 JP3782780B2 (ja) | 2006-06-07 |
Family
ID=3690008
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002554697A Expired - Fee Related JP3740466B2 (ja) | 2000-12-29 | 2001-12-21 | 被検体の発光光学的測定のための試薬 |
JP2002554723A Expired - Lifetime JP3782780B2 (ja) | 2000-12-29 | 2001-12-21 | 被検体の発光光学的測定のためのセンサー |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002554697A Expired - Fee Related JP3740466B2 (ja) | 2000-12-29 | 2001-12-21 | 被検体の発光光学的測定のための試薬 |
Country Status (6)
Country | Link |
---|---|
US (2) | US7456023B2 (ja) |
EP (2) | EP1346220B1 (ja) |
JP (2) | JP3740466B2 (ja) |
AT (3) | AT410601B (ja) |
DE (2) | DE50115064D1 (ja) |
WO (2) | WO2002054076A2 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT410601B (de) * | 2000-12-29 | 2003-06-25 | Hoffmann La Roche | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
US7229835B2 (en) * | 2001-10-25 | 2007-06-12 | The University Of Maryland, Baltimore County | Amine detection method and materials |
US8183052B2 (en) * | 2004-08-19 | 2012-05-22 | Blood Cell Storage, Inc. | Methods and apparatus for sterility testing |
US7608460B2 (en) * | 2004-08-19 | 2009-10-27 | Blood Cell Storage, Inc. | Fluorescent pH detector system and related methods |
US8497134B2 (en) | 2004-08-19 | 2013-07-30 | Blood Cell Storage, Inc. | Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices |
DE102006001642B4 (de) | 2006-01-11 | 2008-02-21 | Sartorius Biotech Gmbh | Sauerstoffsensor und Messverfahren |
EP1892270B1 (de) * | 2006-08-07 | 2009-07-22 | Preentec AG | Nanopartikel eines Authentifizierungssystems |
EP1964927A1 (de) * | 2007-02-27 | 2008-09-03 | F. Hoffmann-La Roche AG | Chinone als Mediatoren für photometrische Teste |
JP2011517934A (ja) | 2008-03-03 | 2011-06-23 | カンザス ステイト ユニバーシティ リサーチ ファウンデーション | プロテアーゼアッセイ |
US20090311799A1 (en) * | 2008-06-13 | 2009-12-17 | Sotzing Gregory A | Nucleic Acid Materials for Nonradiative Energy Transfer and Methods of Production and Use |
WO2010135319A1 (en) * | 2009-05-18 | 2010-11-25 | University Of Connecticut | Nucleic acid-based photovoltaic cell |
US9040307B2 (en) | 2011-05-27 | 2015-05-26 | Blood Cell Storage, Inc. | Fluorescent pH detector system and related methods |
US9228949B2 (en) | 2011-09-06 | 2016-01-05 | The Hong Kong University Of Science And Technology | Aggregation-induced emission luminogens for metal ion detection |
WO2013045487A1 (de) | 2011-09-28 | 2013-04-04 | F. Hoffmann-La Roche Ag | Azomediatoren |
US8742370B2 (en) * | 2012-03-21 | 2014-06-03 | Bah Holdings Llc | Gas sensor |
EP2728343A1 (en) * | 2012-11-06 | 2014-05-07 | Technische Universität Graz | Optical probe for quantitatively determining an analyte |
CA3010895A1 (en) | 2016-01-21 | 2017-07-27 | SeLux Diagnostics, Inc. | Methods for rapid antimicrobial susceptibility testing |
US9834808B2 (en) | 2016-01-21 | 2017-12-05 | SeLux Diagnostics, Inc. | Methods for rapid antibiotic susceptibility testing |
CN109804240A (zh) | 2016-10-05 | 2019-05-24 | 豪夫迈·罗氏有限公司 | 用于多分析物诊断测试元件的检测试剂和电极布置以及其使用方法 |
JP7146765B2 (ja) | 2016-12-23 | 2022-10-04 | セルックス・ダイアグノスティクス・インコーポレイテッド | 改善された迅速な抗菌薬感受性試験のための方法 |
DE102017128564A1 (de) * | 2017-12-01 | 2019-06-06 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensorkappe, optischer Sensor und Verfahren zur Herstellung einer Sensormembran |
US20210015410A1 (en) * | 2019-07-17 | 2021-01-21 | Terumo Cardiovascular Systems Corporation | Fluorescent nanomaterial sensors and related methods |
WO2022038269A1 (en) | 2020-08-20 | 2022-02-24 | Danmarks Tekniske Universitet | Methods, assembly and system for high-throughput, parallel monitoring of reaction systems |
Family Cites Families (25)
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US4396579A (en) | 1981-08-06 | 1983-08-02 | Miles Laboratories, Inc. | Luminescence detection device |
US4457977A (en) * | 1981-09-30 | 1984-07-03 | The Dow Chemical Company | Metallized plastic articles |
US4557900A (en) | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
CA1261717A (en) | 1982-12-23 | 1989-09-26 | John R. Bacon | Method and apparatus for oxygen determination |
US4929561A (en) * | 1985-08-08 | 1990-05-29 | Regents Of The University Of California | Absorption-emission optrode and methods of use thereof |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5254477A (en) * | 1986-06-25 | 1993-10-19 | Trustees Of Tufts College | Flourescence intramolecular energy transfer conjugate compositions and detection methods |
US4822746A (en) * | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
US5037615A (en) * | 1987-10-30 | 1991-08-06 | Cordis Corporation | Tethered pair fluorescence energy transfer indicators, chemical sensors, and method of making such sensors |
AT390517B (de) * | 1988-08-04 | 1990-05-25 | Avl Verbrennungskraft Messtech | Optischer sensor und verfahren zu dessen herstellung |
EP0381026A3 (de) | 1989-02-03 | 1991-05-02 | F. Hoffmann-La Roche Ag | Optischer Sauerstoffsensor |
EP0429907B1 (de) * | 1989-11-21 | 1994-06-01 | Bayer Ag | Optischer Biosensor |
DE4208645A1 (de) * | 1992-03-18 | 1993-09-23 | Bayer Ag | Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten |
US5585235A (en) | 1993-04-13 | 1996-12-17 | Diagnescent Technologies, Inc. | Fluorescent assay and method that corrects for spectral interference |
JP3359409B2 (ja) * | 1994-01-12 | 2002-12-24 | 株式会社ナガオカ | 汚泥処理用加圧式脱水装置および汚泥処理方法 |
US5945526A (en) * | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
FI102922B (fi) | 1996-06-28 | 1999-03-15 | Valtion Teknillinen | Fluoresenssiin perustuva immunomääritysmenetelmä |
AT405103B (de) | 1996-10-16 | 1999-05-25 | Avl Verbrennungskraft Messtech | Sensorschicht zur quantitativen bestimmung zumindest einer chemischen komponente einer gasförmigen oder flüssigen probe |
AT405462B (de) * | 1997-05-30 | 1999-08-25 | Avl List Gmbh | Verfahren zur bestimmung eines alkaliions |
US6348322B1 (en) * | 1997-10-17 | 2002-02-19 | Duke University | Method of screening for specific binding interactions |
GB2341189B (en) * | 1998-08-31 | 2001-06-13 | Amersham Pharm Biotech Inc | Energy transfer dyes |
AT409307B (de) | 1999-01-12 | 2002-07-25 | Hoffmann La Roche | Optisch-chemischer sensor |
GB9901072D0 (en) * | 1999-01-19 | 1999-03-10 | Imp Cancer Res Tech | Methods for detecting changes to a macromolecular component of a cell |
WO2002039083A2 (en) | 2000-11-08 | 2002-05-16 | Science & Technology Corporation @ Unm | Fluorescence and fret based assays for biomolecules on beads |
AT410601B (de) | 2000-12-29 | 2003-06-25 | Hoffmann La Roche | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
-
2000
- 2000-12-29 AT AT0216100A patent/AT410601B/de not_active IP Right Cessation
-
2001
- 2001-12-21 EP EP01984880A patent/EP1346220B1/de not_active Expired - Lifetime
- 2001-12-21 US US10/451,958 patent/US7456023B2/en not_active Expired - Lifetime
- 2001-12-21 EP EP01986432A patent/EP1346223B1/de not_active Expired - Lifetime
- 2001-12-21 DE DE50115064T patent/DE50115064D1/de not_active Expired - Lifetime
- 2001-12-21 AT AT01984880T patent/ATE440283T1/de not_active IP Right Cessation
- 2001-12-21 WO PCT/EP2001/015186 patent/WO2002054076A2/de active Application Filing
- 2001-12-21 JP JP2002554697A patent/JP3740466B2/ja not_active Expired - Fee Related
- 2001-12-21 DE DE50111978T patent/DE50111978D1/de not_active Expired - Lifetime
- 2001-12-21 US US10/465,935 patent/US7067320B2/en not_active Expired - Lifetime
- 2001-12-21 AT AT01986432T patent/ATE352786T1/de not_active IP Right Cessation
- 2001-12-21 JP JP2002554723A patent/JP3782780B2/ja not_active Expired - Lifetime
- 2001-12-21 WO PCT/EP2001/015185 patent/WO2002054045A2/de active IP Right Grant
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